查看更多>>摘要：Severe forms of the Coronavirus disease 2019 (COVID-19) are characterized by an enhanced inflammatory syndrome called "cytokine storm" that produces an aberrant release of high amounts of cytokines， chemokines， and other proinflammatory mediators。 The pathogenetic role of the "cytokine storm" has been confirmed by the efficacy of immunosuppressive drugs such as corticosteroids along with antiviral drugs in the treatment of the severe forms of this disease。
查看更多>>摘要：The TransEuropeFootRace (TEFR) was one of the most extreme multistage competitions worldwide。 The ultramarathon took the runners over a distance of 4487 km， from Bari， Italy， to the North Cape， Norway， in 64 days。 The participating ultra-long-distance runners had to complete almost two marathons per day (similar to 70 km)。 The race was accompanied by a research team analysing adaptations of different organ systems of the human body that were exposed to a chronic lack of regeneration time。 Here， we analyzed runner's urine using mass spectrometric profiling of thousands of low-molecular weight compounds。 The results indicated that pre-race molecular factors can predict finishers and separate them from nonfinishers already before the race。 These observations were related to the training volume as finishers ran about twice as many kilometers per week before TEFR than nonfinishers， thus apparently achieving a higher performance level and resistance against overuse。 While this hypothesis needs to be validated in future long-distance races， the bioprofiling experiments suggest that the competition readiness of the runners is measurable and might be adjustable。
NSTL
Elsevier