ENHANCED INTESTINAL ABSORPTION OF LHRH AND LEUPROLIDE IN THE RAT FROM LIPID POLYMER MICELLES

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外文摘要：The intestinal absorption of LHRH and leuprolide was determined in rats from various lipid polymer micelle formulations。 Upon intraduodenal administration of LHRH or leuprolide consistent and reproducible pharmacokinetics was obtained with a mean relative bioavailability of about 10 and 28%， respectively。 There was a dose dependence of LHRH and leuprolide absorption。

外文关键词：

LHRHpolymeric micellesdrug absorption

作者：

P. P. Constantinides、L. Liang、E.-H. Jang、D. Fast、L. He、L. Li、K. Bosnian、K. Opeifa

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作者单位：

DOR BioPharma Inc, Lake Forest, IL 60045

会议名称：

Proceedings of the 29th Annual Meeting of the Controlled Release Society

会议母体文献：

29th Annual Meeting of the Controlled Release Society Jul 22-24, 2002 null

页码：

p.976-977

出版时间：

2002