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Journal of clinical neuroscience
Churchill Livingstone
Journal of clinical neuroscience

Churchill Livingstone

0967-5868

Journal of clinical neuroscience/Journal Journal of clinical neuroscienceSSCISCIISTPAHCI
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    Age at onset in patients with Lennox-Gastaut syndrome: Correlations with clinical manifestations

    Asadi-Pooya A.A.Farazdaghi M.
    5页
    查看更多>>摘要：? 2022 Elsevier LtdThe aim of the current study was to investigate the age at onset in patients with Lennox-Gastaut Syndrome (LGS). We also investigated the clinical and EEG characteristics of these patients in different age groups. This was a retrospective study. All patients with a diagnosis of LGS were recruited at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 through 2020. 300 patients had LGS. Age at onset was 3.3 ± 4.1 years (minimum = 0 and maximum = 21 years). In 10 patients (3%) LGS started at age 14 years or above. Epileptic spasms were more often observed in those with an age at onset below one year (8%) compared with those with an age at onset of 1 to 8 years (0.7%) [Odds Ratio (OR) = 10.32]. Intellectual disability was less frequently observed in those with an age at onset of 8 years and above (68%) compared with those with an age at onset of 1 to 8 years (90%) (OR = 0.33). Tonic-clonic seizures were more often observed in those with an age at onset of 8 years and above (83%) compared with those with an age at onset of 1 to 8 years (55%) (OR = 2.87). While age at onset of LGS in the majority of patients is below 8 years, in some patients the syndrome begins in their late childhood or even during adolescence. Age at onset of LGS has significant correlations with the clinical manifestations of the syndrome.
      原文链接:
    • NSTL
    • Elsevier

    Utility of automated MRI perfusion (RAPID) with or without MR angiography for detection of angiographic vasospasm after aneurysmal subarachnoid hemorrhage

    Sastry R.A.Bajaj A.Shaaya E.A.Anderson M.N....
    5页
    查看更多>>摘要：? 2022Delayed cerebral ischemia (DCI) is a major etiology of poor neurologic outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Although the development of DCI is certainly multifactorial, the presence of vasospasm is strongly correlated with it. Cerebral angiography remains the gold standard for evaluation of vasospasm, though it is not always practical or cost-effective. In this study, the authors assess the utility of automated MRI Perfusion imaging, with or without MR Angiography (MRA), as a confirmatory tool for suspected angiographic vasospasm. All patients admitted to a single institution with aneurysmal subarachnoid hemorrhage between January 2014 and February 2020 and who underwent MR Perfusion imaging with or without MRA for suspected vasospasm no >24 h prior to an angiogram were identified. 43 subjects were identified. 29 of these patients (67%) underwent simultaneous MRA. 25 patients (53%) received intra-arterial treatment for symptomatic vasospasm. The sensitivity, specificity, PPV, and NPV of MR Perfusion were 43%, 82%, 53%, and 75% for any angiographic vasospasm and 57%, 81%, 42%, and 89% for treated vasospasm. The sensitivity, specificity, PPV, and NPV of MR Perfusion in conjunction with MRA were 61%, 81%, 59%, and 82% for any angiographic vasospasm and 62%, 74%, 35%, and 89% for treated vasospasm. The sensitivity, specificity, PPV, and NPV of transcranial Dopplers (TCDs) in these patients were 35%, 93%, 71%, and 75% for angiographic vasospasm and 42%, 90%, 47%, and 88% for treated vasospasm. Automated MR Perfusion imaging demonstrated relatively low sensitivity and PPV for detection of angiographic and treated vasospasm in this subset of patients after aSAH.
      原文链接:
    • NSTL
    • Elsevier

    Postoperative spinal deformity and instability after cervical spinal cord tumor resection in adults: A systematic review and meta-analysis

