The study is based on the older Finnish Twin Cohort of same-sex twin pairs born before 1958。 In 1988 a questionnaire was sent to 1005 twin pairs discordant for hypertension。 1495 individuals (688 men， 807 women) aged 31-88 years replied。 For 573 twin pairs (131 MZ and 442 DZ) both twins had answered the question on noise sensitivity。 We used the classic twin study design， which compares phenotypic resemblance of monozygotic (MZ) and dizygotic (DZ ) twins reared together。 Univariate model， which offers information on the effect of genetic and environmental factors on one phenotype， was used。 If noise sensitivity has a genetic component， monozygotic twins would be expected to demonstrate greater similarity with regards noise sensitivity than dizygotic twins。 Monozygotic twin pairs were more similar with regards noise sensitivity than dizygotic twin pairs。 The intraclass correlations for noise sensitivity in MZ pairs was 0。36 (95% CI 0。16-0。52) and in DZ pairs 0。19 (95% CI 0。07-0。31)。 Excluding those pairs in which one or both were hearing impaired did not significantly change the correlations between twins in MZ and DZ pairs。 Correlations for male and female pairs did not differ significantly statistically。 Quantitative genetic modeling indicated significant familiality meaning that noise sensitivity aggregates in families。 The best-fitting model was the AE model， which indicates that genetic factors and unique experiences account for the variability in noise sensitivity in the population。 The AE model provided an estimate of heritability of 36 %。 The central results presented here have been published in Twin Research and Human Genetics。
Noise sensitivitygenetic componentheritability
Marja Heinonen-Guzejev、Heikki S. Vuorinen、Helena Mussalo-Rauhamaa、Kauko Heikkilae、Markku Koskenvuo、Jaakko Kaprio
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Hjelt Institute, Department of Public Health, PO Box 41, FI-00014 University of Helsinki, Finland
Hjelt Institute, Department of Public Health, PO Box 41, FI-00014 University of Helsinki, Finland,Department of Mental Health and Substance Abuse Services, National Institute of Health and Welfare, PO Box 30, FI-00271 Helsinki, Finland,Institute for Molecular Medicine Finland, FIMM, PO Box 20, FI-00014 University of Helsinki, Finland
International congress on exposition noise control engineering
Osaka(JP)
40th international congress and exposition on noise control engineering 2011
NETL
