DIMERIZABLE CATIONIC DETERGENTS CONDENSE PLASMID DNA INTO 30 NM PARTICLES AND TRANSFECT CELLS IN VITRO

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外文摘要：In the present investigation， we report the biophysical and biological properties of the ornithinyl-cysteinyl tetradecylamide (C_(14)COrn)。 This new dimerizable detergent condenses plasmid DNA into monomolecular particles of 30 nm。 This complexes are mobile in agarose gel and exhibit a typical lipid/DNA supramolecular structure。 When the complexes are large and cationic they show a transfection efficiency comparable to that obtained with the most potent vectors。

外文关键词：

cationic lipidsdetergentgene therapytransfection

作者：

E. Dauty、J. S. Remy、T. Blessing、J. P. Behr

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作者单位：

Laboratoire de Chimie Genetique associe CNRS/Universite Louis Pasteur, Faculte de Pharmacie de Strasbourg, 67401 Illkirch, France

会议名称：

International symposium on controlled release of bioactive materials;Consumer & diversified products conference

会议地点：

San Diego, CA(US);San Diego, CA(US)

会议母体文献：

28th International Symposium on Controlled Release of Bioactive Materials and Fourth Consumer & Diversified Products Conference Vol.2, Jun 23-27, 2001, Sand Diego, California, U.S.A.

页码：

p.1135-1136

出版时间：

2001