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Vision Research
Pergamon
Vision Research

Pergamon

0042-6989

Vision Research/Journal Vision ResearchSCIAHCIISTP
正式出版
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    Blast mild traumatic brain injury is associated with increased myopia and chronic convergence insufficiency

    Fortenbaugh, Francesca C.Gustafson, Jennifer A.Fonda, Jennifer R.Fortier, Catherine B....
    12页
    查看更多>>摘要:While chronic visual symptom complaints are common among Veterans with a history of mild traumatic brain injury (mTBI), research is still ongoing to characterize the pattern of visual deficits that is most strongly associated with mTBI and specifically, the impact of blast-related mTBI on visual functioning. One area that has not been well explored is the potential impact of blast mTBI on refractive error. While myopic shifts have been documented following head injuries in civilian populations, posttraumatic myopic shifts have not been explored in participants with military mTBI. This study investigated the impact of blast mTBIs on a range of visual function measures including distance acuity and refractive error, in a well-characterized cohort of thirty-one Post-9/11 veterans for whom detailed clinical interviews regarding military and TBI history were available. Seventeen participants had a history of blast-related mTBI (blast mTBI + group) while 14 did not (blast mTBI- group). Results show an increased frequency of convergence insufficiency and myopia in the blast mTBI + group relative to the blast mTBI- group. Linear regression analyses further show that deficits in distance acuity and refractive error are associated with the number of blast mTBIs during military service but not the number of non-blast mTBIs or the number of lifetime non-blast TBIs and cannot be accounted for by PTSD. These results are consistent with long-lasting damage following blast mTBI to subcortical visual structures that support both vergence movements and the accommodative functions needed to see clearly objects at varying distances.

    Blast mild traumatic brain injury is associated with increased myopia and chronic convergence insufficiency

    Fortenbaugh, Francesca C.Gustafson, Jennifer A.Fonda, Jennifer R.Fortier, Catherine B....
    12页
    查看更多>>摘要:While chronic visual symptom complaints are common among Veterans with a history of mild traumatic brain injury (mTBI), research is still ongoing to characterize the pattern of visual deficits that is most strongly associated with mTBI and specifically, the impact of blast-related mTBI on visual functioning. One area that has not been well explored is the potential impact of blast mTBI on refractive error. While myopic shifts have been documented following head injuries in civilian populations, posttraumatic myopic shifts have not been explored in participants with military mTBI. This study investigated the impact of blast mTBIs on a range of visual function measures including distance acuity and refractive error, in a well-characterized cohort of thirty-one Post-9/11 veterans for whom detailed clinical interviews regarding military and TBI history were available. Seventeen participants had a history of blast-related mTBI (blast mTBI + group) while 14 did not (blast mTBI- group). Results show an increased frequency of convergence insufficiency and myopia in the blast mTBI + group relative to the blast mTBI- group. Linear regression analyses further show that deficits in distance acuity and refractive error are associated with the number of blast mTBIs during military service but not the number of non-blast mTBIs or the number of lifetime non-blast TBIs and cannot be accounted for by PTSD. These results are consistent with long-lasting damage following blast mTBI to subcortical visual structures that support both vergence movements and the accommodative functions needed to see clearly objects at varying distances.

    Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells

    Wu, Samuel M.Zhang, Ai-Jun
    10页
    查看更多>>摘要:Cone photoreceptors are the first neurons along the visual pathway that exhibit center-surround antagonistic receptive fields, the basic building blocks for spatial information processing in the visual system. The surround responses in cones are mediated by the horizontal cells (HCs) via multiple feedback synaptic mechanisms. It has been controversial on which mechanisms are responsible for the surround-elicited depolarizing responses in cones (Delta V-Cone(s)), and whether the surround responses of various types of cones are mediated by the same HC feedback mechanisms. In this report, we studied Delta V-Cone(s)) of four types of cones in the salamander retina, and found that they are mediated by feedback synapses from A-type, B-type or A- and B-type HCs. Delta V-Cone(s) are observable in the presence of concomitant center light spots, and surround + center light stimuli of various intensity, size and wavelength differentially activate the feedback synapses from A- and B-type HCs to cones. We found that Delta V-Cone(s) of the L-cones are mediated by both A- and B-type HCs, those of the P- and S-cones by B-type HCs, and those of the A-cones by the A-type HCs. Moreover, our results suggest that B-type HCs mediate Delta V-Cone(s) through both GABAergic and GluT-ClC feedback synaptic mechanisms, and A-type HCs mediate Delta V-Cone(s) via the GluT-ClC feedback mechanism. Feedback synaptic mechanisms that increase calcium influx in cone synaptic terminals play important roles in mediating the antagonistic surround responses in the postsynaptic bipolar cells, but they may not generate enough current to depolarize the cones and significantly contribute to Delta V-Cone(s).

    Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells

    Zhang, Ai-JunWu, Samuel M.
    10页
    查看更多>>摘要:Cone photoreceptors are the first neurons along the visual pathway that exhibit center-surround antagonistic receptive fields, the basic building blocks for spatial information processing in the visual system. The surround responses in cones are mediated by the horizontal cells (HCs) via multiple feedback synaptic mechanisms. It has been controversial on which mechanisms are responsible for the surround-elicited depolarizing responses in cones (Delta V-Cone(s)), and whether the surround responses of various types of cones are mediated by the same HC feedback mechanisms. In this report, we studied Delta V-Cone(s)) of four types of cones in the salamander retina, and found that they are mediated by feedback synapses from A-type, B-type or A- and B-type HCs. Delta V-Cone(s) are observable in the presence of concomitant center light spots, and surround + center light stimuli of various intensity, size and wavelength differentially activate the feedback synapses from A- and B-type HCs to cones. We found that Delta V-Cone(s) of the L-cones are mediated by both A- and B-type HCs, those of the P- and S-cones by B-type HCs, and those of the A-cones by the A-type HCs. Moreover, our results suggest that B-type HCs mediate Delta V-Cone(s) through both GABAergic and GluT-ClC feedback synaptic mechanisms, and A-type HCs mediate Delta V-Cone(s) via the GluT-ClC feedback mechanism. Feedback synaptic mechanisms that increase calcium influx in cone synaptic terminals play important roles in mediating the antagonistic surround responses in the postsynaptic bipolar cells, but they may not generate enough current to depolarize the cones and significantly contribute to Delta V-Cone(s).

    Early recurrence enables figure border ownership

    Mehrani, PariaTsotsos, John K.
    11页
    查看更多>>摘要:Rubin's face-vase illusion demonstrates how one can switch back and forth between two different interpretations depending on how the figure outlines are assigned. In the primate visual system, assigning ownership along figure borders is encoded by neurons called the border ownership (BO) cells. Studies show that the responses of these neurons not only depend on the local features within their receptive fields, but also on contextual information. Despite two decades of studies on BO neurons, the ownership assignment mechanism in the brain is still unknown. Here, we propose a hierarchical recurrent model grounded on the hypothesis that neurons in the dorsal stream provide the context required for ownership assignment. Our proposed model incorporates early recurrence from the dorsal pathway as well as lateral modulations within the ventral stream. While dorsal modulations initiate the response difference to figure on either side of the border, lateral modulations enhance the difference. We found responses of our dorsally-modulated BO cells, similar to their biological counterparts, are invariant to size, position and solid/outlined figures. Moreover, our model BO cells exhibit comparable levels of reliability in the ownership signal to biological BO neurons. We found dorsal modulations result in high levels of accuracy and robustness for BO assignments in complex scenes compared to previous models based on ventral feedback. Finally, our experiments with illusory contours suggest that BO encoding could explain the perception of such contours in higher processing stages in the brain.

    Early recurrence enables figure border ownership

    Mehrani, PariaTsotsos, John K.
    11页
    查看更多>>摘要:Rubin's face-vase illusion demonstrates how one can switch back and forth between two different interpretations depending on how the figure outlines are assigned. In the primate visual system, assigning ownership along figure borders is encoded by neurons called the border ownership (BO) cells. Studies show that the responses of these neurons not only depend on the local features within their receptive fields, but also on contextual information. Despite two decades of studies on BO neurons, the ownership assignment mechanism in the brain is still unknown. Here, we propose a hierarchical recurrent model grounded on the hypothesis that neurons in the dorsal stream provide the context required for ownership assignment. Our proposed model incorporates early recurrence from the dorsal pathway as well as lateral modulations within the ventral stream. While dorsal modulations initiate the response difference to figure on either side of the border, lateral modulations enhance the difference. We found responses of our dorsally-modulated BO cells, similar to their biological counterparts, are invariant to size, position and solid/outlined figures. Moreover, our model BO cells exhibit comparable levels of reliability in the ownership signal to biological BO neurons. We found dorsal modulations result in high levels of accuracy and robustness for BO assignments in complex scenes compared to previous models based on ventral feedback. Finally, our experiments with illusory contours suggest that BO encoding could explain the perception of such contours in higher processing stages in the brain.

    The interaction of global motion and global form processing on the perception of implied motion: An equivalent noise approach

    Joshi, Mahesh R.Simmers, Anita J.Jeon, Seong T.
    7页
    查看更多>>摘要:Global motion and global form are proposed to be processed through functionally differentiated independent channels along dorsal (motion) and ventral (form) pathways. However, more recent studies show significant interactions between these pathways by inducing the perception of motion (implied motion) from presenting the independent frames of static Glass patterns. The mechanisms behind such interaction are not adequately understood with studies showing a larger contribution of either a motion or form processing mechanism. In the current study, we adapted the equivalent noise paradigm to disentangle the effect of internal noise (local processing) and sampling efficiency (global processing) on global motion, global form, and the interaction of both on the perception of implied motion using physically equivalent stimuli. Six visually normal observers discriminated the direction or orientation of random dot kinematograms (RDK), static Glass patterns (Glass), and dynamic Glass patterns (dGlass) whose directions/orientations were determined by the means of normal distributions with a range of direction/orientation variances that served as external noise. Thresholds (tau) showed a consistent pattern across observers and external noise levels, where tau Glass > tau dGlass > tau RDK. Nested model comparisons where the thresholds were related to the external noise, internal noise, and the sampling efficiency revealed that the difference in performance between the tasks was best described by the change in sampling efficiency with invariable internal noise. Our results showed that the higher thresholds for implied motion compared to real motion could be due to inefficient pooling of local dipole orientation cues at global processing stages involving motion mechanisms.

