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Journal of clinical neuroscience
Churchill Livingstone
Journal of clinical neuroscience

Churchill Livingstone

0967-5868

Journal of clinical neuroscience/Journal Journal of clinical neuroscienceSSCISCIISTPAHCI
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    Bony fixation in the era of spinal robotics: A systematic review and meta-analysis

    Himstead, Alexander S.Shahrestani, ShaneBrown, Nolan J.Produturi, Gautam...
    13页
    查看更多>>摘要:Background: Accurate spinal screw placement in spinal instrumentation is of utmost importance to avoid injury to surrounding neurovascular structures. This study was performed to investigate differences in accuracy, operating room time, length of stay, and operative blood loss across studies involving all types of spinal fixation. Methods: PubMed, EMBASE, and Scopus were systematically queried to identify articles that fit the inclusion and exclusion criteria. Meta-analysis was performed using R software, and odds ratios and 95% CIs were calculated. Results: Sixty-nine articles were included in qualitative synthesis, and 35 studies in the meta-analysis, for a total of 8,174 robotically placed screws in 1,492 patients compared to 9,791 conventionally placed screws in 1,638 patients. A total of 9 screw trajectories were studied in the literature, although only 4 had enough evidence to be included in the meta-analysis. Robotic screw placement was more accurate than conventional screw placement (OR 2.24; 95% CI, 1.71-2.94). Robotic placement was not associated with significantly different postoperative length of stay (SMD-0.32; 95% CI,-1.20, 0.51), operative blood loss (SMD-0.25; 95% CI,-0.79, 0.19), or operative duration (SMD 0.08; 95% CI-1.00, 1.39). A total of 8 robotic platforms were found in the literature with accuracy rates above 93%. Conclusion: Robotic spinal fixation is associated with increased screw placement accuracy and similar operative blood loss, length of stay, and operative duration. These findings support the safety and cost-effectiveness of robotic spinal surgery across the spectrum of robotic systems and screw types. (c) 2022 Elsevier Ltd. All rights reserved.

    Preoperative plasma D-dimer level may be predictive for success of cerebral reperfusion and outcome after emergency mechanical thrombectomy for intracranial large vessel occlusion

    Ohbuchi, HidenoriKanazawa, RyuzaburoHagiwara, ShinjiArai, Naoyuki...
    7页
    查看更多>>摘要:Presented retrospective analysis evaluated whether preoperative plasma D-dimer level may predict the success of cerebral reperfusion and outcome after emergency mechanical thrombectomy (MT) for intracranial large vessel occlusion (ILVO). Study cohort comprised 121 patients (mean age, 76 +/- 12 years) from two participating centers. ILVO mostly affected the M1 segment (48 cases) and internal carotid artery (ICA; 37 cases). Mean preoperative National Institutes of Health Stroke Scale (NIHSS) score was 18 +/- 8. Mean preoperative plasma D-dimer level was 4.4 +/- 6.6 mu g/ml. In 88 patients (73%) MT resulted in successful cerebral reperfusion. Multivariate analysis revealed independent associations of non-successful cerebral reperfusion with preoperative plasma D-dimer level > 6.7 mu g/ml (P = 0.0021), location of ILVO other than ICA (P = 0.0056), and prolonged antiplatelet or anticoagulant therapy before stroke onset (P = 0.0172). Plasma D-dimer level <= 6.7 mu g/ml predicted successful cerebral reperfusion with 0.91 sensitivity and 0.36 specificity. In 39 patients (32%) treatment resulted in favorable outcome. Multivariate analysis revealed independent associations of the unfavorable outcome with non-successful cerebral reperfusion after MT (P = 0.0005), preoperative plasma D-dimer level > 1.9 mu g/ml (P = 0.0131), higher preoperative NIHSS score (P = 0.0171), and chronic arterial hypertension before stroke onset (P = 0.0254). Plasma D-dimer level <= 1.9 mu g/ml predicted favorable outcome with 0.64 sensitivity and 0.62 specificity. In conclusion, preoperative plasma D-dimer level may be predictive for success of cerebral reperfusion and outcome after emergency MT for ILVO, which may be potentially helpful for prediction of prognosis in selected treatment candidates. (C) 2022 Elsevier Ltd. All rights reserved.

