首页|Effectiveness of Antithymocyte globulin therapy with or without cyclosporine and human hematopoietic growth factors in children with acquired aplastic anemia: A case report and literature review.
Effectiveness of Antithymocyte globulin therapy with or without cyclosporine and human hematopoietic growth factors in children with acquired aplastic anemia: A case report and literature review.
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NETL
Hematopoietic stem cell transplantation cures aplastic anemia and has been made the treatment of choice for young patients who have suitable stem cell donors,whereas immunosuppressive therapy is the first- line treatment for most patients without suitable donors [1]. Antithymocyte globulin has been the standard immunosuppressive regimen for aplastic anemia for many years and has demonstrated a 40-50% response rate when used alone [1,2] and a 60-70% response rate when combined with cyclosporine [3] with 35% relapse rate and the development of clonal diseases a significant problem to responders [4,5]. This paper reports a case of a child with acquired aplastic anemia managed with pig Antithymocyte globulin (p-ATG) and a review of literature on the effectiveness in clinical use of Antithymocyte globulin either as a monotherapy or in combination therapy with cyclosporine including or excluding human hematopoietic growth factors for the management of acquired aplastic anemia in children.
NETL