    Noh S.H.Takahashi T.Inoue T.Park S.-M....
    7页
    查看更多>>摘要：? 2022 Elsevier LtdObjective: To investigate the incidence of cervical spine deformity and instability after posterior cervical spinal cord tumor (CSCT) resection without fusion or fixation in adults and examine relevant risk factors by reviewing and summarizing previously reported studies. Methods: We selected peer reviewed articles published between January 1990 and December 2020 from the MEDLINE and Cochrane Library databases using relevant key words. Articles in which the authors mainly described spinal cord tumor resection through posterior surgery without fusion or fixation in adults were selected for analysis. Patient's data including age, sex, extensive number of laminectomy levels, laminectomy at C2, C3, or C7, multilevel facetectomy, facet destruction, preoperative cervical kyphosis, and preoperative motor deficit were documented. Comparable factors were assessed using the odds ratio (OR) and weighted mean difference (WMD) of 95% confidence intervals (CI). Results: Among 133 articles identified, 18 met selection criteria. Overall incidence of deformity and instability after CSCT surgery was 0%–41.7% and 0%–20.5%, respectively. Younger age (WMD, ?5.5; 95% CI, ?10.52 ～ ?0.49; P = 0.03), C2 laminectomy (OR, 5.33; 95% CI, 2.39 ～ 11.91; P < 0.0001), more laminectomy level (WMD, 2.77; 95% CI, 1.78 ～ 3.76; P < 0.00001) were identified as risk factors for deformity and instability after CSCT surgery. Conclusion: Patients undergoing CSCT resection should receive careful follow-up for postoperative spinal deformity and instability. Younger age, C2 laminectomy, and more laminectomy level were significantly associated with occurrence of deformity and instability after CSCT surgery. Upfront spinal fixation at the time of resection should be considered in selected patients.
      原文链接:
    • NSTL
    • Elsevier

    A review of imaging genetics in Alzheimer's disease

    Xin Y.Sheng J.Miao M.Wang L....
    9页
    查看更多>>摘要：? 2022 Elsevier LtdDetermining the association between genetic variation and phenotype is a key step to study the mechanism of Alzheimer's disease (AD), laying the foundation for studying drug therapies and biomarkers. AD is the most common type of dementia in the aged population. At present, three early-onset AD genes (APP, PSEN1, PSEN2) and one late-onset AD susceptibility gene apolipoprotein E (APOE) have been determined. However, the pathogenesis of AD remains unknown. Imaging genetics, an emerging interdisciplinary field, is able to reveal the complex mechanisms from the genetic level to human cognition and mental disorders via macroscopic intermediates. This paper reviews methods of establishing genotype-phenotype to explore correlations, including sparse canonical correlation analysis, sparse reduced rank regression, sparse partial least squares and so on. We found that most research work did poorly in supervised learning and exploring the nonlinear relationship between SNP-QT.
      原文链接:
    • NSTL
    • Elsevier

    Establishing collaborations in global neurosurgery: The role of InterSurgeon

    Maleknia P.Shlobin N.A.Johnston J.M.Rosseau G....
    5页
    查看更多>>摘要：? 2022 The Author(s)The global deficiency in surgical care has been highlighted in the past several years, through the publication of the Lancet Commission on Global Surgery in 2015, the passage of WHA Resolution 68.15, and concerted efforts by advocacy organizations such as the G4 Alliance. Approximately 23,300 additional neurosurgeons are estimated to be needed to address the greater than 5 million essential neurosurgical cases that are not performed annually, most in low- and middle-income countries (LMICs). However, increasing recognition of the ease and feasibility of virtual technology prompted a shift towards virtual modes of communication. InterSurgeon (https://www.intersurgeon.org/), an independent, internet-based social network platform, has allowed for formal connection between global surgery advocates who may have complementary needs and resources. This manuscript aims to: 1) characterize the current progress of InterSurgeon, 2) describe lessons learned from the creation and use of InterSurgeon, and 3) discuss future directions for InterSurgeon. Equitable, well-designed collaborations are central to progress in global neurosurgery. InterSurgeon has catalyzed collaborations within global neurosurgery across world regions and country income status. In addition to its role in facilitating traditional in person collaborations, InterSurgeon will become an increasingly important tool for connecting surgeons worldwide as virtual collaboration and augmented reality training paradigms become important components of global surgery capacity building.
      原文链接:
    • NSTL
    • Elsevier