    The interaction of global motion and global form processing on the perception of implied motion: An equivalent noise approach

    Joshi, Mahesh R.Simmers, Anita J.Jeon, Seong T.
    7页
    查看更多>>摘要:Global motion and global form are proposed to be processed through functionally differentiated independent channels along dorsal (motion) and ventral (form) pathways. However, more recent studies show significant interactions between these pathways by inducing the perception of motion (implied motion) from presenting the independent frames of static Glass patterns. The mechanisms behind such interaction are not adequately understood with studies showing a larger contribution of either a motion or form processing mechanism. In the current study, we adapted the equivalent noise paradigm to disentangle the effect of internal noise (local processing) and sampling efficiency (global processing) on global motion, global form, and the interaction of both on the perception of implied motion using physically equivalent stimuli. Six visually normal observers discriminated the direction or orientation of random dot kinematograms (RDK), static Glass patterns (Glass), and dynamic Glass patterns (dGlass) whose directions/orientations were determined by the means of normal distributions with a range of direction/orientation variances that served as external noise. Thresholds (tau) showed a consistent pattern across observers and external noise levels, where tau Glass > tau dGlass > tau RDK. Nested model comparisons where the thresholds were related to the external noise, internal noise, and the sampling efficiency revealed that the difference in performance between the tasks was best described by the change in sampling efficiency with invariable internal noise. Our results showed that the higher thresholds for implied motion compared to real motion could be due to inefficient pooling of local dipole orientation cues at global processing stages involving motion mechanisms.

    The density effect in centroid estimation is blind to contrast polarity

    Rashid, Jordan AliChubb, Charles
    11页
    查看更多>>摘要:Human vision is highly efficient in estimating the centroids of spatially scattered items. However, the processes underlying this remarkable skill remain poorly understood. A salient fact is that in estimating the centroids of dot-clouds, observers underweight densely packed dots relative to isolated dots; thus, when an observer estimates the centroid of a dot cloud, the weight exerted on the subject's response by a given dot tends to be suppressed by other dots near it. The current experiment sought to determine whether dots of contrast polarity equal vs. opposite to a given dot differ in how they alter the weight it exerts. Six observers were tested in a task that used brief (180 ms), Gaussian clouds that mixed 9 white and 9 black dots on a gray background. On each trial, the observer strove to mouse-click the centroid of the stimulus cloud weighting all dots equally. The model used to describe the results allows the weight exerted on the subject's response by a given dot to depend on its peripherality in the stimulus cloud as well as on the density of same- and opposite-polarity dots surrounding it. For four observers, peripheral dots exerted lower influence than central dots on responses; the other two showed little effect of peripherality. For all observers, dots in high-density regions exerted less weight on responses than dots in low-density regions. Concerning the primary research question: dots of opposite vs. the same polarity as a given dot suppressed the weight it exerted with equal effectiveness. This suggests that the site of the interaction producing the density effect is a neural population that registers positive and negative contrast polarities in the same way.

    The density effect in centroid estimation is blind to contrast polarity

    Rashid, Jordan AliChubb, Charles
    11页
    查看更多>>摘要:Human vision is highly efficient in estimating the centroids of spatially scattered items. However, the processes underlying this remarkable skill remain poorly understood. A salient fact is that in estimating the centroids of dot-clouds, observers underweight densely packed dots relative to isolated dots; thus, when an observer estimates the centroid of a dot cloud, the weight exerted on the subject's response by a given dot tends to be suppressed by other dots near it. The current experiment sought to determine whether dots of contrast polarity equal vs. opposite to a given dot differ in how they alter the weight it exerts. Six observers were tested in a task that used brief (180 ms), Gaussian clouds that mixed 9 white and 9 black dots on a gray background. On each trial, the observer strove to mouse-click the centroid of the stimulus cloud weighting all dots equally. The model used to describe the results allows the weight exerted on the subject's response by a given dot to depend on its peripherality in the stimulus cloud as well as on the density of same- and opposite-polarity dots surrounding it. For four observers, peripheral dots exerted lower influence than central dots on responses; the other two showed little effect of peripherality. For all observers, dots in high-density regions exerted less weight on responses than dots in low-density regions. Concerning the primary research question: dots of opposite vs. the same polarity as a given dot suppressed the weight it exerted with equal effectiveness. This suggests that the site of the interaction producing the density effect is a neural population that registers positive and negative contrast polarities in the same way.