    3D volumetric evaluation of the diagnosis and severity of carpal tunnel syndrome using MRI

    Oten, ErolUgur, Levent
    5页
    查看更多>>摘要:Background: Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome. The usage of clinical tests and nerve conduction studies (NCS), as well as ultrasonography and magnetic resonance images (MRI), have recently become widespread to diagnose CTS. This study aims to determine the alteration of the carpal tunnel volume based on disease seriousness by MIMICS 19.0 which is a threedimensional modeling software. Materials and method: In this study, 80 wrists of 63 (47 female and 16 male) patients with MRI and NCS results among 1252 patients who applied to our hospital with wrist pain and neuropathic complaints between January 2019 and August 2020 were included in our study. The patients were classified into four groups according to their NCS results as normal, mild CTS, moderate CTS, and severe CTS. Carpal tunnel volumes of the groups were measured with MIMICS 19.0 program using MRI. Three-dimensional carpal tunnel volume averages were statistically compared between the groups. Then, all statistical analyzes were performed using SPSS (Statistical Package for Social Sciences, version 23) software. Results: The results demonstrate the mean carpal tunnel volume values for normal, mild CTS, moderate CTS, and severe CTS are 5.51 cm3 +/- 0.20, 5.27 cm3 +/- 0.16, 4.86 cm3 +/- 0.20, and 4.43 cm3 +/- 0.24, respectively. Carpal tunnel volumes were found to be lower in all groups which have CTS compared to the normal group. As the groups with CTS were compared among themselves, a significant difference was found between the groups in terms of carpal tunnel volumes (p < 0.001). Conclusions: In this study, a significant relationship between 3-dimensional measurements of carpal tunnel volume and the severity of CTS was observed. Therefore, MRI is an applicable method to diagnose and determine the severity of CTS.

    The impacts of masks and disinfectants on migraine patients in the COVID-19 pandemic

    Yuksel, HaticeKenar, Safiye GulGursoy, Gorkem TutalBektas, Hesna...
    6页
    查看更多>>摘要:Since the onset of the COVID-19 pandemic, the use of personal protective equipment (PPE) and disinfectants has become necessary to prevent transmission of the virus. However, the effects of such pandemic obligations on chronic diseases such as migraine have not been fully elucidated. We aimed to investigate the effects of the COVID-19 pandemic, as well as the use of masks and disinfectants, on migraine patients. A total of 310 migraine patients were included. Demographic data, migraine characteristics, and mask and disinfectant use were obtained through a face-to-face survey. Patients were grouped as worsening, stable, or improving according to pre-pandemic and pandemic migraine characteristics. Migraine worsening was found in 177 (57.1%) patients, stable course in 96 (31%) patients, and improvement in 37 (11.9%) patients. The use of scalp contact masks and double masks and daily mask duration were higher in the worsening group (p:0.005, p:0.005 and p:0.001). In addition, the frequency of personal disinfectant use was higher in this group (p:0.011). In regression analysis, mask type, daily mask duration, presence of allodynia, being a health worker, depression score, and odor were determined as independent risk factors for migraine worsening. We found a worsening of migraines in more than half of patients during the COVID-19 pandemic. We also demonstrated a relationship between migraine worsening and mask type, number of masks, and intensive disinfectant use. Migraine patients should be advised of optimal prevention methods based on individual social and working conditions rather than exaggerated preventative measures. (c) 2022 Elsevier Ltd. All rights reserved.

    study Plateaus and reversals evaluated by different methods in patients with limb-onset amyotrophic lateral sclerosis

    Hu, NanYang, XunzheCui, LiyingLiu, Mingsheng...
    6页
    查看更多>>摘要:Objective: To determine the difference in frequency of amyotrophic lateral sclerosis (ALS) reversals and plateaus in limb-onset patients evaluated with different methods. Methods: One hundred and eighteen patients with limb-onset ALS were prospectively recruited. ALS Functional rating scale-revised (ALSFRS-R) score, total Medical Research Council (MRC) muscle strength -score and clinical global impression (CGI) score were followed up every three months for at least 1 year. The changes between two follow-up points in scores were analyzed. Results: Reversal and plateau in ALSFRS-R score were detected in 26.14% patients between initial and 3-month, 21.19% between 3-month and 6-month, 23.73% between 6-month and 9-month, 19.49% between 9-month and 12-month, respectively. For total MRC muscle score, the percentages were 28.81%, 21.19%, 16.95%, 13.56%, respectively. For CGI score, the percentages were 74.57%, 64.41%, 66.10%, 66.95%, respec-tively. There was significant difference in the frequency of plateau or reversal between ALSFRS-R scale and total MRC scale over 3-month interval visit (P < 0.05), while no significant difference was revealed between CGI scale and ALSFRS-R scale or total MRC scale. The frequency of reversal and plateau were 8.47% at 6-month, 4.24% at 9-month, 3.34% at the last follow-up in both ALSFRS-R score and total MRC score, respectively. Conclusion: Plateaus and reversals in ALSFRS-R score, total MRC score and CGI score are not uncommon in limb-onset patients during follow-up. The combination of ALSFRS-R score and total MRC score could bet -ter reflect the relentless progression of ALS. The importance of long-interval follow-up should be stressed in clinical practice. (c) 2022 Elsevier Ltd. All rights reserved.

