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Elsevier Science
Sleep medicine

Elsevier Science

1389-9457

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    Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice

    Zhang, YajieNiu, YaqiongYang, XinLi, Zhaojie...
    9页
    查看更多>>摘要：Background and objectives: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder, and has been associated with adverse metabolic outcomes. There is increasing evidence indicating the important role of gut microbiota in OSA and its comorbidities, while the perturbation of intestinal microbial community elicited by OSA has yet to be well-characterized. Here, we investigated the effect of chronic intermittent hypoxia (IH), a hallmark feature of OSA, on gut microbiota in mice.Methods: Male C57BL/6 mice were exposed to a pattern of chronic IH or normoxic conditions for 6 weeks. Fecal samples were collected. The composition of microbiota was determined by 16S rRNA gene amplicon sequencing, and PICRUSt2 was performed to predict functional potential of gut microbiome.Results: In IH mice, accompanied with elevated systemic inflammation, gut microbiota were significantly altered, characterized by enriched Bacteroides, Desulfovibrionaceae and decreased Bifidobacterium. Bacterial operational taxonomic units (OTUs) were clustered into co-abundance groups (CAGs) as potential functional unit in response to IH exposure. One CAG including bacteria of Bacteroides acidifaciens and Desulfovibrionaceae was positively correlated with systemic inflammation in mice, while another CAG composed of bacteria in Muribaculaceae was negatively correlated. Prediction of metabolic pathways showed that, changes in microbiota from IH treatment mainly impacted on bile acid and fatty acid metabolism.Conclusion: Our data demonstrated that dysbiosis of gut microbiome was associated with systemic inflammation and metabolism disorder, and emerges as a mediator for IH and its consequences. Targeting microbiota will be a promising approach to curtail metabolic risks of OSA clinically.(c) 2022 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier

    Menstruation-related hypersomnia. Electroencephalographic and actigraphic correlation in an underrecognized neuropsychiatric disorder

    Villar-Martinez, Maria DoloresPerez-Lorensu, Pedro JavierMoremp-Ajona, DavidPueyo-Morlans, Mercedes...
    3页
    查看更多>>摘要：abuse, and subsequently admitted to the Psychiatry ward with a diagnosis of dissociative identity disorder. Symptoms lasted for 4 days, resolved spontaneously and the patient was discharged.& nbsp;In April 2018, she presented identical symptoms for 5-6 days, which also coincided with her menstruation. Additionally, she reported partial amnesia of the previous days and mild holocranial headache. Neurological examination showed bradypsychia and apathy. Blood tests, including endocrine, metabolic and autoimmune analyses, were within normal limits, as well as brain MRI and magnetic resonance angiography (MRA).& nbsp;A third episode occurred during her menstruation in May 2018, however, this was shorter and symptoms were milder.& nbsp;The last episode took place during her menstruation in June 2018. Her relatives described very mild symptoms, mainly apathy, although a clear slowdown of her physical activity was recorded in actigraphy for two days. She has not had another episode to date.
      原文链接:
    • NSTL
    • Elsevier

    Changed serum levels of CD62E(+), angiotensin II and copeptin in patients with chronic insomnia disorder: a link between insomnia and stroke

