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NcRNA-Class Web Tool: Non-coding RNA Feature Extraction and Pre-miRNA Classification Web Tool

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Until recently, it was commonly accepted that most genetic information is transacted by proteins。 Recent evidence suggests that the majority of the genomes of mammals and other complex organisms are in fact transcribed into non-coding RNAs (ncRNAs), many of which are alternatively spliced and/or processed into smaller products。 Non coding RNA genes analysis requires the calculation of several sequential, thermodynamical and structural features。 Many independent tools have already been developed for the efficient calculation of such features but to the best of our knowledge there does not exist any integrative approach for this task。 The most significant amount of existing work is related to the miRNA class of non-coding RNAs。 MicroRNAs (miRNAs) are small non-coding RNAs that play a significant role in gene regulation and their prediction is a challenging bioinformatics problem。 Non-coding RNA feature extraction and pre-miRNA classification Web Tool (ncRNA-class Web Tool) is a publicly available web tool which provides a user friendly and efficient environment for the effective calculation of a set of 58 sequential, thermodynamical and structural features of non-coding RNAs, plus a tool for the accurate prediction of miRNAs。

ncRNAsmiRNAfeature calculationmiRNA predictionweb tool

Dimitrios Kleftogiannis、Konstantinos Theofilatos、Stergios Papadimitriou、Athanasios Tsakalidis、Spiros Likothanassis、Seferina Mavroudi

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Math. & Computer Sciences & Engineering King Abdullah Univ. of Science and Technology, Saudi Arabia

Department of Computer Engineering and Informatics, University of Patras, Greece

Department of Information Management, Technological Institute of Kavala, Greece

Department of Computer Engineering and Informatics, University of Patras, Greece,Department of Social Work, School of Sciences of Health and Care, Technological Educational Institute of Patras

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AIAI 2012;IFIP WG 12.5 International Conference on artificial intelligence applications and innovations;Artificial intelligence applications in biomedicine workshop;International workshop on computational intelligence in software engineering;AI in educatio

Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR);Halkidiki(GR)

Artificial intelligence applications and innovations.;part 2.

p.632-641

2012