    The Insurance Coverage Paradox - Characterizing Outcomes among Dual-Eligible Hemorrhagic Stroke Patients

    Perla, Krissia M. RiveraPerez, Giancarlo MedinaJean-Charles, SkendaTang, Oliver...
    7页
    查看更多>>摘要:Background: Socioeconomic factors, such as insurance status, have been shown to affect outcomes for patients following emergency injuries. Dual-eligible beneficiaries, receiving both Medicare and Medicaid, constitute an especially vulnerable population. There is limited data addressing whether dual-eligible beneficiaries with hemorrhagic stroke display unique characteristics and outcomes compared to patients with Medicare, Medicaid, or private insurance. Study design: We conducted a retrospective analysis of 10-years of National Inpatient Sample data. Using ICD-9-CM codes, we identified adult patients with known insurance status who were emergently hospitalized for intracranial hemorrhage; epidural, subdural, subarachnoid, and intracerebral hemorrhages were included. Patient characteristics including whether they underwent surgical intervention were collected. Multivariable logistic regression was used to adjust for confounders. Primary clinical outcomes of interest included mortality (in-hospital), complications (any), and favorable discharge (home/home with services). Results: Among 410,621 patients, dual-eligible (6.8%) patients were on average older (mean age = 73yrs) compared to Medicaid (46yrs), private insurance (67yrs), or no-charge (47yrs) patients. Caucasian race was highest among Medicare patients (83%) while African-American race was highest among Medicaid (22%). Among all patients, 5.3% underwent operative intervention. Dual-eligibles had significantly higher odds of in-hospital mortality compared to no-charge (adjusted odds ratio (aOR) = 1.61, 95% CI = [1.04 - 2.49]), but no significant difference between Medicare and Medicaid although dual-eligibles. Dualeligibles had significantly increased odds of complications compared to Medicaid (aOR = 1.23, 95% CI = [1.11 - 1.37]) and privately insured patients (aOR = 1.19, 95% CI = [1.11 - 1.28]), both p < 0.001, and lower odds of favorable discharge compared to all other groups, all p < 0.001. Dual-eligibles underwent a shorter length of stay, an 18% decrease, compared to Medicaid patients (fl-Coefficient = 0.82, 95% CI = [0.78 - 0.86], p < 0.001), and inflation adjusted admission costs that were 24% lower compared to Medicaid patients (fl-Coefficient = 0.76, 95% CI = [0.73 - 0.80], p < 0.001), amounting to a $3,684 decrease in cost. Conclusions: Dual-eligible beneficiaries experience unique health disparities from lower odds of favorable discharge to increased odds of complications and in-hospital mortality compared to other insured and uninsured groups. Adverse outcomes among dual-eligible beneficiaries highlight the need to uncover and address unknown sources of disparities to improve emergency treatment of hemorrhagic stroke in this population.

    Post-COVID 19 neurological syndrome: Are we facing a neuropsychiatric phenotype?

