Four new steroidal saponins (1-4), together with two known steroidal glycosides (5 and 6）were obtained from the roots and rhizomes of Smilacina japonica, their structures were determined to be(25S）-5α-spirostan-9(11)-en-3β,17a-diol(1),(25S)-5α-spirostan-9(11)-en-3β, 12}-diol (2),(25S)-5α-spirostan-9(11)-en-3β,17α-diol-3-O-β-D-glucopyranoside(3),(25S)-5α-spirostan-9(11)-en-3β,17α-diol-3-O-β-D-glucopyranosyl-(1-2)-[β-D-glucopyranosyl-(1-3)]-β-D-galactopyranoside (4),japonicoside B(5)and japonicoside C (6), by physicochemical properties and spectroscopic methods.In addition, their cytotoxicactivity against human SMMC-7712, Bet-7402, A549, H460 and K562 tumor cells was evaluated by MTTmethod and all the compounds exhibited cytotoxicity with the cell lines.
CUI YU-wen、崔誉文、TANG Hai-feng、汤海峰、SONG Xiao-mei、宋小妹
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Institute of Materia Medica,School of Pharmacy,Air Force Medical University,Xi'an 710032
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