Bioimpedance spectroscopy method for investigating changes to intracranial dose during transcranial direct current stimulation

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外文摘要：Tissue resistance changes upon application of DC current。 We posit that in a similar fashion， that scalp and skull resistances during trancranial direct current stimulation (tDCS) are variable， resulting in changes to intracranial dose。 Transcranial magnetic stimulation (TMS)， electoencephelogram (EEG)， functional magnetic resonance imaging (fMRI)， proton magnetic resonance spectroscopy (H MRS) and functional near infrared spectroscopy (fNIRS) are technologies used to measure individual neural response to tDCS。 These technologies are complex and may not be directly correlated to intracranial dose。 We therefore present a bioimpedance spectroscopy method of measuring changes to the intracranial dose in vivo。 Scalp resistance changes are measured during tDCS。 Current flow through the scalp is calculated as the ratio of voltage measured on the scalp and scalp resistance。 Variation of intracranial current is indirectly calculated from changes in the current shunted through the scalp。 We thus demonstrate a novel methodology of on-line monitoring of scalp resistance and current as an objective feedback of estimated individual tDCS dose。

外文关键词：

bioelectric potentialsbiomedical MRIbraindosimetryelectric resistanceelectroencephalographyinfrared spectroscopyneurophysiologyradiation therapytranscranial magnetic stimulation<sup>1</sup>H MRSDC currentEEGTMSbioimpedance spectroscopy methodcurrent flowelectoencephelogramfMRIfNIRSfunctional magnetic resonance imagingfunctional near infrared spectroscopyintracranial currentintracranial dose in vivoneural responseonline monitoringproton magnetic resonance spectroscopyscalp resistancesskull resistancestDCS dosetissue resistancetrancranial direct current stimulationtranscranial direct current stimulationtranscranial magnetic stimulationCurrent measurementElectrical resistance measurementElectrodesImmune systemImpedanceImpedance measurementScalp

作者：

Caytak, Herschel、Nejadgholi, Isar、Batkin, Izmail、Bolic, Miodrag

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作者单位：

Sch. of Electr. Eng. & Comput. Sci., Univ. of Ottawa, Ottawa, ON, Canada

会议名称：

Annual International Conference of the IEEE Engineering in Medicine and Biology Society

会议地点：

Milan(IT)

会议母体文献：

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

页码：

3448-3451

出版时间：

2015

DOI：

10.1109/EMBC.2015.7319134