    Chen, Jun-TaoZhang, PingKong, Xiao-YiGe, Yi-Jun...
    9页
    查看更多>>摘要：Background: Epidemiological and observational clinical studies have found that insomnia is a risk factor for stroke and that, accordingly, insomnia is likely to cause changes of stroke-related biomarkers. There is substantial evidence that stroke is closely related to endothelial dysfunction and hypertension. The aim of this study is to investigate whether there is alteration of endothelial dysfunction (CD62E(+)) and hypertension (angiotensin II and copeptin) biomarkers in patients with chronic insomnia disorder (CID).Methods: The CID patients (N = 54) and the good sleepers (GS, N = 32) were enrolled. Pittsburgh sleep quality index (PSQI), pre-sleep arousal scale (PSAS) and polysomnography were used to assess their sleep and neuropsychological function. Serum levels of CD62E(+), angiotensin II and copeptin were determined using a quantitative sandwich ELISA.& nbsp;Results: The CID group had higher serum levels of CD62E(+), angiotensin II, and copeptin than the GS group. After controlling for sex, age, depression and apnea-hypopnea index, the partial correlation analysis revealed that the levels of CD62E(+) and copeptin correlated positively with the PSAS score and negatively with the objective sleep quality. Angiotensin II levels negatively correlated with objective sleep onset latency. Moreover, there was a positive correlation between CD62E(+ )and angiotensin II. Principal components analysis revealed that CD62E(+) and copeptin had a substantial correlation with parameters of subjective and objective sleep.Conclusion: Patients with CID exhibit endothelial activation, over-activated renin-angiotensin system and increased sympathetic excitability, as indicated by increased serum levels of CD62E(+), angiotensin II and copeptin, with linking to poor sleep quality.(c) 2022 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier

    LMOD3 gene variant in familial periodic hypersomnolence

    Wenz, ElenaTafti, MehdiBassetti, Claudio L. A.
    4页
    查看更多>>摘要：Introduction: Kleine-Levin syndrome (KLS) is a rare and debilitating disorder presenting with periodic hypersomnolence, cognitive, psychiatric and behavioral disturbances. In the absence of biomarkers it can be difficult to diagnose. Rare LMOD3 variants in a family and in seven sporadic cases with KLS have been described. Here we report a patient and her family with an unclassified, familial, periodic central disorder of hypersomnolence (CDH) in whom the presence of a LMOD3 gene variant was assessed.Case description: The female patient presented since early adulthood with recurrent episodes of hypersomnolence. Over more than 20 years of follow-up the diagnoses of idiopathic hypersomnia, KLS and hypersomnia associated with a psychiatric condition were made. The family history is positive for periodic hypersomnolence and psychiatric conditions.The patient, her symptomatic mother and her asymptomatic sister carried a Proline for Histidine substitution at codon 552 of the LMOD3-gene. This variant was previously reported in two sporadic KLS patients and its frequency in the general population is below 0.02%.Discussion: We report the association of periodic hypersomnia with a polymorphism of the LMOD3-gene in a patient with atypical KLS and a positive family history. Further research is needed to assess the pathological and predictive value of LMOD3 variants in KLS.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
      原文链接:
    • NSTL
    • Elsevier

    The validity and reliability of the Japanese version of RU-SATED

    Furihata, RyujiTateyama, YukikoNakagami, YukakoAkahoshi, Toshiki...
    6页
    查看更多>>摘要：Objective: We developed a Japanese version of RU-SATED (RU-SATED-J), a simple self-rated scale for measurement of multidimensional sleep health, and examined its reliability and psychometric validity.Method: The RU-SATED-J was developed by a rigorous reverse translation process. It consists of six questions, each with three Likert-type response options. The total score (range 0-12) was calculated by summing the item scores. Psychometric characteristics were tested in an observational cross-sectional study involving factory workers in Japan (n = 177, mean age 42.8 & PLUSMN; 11.6 years, range 19-65 years). The distribution and reliability of the scale scores were examined in terms of Cronbach's alpha coeffi-cient. The convergent and divergent validity of the scale score were assessed by examining the correlations of various factors with the Insomnia Severity Index (ISI) and the Epworth Sleepiness Scale (ESS).Results: The distribution of scores was left-skewed, with a mean of 8.21 & PLUSMN; 2.72 points, and range of 0-12. The internal reliability of the scale was a = 0.758. The total score showed a significant negative correlation with the ISS (rs =-0.542, P < 0.001) and the ESS (rs =-0.178, P = 0.018). Exploratory factor analysis (EFA) demonstrated a two-factor structure. Confirmatory factor analysis (CFA) showed that the goodness of fit of the higher-order factor model had a Root Mean Square Error of Approximation (RMSEA) of < 0.001 and a Comparative Fit Index (CFI) of 1.00, confirming its factorial validity.Conclusion: The RU-SATED is a promising new instrument for measuring multi-dimensional sleep health perception among Japanese adults. Further general population studies using this Japanese version of the questionnaire should be considered.
      原文链接:
    • NSTL
    • Elsevier

