Modulation of coherent oscillations in inhibitory networks by anesthetics

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外文摘要：Experiments in cultured hippocampal cells show that the anesthetic propofol enhances inhibition through its action on the GABA_A channel。 Inhibitory networks have been shown to synchronize in the 20-80 Hz range， and this activity correlates with some cognitive functions。 We examined the effect of propofol on synchronous activity in model networks connected by GABAergic synapses。 A kinetic model of the GABA_A channel including the effect of propofol was used。 Propofol modified the range of inputs for which synchronous activity is observed， and we show here that this effect is independent of network size。 These results show that propofol can disrupt synchronized gamma oscillations in neuronal networks。

外文关键词：

synchronyneuronal networkcoherence measureGABA_A synapse

作者：

Pamela M. Baker、Frances K. Skinner

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作者单位：

Toronto Western Research Institute, University Health Network, Department of Physiology, University of Toronto, Toronto, Ont., Canada

会议名称：

Computational Neuroscience Trends in Research 2002

会议地点：

Monterey, CA(US);Monterey, CA(US)

会议母体文献：

Computational Neuroscience Meeting (CNS'01) Jul, 2001 Monterey, California

页码：

p.293-299

出版时间：

2001