Injury thresholds for topical-cream-coated skin of hairless guinea pigs (cavia porcellus) in the near infrared region

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外文摘要：The reflectance and absorption of the skin plays a vital role in determining how much radiation will be absorbed by human tissue。 Any substance covering the skin would change the way radiation is reflected and absorbed and thus the extent of thermal injury。 Hairless guinea pigs (cavia porcellus) in vivo were used to evaluate how the minimum visible lesion threshold for single-pulse laser exposure is changed with a topical agent applied to the skin。 The ED_(50) for visible lesions due to an Er: glass laser at 1540-nm with a pulse width of 50-ns was determined， and the results were compared with model predictions using a skin thermal model。 The ED_(50) is compared with the damage threshold of skin coated with a highly absorbing topical cream at 1540 nm to determine its effect on damage pathology and threshold。 The ED_(50) for the guinea pig was then compared to similar studies using Yucatan minipigs and Yorkshire pigs at 1540-nm and nanosecond pulse duration。 The damage threshold at 24-hours of a Yorkshire pig for a 2。5-3。5-mm diameter beam for 100 ns was 3。2 Jcm~(-2); very similar to our ED_(50) of 3。00 Jcm~(-2) for the hairless guinea pigs。

外文关键词：

laserlaser safetyskintakata skin modelMVLED_(50)guinea pigslaser induced breakdown

作者：

Ginger M. Pocock、Justin J. Zohner、David J. Stolarski、Kelvin C. Buchanan、Nichole M. Jindra、Manuel A. Figueroa、Lucas J. Chavey、Michelle L. Imholte、Robert J. Thomas、Benjamin A. Rockwell

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作者单位：

U.S. Air Force Research Laboratory, Optical Radiation Branch, Brooks City-Base, TX 78235-5128

会议名称：

Conference on Optical Interactions with Tissue and Cells XVII; 20060123-25; San Jose,CA(US)

会议地点：

San Jose,CA(US)

会议母体文献：

Optical Interactions with Tissue and Cells XVII; Progress in Biomedical Optics and Imaging; vol.7, no.7

页码：

P.60840I.1-60840I.11

出版时间：

2006