Freeze-drying and characterization of Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (NLC)

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NETL
Trans Tech Publications Ltd

外文摘要：Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique。 Trehalose， glucose， mannitol， α-lactin， D-sorbitol， D-maltose monohydrate and sucrose were chosen as the cryoprotectants。 Also， the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively。 Glucose and a-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process。 The most suitable concentrations were proved to be 5 wt% and 5 wt%， respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying。 In conclusion， the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry。

外文关键词：

nanostructured lipid carriersvitamin a palmitatecryoprotectantslyophilisationhigh pressure homogenization

作者：

Qiang Xia、Rong Kong

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作者单位：

School of Biological Science&Medical Engineering, Southeast University, Nanjing 210096, China,State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China,Suzhou Key Laboratory of Biomedical Materials and Technology, Southeast University,Suzhou 215123, China,Suzhou Nanohealth Biotech Co., Ltd., Suzhou 215123, China

会议名称：

International conference on frontier of nanoscience and technology;ICFNST 2011

会议地点：

Kunming(CN);Kunming(CN)

会议母体文献：

Frontier of nanoscience and technology

页码：

p.365-369

出版时间：

2011

DOI：

10.4028/www.scientific.net/MSF.694.365