查看更多>>摘要：Implants have captivated dental fraternity with their attractive benefits alongside patient satisfaction. Nonetheless, success rate depends on the durability of implants without persisting symptoms. Many challenges have yet been addressed by the clinicians, be it the patient selection criteria, implant material susceptibility to microbial environment, procedural errors, etc. Evolving techniques focusing on these issues have resolved to a certain extent but research is still progressing towards perfection. ESWT presents itself as a non-invasive treatment modality beneficial both for the patients as well as the clinicians. Focusing on many of its benefits with its antimicrobial function to bone regeneration has attracted us.
查看更多>>摘要：We propose the intravenous administration of autologous adipose-derived stem cells as a new treatment for Alzheimer?s disease. We hypothesize that the stem cells will secrete neprilysin in the brain to break down and remove amyloid deposits in the Alzheimer?s brain. We have shown a case of skin amyloid deposition that disappeared after stem cell administration and confirmed that the stem cells administered had neprilysin activity. In addition to neprilysin secretion, other mechanisms of action of stem cells include nerve regeneration, nerve repair, growth factor secretion, anti-inflammatory effects, and angiogenesis. The harvesting of adipose-derived stem cells is minimally invasive, and intravenous administration can be safely repeated. We hope that the efficacy of this new treatment will be verified and that it will bring a ray of hope to patients suffering from this incurable disease.
查看更多>>摘要：Broca?s area, conventionally located in left (categorical) hemisphere of brain, is responsible for integrating linguistic and non-linguistic processing however, functionality of its right homolog remains partly understood and explored. This perception is based on the fact that in 96% of right-handed individuals, who constitute 91% of human population, the left hemisphere is dominant or categorical hemisphere. Here, we introduce novel scientific-based hypothesis that the right homolog of Broca?s region which we observed hyperactive during attention focused meditation, might further play an important role in patients with attention deficits and language and speech disorders. Meditation includes self-regulation practices that focus on attention and awareness to achieve better control on mental processes. The positron emission tomography of brain in twelve (12) apparently healthy male, right-handed long-term meditators showed that the right Broca?s area was significantly hyperactive (p = 0.002) during Meditation vs. Baseline while there was only a subtle increase in the activity of left Broca?s area. Our results suggest that hitherto partly explored and understood right homolog of the Broca?s area (referred to as right Broca?s area) may have some important role, especially during meditation which needs to be explored further.
dos Santos, Gabriel ArantesViana, Nayara IzabelPimenta, RuanReis, Sabrina T....
5页
查看更多>>摘要：Currently, the biggest challenge for prostate cancer (PCa) is to understand the mechanism by which the disease acquires the castration-resistant phenotype and progresses to a fatal disease. PCa has a high genetic heterogeneity, and cannot be separated into well-defined molecular subtypes. Despite this, there is consensus about the role of the androgen receptor (AR) in all stages of the disease, including the transition to the castration-resistant phenotype. Since AR is a transcription factor, we investigated the possibility of PCa presenting a pattern of global gene expression during disease progression. By analyzing the TCGA and CCLE datasets, we were able to find a pattern of waves of genes being expressed during each stage of disease progression. This phenomenon suggests the existence of a mechanism that globally regulates gene expression, being AR, telomeres, and zinc finger proteins (ZNF), three important players. The AR modulates the telomere biology, and its transcription is regulated by ZNF. Recently, a study suggested that the telomere length might influence the expression of ZNF. Thus, we hypothesized that changes in the triad AR, telomeres, and ZNF control gene expression during the progression of PCa.
查看更多>>摘要：Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients demonstrate characteristic multistage progression and movement disorders, which are analogous to hystero-epilepsy in Jean-Martin Charcot?s Tuesday Lessons. First, based on a review of the Tuesday Lessons recorded by Charcot?s pupils, we hypothesized that there were patients with anti-NMDAR encephalitis among those diagnosed with hystero-epilepsy in the nineteenth century. We found acute-onset multiple neuropsychiatric manifestations resembling anti-NMDAR encephalitis among patients with hystero-epilepsy. Patients with drug withdrawal syndrome, dissociative and conversion disorders and patients under hypnosis from the modern point of view were also identified. These results suggested that hystero-epilepsy in the Tuesday Lessons could encompass dissociative and conversion disorders, hypnosis, drug withdrawal syndrome, and anti-NMDAR encephalitis-like manifestations. Based on Charcot?s observations and current progress in molecular biology, such as the identification of glutamate/NMDAR system dysfunction in drug withdrawal syndrome, we then hypothesized that patients with dissociative and conversion disorders and those under hypnosis could also have hypofunction of the glutamatergic system. The NMDAR hypofunction hypothesis is emerging as a pathogenesis of schizophrenia. NMDAR antagonists are known to evoke symptoms similar to schizophrenia, anti-NMDAR encephalitis and near-death experiences. In current clinical reports, spectrum disorders such as dissociative disorder and conversion disorder have been observed in patients with anti-NMDAR encephalitis. Our hypothesis will offer an expansion of the NMDAR hypofunction hypothesis from psychosis to functional neurological disorders and normal specific situations, such as hypnosis, thanatosis, and near-death experiences.
查看更多>>摘要：The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19mediated cytokine storm is one of the most important contributors to the development of acute and severe illness in patients. At present, there is an urgent need for drugs that can inhibit cytokine storm to treat COVID-19. In the absence of specific drugs and vaccines, it is important to screen existing drugs as potential treatments. This article introduces a potential repositioning of the existing drug etoricoxib, which may inhibit cytokine storm to treat COVID-19 through reducing the activity of Cyclooxygenase-2 in the conversion of arachidonic acid to prostaglandin.
查看更多>>摘要：Evidence has accumulated that the pathology of CoViD-19 is strongly related to the renin-angiotensin system (RAS). The blockage of the angiotensin converting enzyme 2 (ACE2) by the SARS-CoV-2 virus leads to downstream consequences such as increased vascular tone, extensive fibrosis and pronounced immune reactions. Different approaches to tackle the adverse viral effects by compensating the lost ACE2 function have been suggested. Here, we use an unequal-arm lever model to describe a simplified version of the biased regulation exercised by the angiotensin II and angiotensin-(1?7) hormones, which are the substrate and the product of ACE2, respectively. We reason upon the lever dynamics and its disruptions caused by the virus, and propose that a combination of RAS modulators will most efficiently compensate the imbalance due to the excess of angiotensin II and the scarcity of angiotensin-(1?7). Specifically, we focus on the possible benefits of the simultaneous application of two agents, a MAS-receptor agonist and an angiotensin-II-type-2-receptor agonist. We conjecture that this combination has the potential to introduce a beneficial synergistic action that promotes anti-hypoxic, anti-fibrotic and anti-proliferative effects, thereby improving the clinical management of acute and chronic CoViD-19 pathologies.
NSTL
Elsevier