Threshold Damage of In Vivo Porcine Skin at 2000 nm Laser Irradiation

扫码查看

原文链接

NETL

外文摘要：A series of experiments were conducted in vivo on female Yucatan mini-pigs to determine the ED_(50) damage thresholds for 2000 nm continuous wave laser irradiation。 These results provide new information for refinement of Maximum Permissible Exposure (MPE)。 The study employed Gaussian laser beam exposures with spot diameters (1/e~2) of 4。83 mm， 9。65 mm and 14。65 mm and exposure durations of 0。25 s， 0。5 s， 1。0 s and 2。5 seconds as a function of laser power。 The effect of each irradiation was evaluated within one minute after irradiation and the final determination was made at 48 hours post exposure。 Probit analysis was conducted to estimate the dose for 50% probability of laser-induced damage (ED_(50)) defined as persistent redness at the site of irradiation for the mini-pig skin after 48 hours。 Histopathologic procedures were used to determine the mechanisms of the laser effects in the skin and map the extent and severity of the lesions。 The thresholds study shows that consideration for lowering the current Maximum Permissible Exposure (MPE) limits should be explored as the laser beam diameter becomes larger than 3。5 mm。 Based on the limited experimental data， the duration and size dependences of the ED_(50) damage thresholds could be described by an empirical equation: Irradiance at the threshold[J/cm~2] = (5。669 - 1。81 x spot diameter [cm]) x exposure duration[s] ~(-0。794)。

外文关键词：

gaussian laser irradiationlaser injurylaser safetymaximum permissible exposure (MPE)skin damagevisible lesionyucatan mini-pig

作者：

Bo Chen、Daniel C. O'Dell、Sharon L. Thomsen、Benjamin A. Rockwell、Ashley J. Welch

展开 >

作者单位：

Biomedical Engineering Laser Laboratory, University of Texas at Austin, Austin, Texas 78712

会议名称：

Conference on Optical Interactions with Tissue and Cells XVII; 20060123-25; San Jose,CA(US)

会议地点：

San Jose,CA(US)

会议母体文献：

Optical Interactions with Tissue and Cells XVII; Progress in Biomedical Optics and Imaging; vol.7, no.7

页码：

P.60840C.1-60840C.9

出版时间：

2006