    Elevated spermidine serum levels in mild cognitive impairment, a potential biomarker of progression to Alzheimer dementia, a pilot study

    Sternberg Z.Podolsky R.Nir A.Yu J....
    6页
    查看更多>>摘要：? 2022Background/aims: There is a close link between iron and polyamine biosynthesis and metabolism. In a recent study, we reported alterations in the serum levels of hepcidin and other iron-related proteins in Alzheimer's disease (AD) patients (Sternberg et al., 2017). Based on these findings, this pilot study compared serum levels of one of the polyamines, Spermidine, between AD, mild cognitive impairment (MCI), and control subjects, correlating the levels with the existing clinical and neuroimaging data. Methods: This cross-sectional study measured Spermidine levels in frozen serum samples of 43 AD patients, 12 MCI patients, and 21 age-matched controls, provided by the Oregon Alzheimer's Disease Center Bio-repository, using enzyme-linked immunosorbent assay. Results: MCI patients showed significantly higher mean Spermidine serum levels compared to controls (P = 0.01), with a non-significant trend for higher Spermidine serum levels in pure AD (P = 0.08) participants compared to controls. Spermidine serum levels correlated with the values of cognitive assessment tests including MMSE (r = -0.705, P = 0.003), CDR (r = 0.751, P = 0.002), and CDR-SOB (r = 0.704, P = 0.007), in “pure” AD subgroup, suggesting that higher Spermidine serum levels in MCI can be a potential biomarker of conversion to dementia in subjects with AD underlying pathology. Furthermore, Spermidine serum levels correlated with serum levels of the chief iron regulatory protein, hepcidin in AD participants with a more advanced disease stage, indicated by MMSE (strata of 8–19, P = 0.02), and CDR-SOB (strata of 6–12, P = 0.03). Conclusion: Studies with larger cohort are warranted for defining the role of Spermidine in AD pathophysiology, and the utility of polyamines as biomarkers of progression of MCI to AD.
      原文链接:
    • NSTL
    • Elsevier

    Language is brain: Improving neurologic health equity for linguistically diverse populations

    Ortega P.Butler M.Cooper J.J.
    5页
    查看更多>>摘要：? 2022 Elsevier LtdNeurologic clinical care requires that clinicians gather and synthesize complex information, including a thorough, precise history and a detailed physical examination that maximizes the patient's cooperation. Yet, for patients who do not speak the dominant language in the country or region where they live, effective communication with their clinician may not always occur. In this article, we discuss the impact of language on neurologic care, focusing on access to care and on the diagnosis and treatment of two common and potentially life-threatening conditions: stroke and epilepsy. We then review implications for clinical neurologic care as well as medical education and present evidence-based recommendations for improving neurologic health equity for linguistically diverse populations. Strategies should integrate professional medical interpreters (for oral communication) and translators (for written materials) into the neurologic team, account for families and caregivers in a culturally humble manner, and teach learners to apply clinical neurologic skills in both language-concordant and discordant situations.
      原文链接:
    • NSTL
    • Elsevier