    Rubiano-Buitrago, Jose DavidRahiran-Ramirez, Angie FaizulyPena-Vargas, Diana MarcelaPaez-Rincon, Leidy Angelica...
    2页

    Minimally invasive surgery for intradural extramedullary spinal cord pathologies: A case series and technical note

    Kelly, RyanFayed, IslamConte, AnthonyRock, Mitchell...
    7页
    查看更多>>摘要:Background: Intradural spinal cord pathologies have traditionally been managed with open surgical procedures and require the completion of a durotomy. Minimally invasive techniques are emerging as alternative procedures with the goal of reducing complications, but often require specialized equipment with additional training. Methods: We conduct a single institution retrospective review from 2016 to 2019 of patients undergoing minimally invasive durotomy closure for intradural extramedullary pathologies using a novel technique that utilizes standard operating room equipment. This cohort is compared to a cohort of patients treated with a traditional open approach. Results: Patients treated with minimally invasive surgery (MIS) had no statistically significant differences in baseline characteristics compared to patients treated with open procedures. Patients treated with MIS had decreases in complication rates, estimated blood loss, and length of stay in the hospital compared to the patients treated with open procedures, but these differences did not reach levels of statistical significance. Conclusions: Our novel MIS technique for intradural extramedullary pathologies appears to be safe and effective in creating a watertight dural closure using standard operating room equipment, while avoiding the costs and training associated with specialized equipment and possibly improving surgical outcome measures when compared to open approaches.

    Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke

    Foroughinia, FarzanehMorovati, NajmehSafari, AnahidDianatpour, Mehdi...
    6页
    查看更多>>摘要:Background and aims: There have been plenty of reports regarding the association between Vitamin D (Vit D) and carotid atherosclerosis and stroke. We aimed to assess the association between FokI and TaqI polymorphisms of vitamin D receptor (VDR) gene and the severity of carotid bulb stenosis and the incidence of carotid bulb calcification in patients with ischemic stroke. Methods: This prospective study conducted at Shiraz University of Medical Sciences between February 2020 and August 2020. All consecutive patients with ischemic stroke with more than 50% carotid bulb stenosis in color doppler sonography underwent cervical CT angiography (CTA). Demographics, risk factors of ischemic stroke, serum calcium, phosphate, creatinine, serum 25-hydroxyvitamin D (Vit D) level were investigated by High-Performance Liquid Chromatography (HPLC) method. The severity of stenosis and presence of calcification in carotid bulb ipsilateral was studied in CTA to ischemic stroke. VDR genotypes of FokI and TaqI polymorphisms were determined by the Restriction Fragment Length Polymorphism (RFLP) method. Results: A total of 122 patients were recruited in this study (mean age: 59.1, 66.4% males, 17.2% with carotid artery stenosis of 70-99%. 57% with carotid bulb calcification). There was a significant association between calcification of carotid bulb with FokI CC polymorphisms of VDR gene (P value = 0.037). There was no significant relationship between the severity of carotid bulb stenosis and Fok1 and TaqI polymorphisms of vitamin D receptor gene and their alleles. Conclusions: There may be a biological association between the FokI VDR gene and carotid bulb calcification.

    Natural language processing for automated surveillance of intraoperative neuromonitoring in spine surgery

    Agaronnik, Nicole D.Kwok, AnneSchoenfeld, Andrew J.Lindvall, Charlotta...
    6页
    查看更多>>摘要:We sought to develop natural language processing (NLP) methods for automated detection and charac-terization of neuromonitoring documentation from free-text operative reports in patients undergoing spine surgery. We included 13,718 patients who received spine surgery at two tertiary academic medical centers between December 2000 - December 2020. We first validated a rule-based NLP method for iden-tifying operative reports containing neuromonitoring documentation, comparing performance to stan-dard administrative codes. We then trained a deep learning model in a subset of 993 patients to characterize neuromonitoring documentation and identify events indicating change in status or difficulty establishing baseline signals. Performance of the deep learning model was compared to gold-standard manual chart review. In our patient population, 3,606 (26.3%) patients had neuromonitoring documenta-tion identified using NLP. Our NLP method identified notes containing neuromonitoring documentation with an F1-score of 1.0, surpassing performance of standard administrative codes which had an F1-score of 0.64. In the subset of 993 patients used for training, validation, and testing a deep learning model, the prevalence of change in status was 6.5% and difficulty establishing neuromonitoring baseline signals was 6.6%. The deep learning model had an F1-score = 0.80 and AUC-ROC = 1.0 for identifying change in status, and an F1-score = 0.80 and AUC-ROC = 0.97 for identifying difficulty establishing baseline signals. Compared to gold standard manual chart review, our methodology has greater efficiency for identifying infrequent yet important types of neuromonitoring documentation. This method may facilitate large-scale quality improvement initiatives that require timely analysis of a large volume of EHRs.