    Effects of renal denervation on sleep apnea and arrhythmia in rats with myocardial infarction

    Lin, Wei-LunLai, Chun-TingYamada, ShinyaLiu, Shin-Huei...
    9页
    查看更多>>摘要：Background: Sympathetic hyperactivity and poor sleep quality have been reported in patients with myocardial infarction (MI). Sleep is an important modulator of cardiovascular function. We aimed to evaluate the effects of renal denervation (RDN) on cardiac autonomic activity and disordered sleep patterns in rats with MI.Methods: Wireless transmission of polysomnographic recordings was performed in sham and left coronary artery (LCA) ligation male rats during normal daytime sleep before and after RDN. Spectral analyses of electroencephalogram and electromyogram (EMG) recordings were performed to define active waking, quiet sleep, and paradoxical sleep. Cardiac autonomic activity was measured by analyzing the power spectrum of heart rate variability. Central sleep apnea events were measured by analyzing the EMG recordings of the diaphragm. Results: In the LCA ligation group, there was a higher low-frequency (LF)/high-frequency (HF) power ratio during sleep; the LF/HF ratio decreased significantly in the rats that underwent RDN in all sleep stages when compared with that in the rats that did not. The frequency of sleep interruptions increased without RDN in the LCA ligation group when compared with that in the sham group. This change was ameliorated and prevented with RDN in the LCA ligation group.Conclusions: Our results demonstrate significant sleep fragmentation with sympathetic hyperactivity after MI and that RDN prevents autonomic dysfunction and disordered sleep. RDN may then reduce sleep apnea and sleep-related sudden cardiac death after MI by restoring autonomic homeostasis.(c) 2022 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier

    Advancement in the contemporary clinical diagnosis and treatment strategies of insomnia disorder

    Paul, SoumiVidusha, KaravadiThilagar, SivasudhaLakshmanan, Dinesh Kumar...
    17页
    查看更多>>摘要：This review is intended to provide an updated summary of, but not limited to, classification, etiopathogenesis, diagnosis, and treatment strategies for insomnia disorder. The severity of insomnia symptoms irrespective of co-existing primary medical condition/s in the studied patients classified insomnia as 'insomnia disorder' to prioritize the clinical attention on insomnia (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition). The frequency and duration of symptoms further divided insomnia into chronic, short-term, and other insomnia disorder (International Classification of Sleep Disorders, Third Edition). This disorder is a phenomenal state of hyperarousal developed and perpetuated by environmental, behavioral, cognitive, genetic, socioeconomic, preexisting medical factors. Overarching physiological, cortical, behavioral, and cognition changes in hyperarousal manifest insomnia disorder. It, sometimes, leads to the co-occurrence of other chronic medical condition/s. The contemporary diagnosis of insomnia disorder needs to consider modified diagnostic criteria, growing evidence on insomnia disorder symptoms, associated factors, co-existing medical condition/s (if any) to identify the subjective severity of insomnia disorder and design a treatment plan. The recommended treatment strategies include cognitive-behavioral therapy for insomnia (CBTI) and pharmacotherapy. However, CBTI lacks accessibility, qualified facilitators, and pharmacotherapy has limitations like side effects, physiological tolerance/dependence. The investigation of phytocompounds subdued these drawbacks of existing treatments as some compounds showed anti-insomniac potential. Furthermore, complementary alternative medicines (CAMs) like mindfulness-based practices, acupuncture, listening to music, Yogasanas, Pranayama, digital cognitive behavioral therapy for insomnia (dCBTI) during bedtime proved supportive in insomnia disorder treatment. (c) 2022 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier

