Uniform Mesoporous Dye-Doped Silica Nanoparticles as a Multifunctional Drug Carrier for in vivo early tumor diagnosis

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原文链接

NETL
Spie-Int Soc Optical Engineering

外文摘要：In this report， we synthesized multifunctional dye-doped mesoporous silica nanoparticles(MSNs) by encapsulating near-infrared dyes into the nanoparticles。 In order to enhance the targeting property， the surface was modified with amino group for further conjugation of targeted ligands。 In addition， we explored the influence of the synthetic temperature on the particle morphology。 The optical properties， morphology and structure of the as-prepared dye-doped silica nanoparticles were characterized。 Results indicated the dye-doped silica nanoparticles can be used as a good probe for early tumor diagnosis and have the potential to serve as a targeted carrier for antitumor drugs。

外文关键词：

mesoporous silica nanoparticlsnear-infrared dyessurface modificationdrug carriers

作者：

Jie Cao、Junfei Xia、Dawei Deng、Yueqing Gu

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作者单位：

Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China

会议名称：

Conference on optics in health care and biomedical optics IV

会议地点：

Beijing(CN)

会议母体文献：

Optics in health care and biomedical optics IV

页码：

p.78451R.1-78451R.7

出版时间：

2010

DOI：

10.1117/12.866940