Breeze, Charles E.Beck, StephanBerndt, Sonja, IFranceschini, Nora...
3页
查看更多>>摘要：Recent work has highlighted a lack of diversity in genomic studies。 However， less attention has been given to epigenomics。 Here， we show that epigenomic studies are lacking in diversity and propose several solutions to address this problem。
Martin, Alicia R.Stroud, Rocky E., IIAbebe, TamratAkena, Dickens...
6页
查看更多>>摘要：Calls for diversity in genomics have motivated new global research collaborations across institutions with highly imbalanced resources。 We describe practical lessons we have learned so far from designing multidisciplinary international research and capacity-building programs that prioritize equity in two intertwined programs - the NeuroGAP-Psychosis research study and GINGER training program - spanning institutions in Ethiopia， Kenya， South Africa， Uganda and the United States。
查看更多>>摘要：A new study employs CRISPR-Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals， highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation。
查看更多>>摘要：A new study highlights a strategy to link SNPs implicated in human complex traits and diseases with probable causal genes。 This method prioritizes genes for functional characterization and helps address questions about the architecture of human phenotypes。
查看更多>>摘要：A large-scale single-nucleus chromatin accessibility profiling study in coronary artery samples from patients with coronary artery disease generated a landscape of the regulatory activity during the disease。 These data highlight cell type-specific gene programs that can improve the interpretation of human genome-wide association studies findings for cardiovascular diseases。
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