    Effectiveness of technology-based interventions for improving sleep among children: a systematic review and meta-analysis

    Zhu, HongruiXiao, LinTu, Aixian
    10页
    查看更多>>摘要：Objective: The aim of this systematic review and meta-analysis was to analyze the characteristics and effectiveness of technology-based interventions in improving children sleep. Methods: PubMed, Embase, PsycInfo, CENTRAL and Web of Science were searched to identify research articles published until 11 August 2021. The protocol for this study was registered with PROSPERO (CRD42021272348). Articles screening, data extraction and quality assessment were carried out by two independent reviewers. Results: In total, the search generated 4597 studies. Of these, 15 studies (8 RCTs, 1 non-randomized control study and 6 pre-post studies) met our inclusion criteria. The meta-analysis indicated that technology-based interventions significantly increased the TST (SMD = 0.21, 95% CI = 0.06, 0.37; P = 0.007) and SE (SMD = 0.52, 95% CI = 0.17, 0.87; P = 0.003), and significantly decreased the SOL (SMD =-0.30, 95% CI =-0.47,-0.12; P = 0.001) and WASO (SMD =-0.33, 95% CI =-0.59,-0.07; P = 0.012). Conclusion: This systematic review and meta-analysis suggests that technology-based interventions may be effective at improving children sleep due to the advantages of online intervention. Further researches are needed to establish which technology components are most effective in improving children sleep, as well as explore better methods for increasing consistency of participation and accuracy of outcome evaluation. (c) 2022 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier

    COVID-19: a 21st century cataclysmic pandemic

    Becker, Philip M.Chokroverty, Sudhansu
    3页
      原文链接:
    • NSTL
    • Elsevier

    Relationships between the changes in sleep patterns and sleep quality among Chinese people during the 2019 coronavirus disease outbreak

    Liu, ShuaiLin, YanmeiLi, ShuangyanZuo, Heming...
    7页
    查看更多>>摘要：Objective: Rapidly increasing numbers of confirmed cases and deaths during the 2019 coronavirus disease outbreak (COVID-19) resulted in widespread psychological problems in the Chinese population. The purpose of this study was to investigate the sleep quality and changes in sleep patterns before and during the outbreak in the general population in China and to determine factors related to sleep quality. Methods: This cross-sectional study was conducted using an online questionnaire from 20 February to 29 February 2020 in China. Socio-demographic data, self-designed COVID-19-related characteristics, sleep patterns, and Pittsburgh Sleep Quality Index (PSQI) scores were obtained. Single factor analysis and multivariate binary logistic regression analysis were used. Results: A total of 1897 individuals were included in our study, and 30.0% of participants reported suffering poor sleep quality (PSQI>8). Logistic regression analysis found that the factors related to sleep quality included poor physical health (OR = 3.382, p < 0.001), respiratory disease (OR =1.629, p = 0.008), other diseases (OR = 2.504, p = 0.012), suspected case of COVID-19 in the same community (OR = 1.928, p = 0.002), confirmed case of COVID-19 in the same community (OR = 2.183, p = 0.007), worry about being infected (OR = 2.336, p < 0.001), >1 h/day spent hearing COVID-19 information (OR = 1.960, p < 0.001), time difference in midpoint time in bed (OR =1.230, p < 0.001), and time difference in time in bed (OR = 0.711, p < 0.001). Conclusions: Our study revealed that more than one-fourth of the participants suffered poor sleep quality during the COVID-19 outbreak. In addition to the poor health status and COVID-19-related anxiety, delayed sleep phase and reduced time in bed impacted sleep quality in the general population in China.(c) 2021 Elsevier B.V. All rights reserved.
      原文链接:
    • NSTL
    • Elsevier