Early Metabolic and Structural Changes in the Rat Brain Following Trauma in vivo Using MRI

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外文摘要：Traumatic brain injury (TBI) is characterized by acute physiological changes that may play a significant role in the final outcome for the patient The understanding of tissue alterations at an early stage following TBI is critical for injury management and prevention of more severe secondary damage。 In this study we investigated the early post-traumatic neuro-metabolic changes， and changes in tissue water diffusion using proton magnetic resonance spectroscopy ('H MRS) and diffusion tensor imaging (DTI) following mild to moderate controlled cortical impact injury on six adult male Sprague-Dawley rats on a 7。0 Tesla animal MRI system。 Significant reduction in N-acetylaspartate， glutamate and choline was observed as early as 3 hours following injury。 Lactate continued to increase in the ipsi-lateral hippocampus even at 5 hours indicating increased demands for energy closer to the injury site。 Such changes were not observed on the contralateral side at 5 hours。 Decreased apparent diffusion coefficient and increased fractional anisotropy was observed among regions in close proximity to impacted regions (ipsilateral hippocampus and bi-lateral thalamus) immediately following TBI， with the ipsilateral hippocampus most affected， followed by ipsilateral thalamus and contralateral thalamus。 Remote regions such as the ipsilateral olfactory area were affected to a lesser degree。 At the 4 hour time point a large inter-individual variation was observed with an overall trend towards recovery in the ipsilateral hippocampus while the thalamus continued to experience significant changes。 Combined information from MRS and DTI suggests a distance effect from the site of injury and the existence of a therapeutic window of about 2-4 hours to limit the cascade of events that may lead to secondary injury。

外文关键词：

magnetic resonance imagingin vivoproton magnetic resonance spectroscopydiffusion tensor imagingtraumatic brain injury

作者：

S. Xu、J. Zhuo、J. Racz、S. Roys、D. Shi、G. Fiskum、R. Gullapalli

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作者单位：

Department of Diagnostic Radiology and Nuclear Medicine,Maryland University of Maryland School of Medicine, Baltimore, MD 21201, USA,Core for Translational Research in Imaging @ Maryland University of Maryland School of Medicine, Baltimore, MD 21201, USA

Department of Anesthesiology and the Center for Shock Trauma and Anesthesiology Research (STAR),Maryland University of Maryland School of Medicine, Baltimore, MD 21201, USA

Department of Anesthesiology and the Center for Shock Trauma and Anesthesiology Research (STAR),Maryland University of Maryland School of Medicine, Baltimore, MD 21201, USA,Core for Translational Research in Imaging @ Maryland University of Maryland School of Medicine, Baltimore, MD 21201, USA

会议名称：

Southern biomedical engineering conference;SBEC 2010

会议地点：

College Park, MD(US);College Park, MD(US)

会议母体文献：

26th Southern biomedical engineering conference

页码：

p.5-8

出版时间：

2010