    Inter-device reliability of the NPi-200 and NPi-300 pupillometers

    Stutzman S.Iype P.Marshall J.Speir K....
    4页
    查看更多>>摘要：? 2022 Elsevier LtdThe pupillary evaluation is an essential part of the neurological examination. Research suggests that the traditional examination of the pupil with a handheld flashlight has limited interrater reliability. Automated pupillometers were developed to provide an objective scoring of various pupillary parameters. The NPi-200 pupillometer is used for quantitative pupillary examinations, the NPi-300 was launched in July 2021 with enhanced features. The purpose of this study is to compare results from the NPi-200 to the NPi-300 to ensure that data are translatable across both platforms. This study examines the inter-device reliability of the NPi-200 compared to the NPi-300 in two cohorts: 20 patients at risk for cerebral edema and 50 healthy controls. Paired assessments of the devices were made from all participants. Each assessment included bilateral PLR readings within a 5-minute interval. Data showed high agreement between the two devices for the Neurological Pupil Index (NPi) reading (k = 0.94; CI: 0.91–0.99) and for pupil diameter assessment (k = 0.91; CI: 0.87–0.96). There is a very high level of agreement between the NPi-200 and NPi-300 among healthy controls and critically ill patients. Clinicians and researchers can interpret the results from either device equally.
      原文链接:
    • NSTL
    • Elsevier

    Effect of concurrent transcranial direct current stimulation on instrumented timed up and go task performance in people with Parkinson's disease: A double-blind and cross-over study

    Mishra R.K.Thrasher A.T.
    8页
    查看更多>>摘要：? 2022 Elsevier LtdTranscranial direct current stimulation (tDCS) delivered to the dorsolateral prefrontal cortex (DLPFC) can improve mobility among people with Parkinson's disease (PD). Previous studies suggest that delivering tDCS during task performance might be beneficial. However, only a few studies explored the effect of combining tDCS with task. We investigated the effect of stimulating the DLPFC using anodal tDCS while performing a timed up and go (TUG) test and its sustained effects. In this sham-controlled, cross-over, and double-blind study, twenty participants with PD (age = 67.8 ± 8.3 years and 6 females) completed two sessions (anodal or sham tDCS), conducted in the randomized and counterbalanced manner, with at least a 1-week gap. Stimulation involved transferring 2 mA current through the DLPFC for 30 min. Single-trial of TUG test was performed under single- and dual-task conditions before, during, immediately after, 15 and 30 min after stimulation ceased. We estimated durations of completing different components of TUG. Phoneme verbal fluency task was given as the cognitive distractor during the dual-tasking. An improvement was observed in cognitive performance due to the tDCS condition (d = 0.7, p < 0.01) over time. However, we found no effect of tDCS condition on iTUG related outcomes under single- or dual-task conditions. In conclusion, DLPFC stimulation combined with task improved cognitive performance only, and the improvement was sustained after tDCS ceased. Future studies may investigate stimulating multiple brain regions to improve motor and cognitive performance.
      原文链接:
    • NSTL
    • Elsevier

    Correlation between serum 25(OH)D and cognitive impairment in Parkinson's disease

    Wu H.Khuram Raza H.Li Z.Zu J....
    4页
    查看更多>>摘要：? 2022This study aimed to investigate the relationship between serum 25(OH)D and cognitive impairment in patients with Parkinson's disease (PD), hoping to provide possible ideas for the diagnosis and prevention of PD with cognitive impairment. Vitamin D is a neurosteroid with neurotrophic and neuroprotective functions, playing an important role in PD and its progression. In the present study, serum 25(OH)D levels were significantly decreased in PD patients (45.86 ± 14.81 nmol/L)compared to healthy controls(56.54 ± 14.00 nmol/L) (P < 0.001), and significant differences were also observed in PD patients with normal cognition (PD-NC), PD patients with mild cognitive impairment (PD-MCI)and PD patients with dementia (PDD)(P < 0.05). Moreover, there was a positive correlation between serum 25(OH)D levels and Montreal cognitive assessment(MoCA) scores (r = 0.489,P < 0.001).The increased serum 25(OH)D was an independent protective factor of cognitive impairment in PD (OR = 0. 949, P = 0.005), and the sensitivity, specificity, and AUC under the ROC curve area of serum 25(OH)D were 53.3%, 86.5%, and 0.713, respectively. These findings support the relationship between cognitive impairment and Vitamin D in PD patients. Serum 25(OH)D may be a useful biomarker for diagnosing cognitive impairment in patients with PD.
      原文链接:
    • NSTL
    • Elsevier