首页|A rejuvenation method of inducing the proliferation and differentiation of glomeruluar podocyte
A rejuvenation method of inducing the proliferation and differentiation of glomeruluar podocyte
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Glomerular pococyte is a giant cell containing many foot processes located at the outside of glomerular basement membrane。 It plays important roles in regulating blood filtration and is known as a terminal differentiated cell。 No proliferation capability can be found in podocyte。 Damaged podocyte shows morphological defect of slit diaphragm which results in protein urine。 In this study, we developed a method enabling podocyte proliferation。 We also unveiled possible excelluar matrices involving podocyte proliferation。 Using our developed co-culture system, the proliferating podocyte can recover differentiation capability and maintain slit diaphragm。