Development of Peptide Fusion Inhibitors Targeting HIV-1 gp41

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外文摘要：HIV-1 membrane fusion plays an important role in the process that HIV-1 entrys cells。As a new treatment options targeting HIV-1 entry process，fusion inhibitors have been proposed。Peptide T20 which derived from viral envelope glycoprotein gp41，is the first and only HIV-1 fusion inhibitor approved by the FDA。Currently，a large number of prospective fusion peptides have emerged。This paper introduced the possible mechanism of fusion inhibitor，reported the current developments and innovative designs of HIV-1 membrane fusion inhibitors。

外文关键词：

HIVgp41membrane fusionfusion inhibitormechanism

作者：

Xue Ting Ma、Xiao Hui Sun、Jian Jun Tan、Cun Xin Wang

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作者单位：

College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China

会议名称：

World congress on medical physics and biomedical engineering

会议地点：

Beijing(CN)

会议母体文献：

World congress on medical physics and biomedical engineering

页码：

2221–2223

出版时间：

2012