Nix, CindyGhassemi, MaryamCrommen, JacquesFillet, Marianne...
11页查看更多>>摘要：Neurological disorders are one of the leading causes of disability and death worldwide. The complexity of the human brain and therefore the significant structural gap between animal models and humans, all serve to hinder translational success. Recent advances in microfluidic devices and human organ-on-a chip systems have provided new opportunities to study and monitor such diseases with the benefits of precise control, lower sample requirement and reagent consumption, cost-effectiveness and high throughput screening. Combined with biosensors, mass spectrometry or automatic imaging systems, they have emerged as a unique way to facilitate personalized medicine. To obtain relevant and reliable information, it is crucial to address the different challenges specific to each type of microfluidics device. In the following review, the discussion is focused on the technical setup of microfluidic devices for the detection of brain disorder biomarkers and on the microfluidics strategies that are applied to monitor neurological diseases. In the last section, we also discuss limitations, challenges and regulatory requirements that remain to be considered in future experiments.(c) 2022 Elsevier B.V. All rights reserved.
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NSTL
Elsevier
Gawronska, MalgorzataKowalik, MateuszMakowski, Mariusz
21页查看更多>>摘要：Ampicillin (AMP) is an antibiotic belonging to the b-lactam group, which exhibits a broad spectrum of action in preventing and treatment of various bacterial diseases. The overuse of antibiotics has led to the dissemination of multidrug resistance among pathogenic strains. Thus, many important drugs, including AMP, have lost their biological activity. Currently, the attention of researchers seem to be mostly attracted by the synthesis of new antibiotic drugs, the modification of existing drugs, and the complexation with metal ions, that can improve their biological properties. Moreover, residues of penicillin in food and the environment have received much attention in recent years because of growing concerns regarding food safety and public health. Therefore, the development of novel sensing materials and methods for the detection of antibiotics is also an important topic. This review summarizes recent research trends in the medicinal chemistry of AMP, including its synthesis, rapid and sensitive detection, and metal complexes.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
原文链接:- NSTL
- Elsevier
Phansi, PiyawanFerreira, Sergio L. C.Cerda, Victor
9页查看更多>>摘要：The aim of this work is to revise some programs, which are used to obtain accurate equilibrium constants using several chained programs. For this purpose, the AutoAnalysis software is very useful to perform the experimental work, including potentiometric titrations. The POTENtit program allows detecting some problems in the data obtained with AutoAnalysis along the experimental work, like the presence of metals in the sample and the carbonation of the titrant. This program also allows obtaining the standard potential of the working electrode, and the ionic product of the solvent under the used experimental ionic strength. Finally the MINIPOT program allows refining the results obtained, both for the calibration of the electrodes (E-0, j(H), J(OH), pK(s), and g) and for the constants equilibria (HqLp or MqLp). These three mentioned programs have been updated in order to run under the Windows 10 environment. (C) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Babaei, AbouzarPouremamali, AmirRafiee, NastaranSohrabi, Hessamaddin...
22页查看更多>>摘要：Viral infections are responsible for the deaths of millions of people throughout the world. Since outbreak of highly contagious and mutant viruses such as contemporary sars-cov-2 pandemic, has challenged the conventional diagnostic methods, the entity of a thoroughly sensitive, specific, rapid and inexpensive detecting technique with minimum level of false-positivity or -negativity, is desperately needed more than any time in the past decades. Biosensors as minimized devices could detect viruses in simple for-mats. So far, various nucleic acid, immune-and protein-based biosensors were designed and tested for recognizing the genome, antigen, or protein level of viruses, respectively; however, nucleic acid-based sensing techniques, which is the foundation of constructing genosensors, are preferred not only because of their ultra-sensitivity and applicability in the early stages of infections but also for their ability to differentiate various strains of the same virus. To date, the review articles related to genosensors are just confined to particular pathogenic diseases; In this regard, the present review covers comprehensive information of the research progress of the electrochemical, optical, and surface plasmon resonance (SPR) genosensors that applied for human viruses' diseases detection and also provides a well description of viruses' clinical importance, the conventional diagnosis approaches of viruses and their disadvantages. This review would address the limitations in the current developments as well as the future challenges involved in the successful construction of sensing approaches with the functionalized nanomaterials and also allow exploring into core-research works regarding this area.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
原文链接:- NSTL
- Elsevier
Guo, JiayingFang, BinBai, HuaWang, Limin...
23页查看更多>>摘要：As the "powerhouse" of the cells, mitochondria participate in numerous energy metabolism processes. Abnormal structure and function of mitochondria will affect the activities of living cell, leading to pathological changes including degenerative diseases, metabolic diseases, genetic diseases, and tumors. Early diagnosis and treatment of mitochondrial diseases are essential to improve the survival rate of patients. Therefore, rapid, sensitive and simultaneous detection of multiple analytes of mitochondrial diseases is of great importance for human health. In recent years, dual/multi-responsive fluorogenic probes (DMRFPs) with specific recognition functions and selective signal readout/conversion for analytes in mitochondria have been developed. In this review, we have summarized the recent advances in DMRFPs for analytes detection in mitochondria such as simultaneous detection of i) microenvironment and related analytes, ii) redox species and iii) other analytes in mitochondria and given a brief perspective on the design of DMRFPs and their applications to inspire the new generation of mitochondrial-targeting DMRFPs.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Jimenez-Rodrigues, Mildred G.Silva-Lance, FernandoParra-Arroyo, LizethMedina-Salazar, Alejandra...
13页查看更多>>摘要：Wastewater-Based Epidemiology (WBE) is a novel community-wide monitoring tool that provides comprehensive real-time data of the public and environmental health status and can contribute to public health interventions, including those related to infectious disease outbreaks (e.g., the ongoing COVID-19 pandemic). Nonetheless, municipalities without centralized laboratories are likely still not able to process WBE samples. Biosensors are a potentially cost-effective solution to monitor the development of diseases through WBE to prevent local outbreaks. This review discusses the economic and technical feasibility of eighteen recently developed biosensors for the detection and monitoring of infectious disease agents in wastewater, prospecting the prevention of future pandemics.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Karadurmus, LeylaBilge, SelvaSinag, AliOzkan, Sibel A....
8页查看更多>>摘要：Considering the global terrorist activities that have increased in the last decade, it is evident that the importance of explosives has increased significantly. For this reason, it is imperative and vital to detect explosive residues rapidly, reliably, and accurately. Recently, various methods have been widely used for the detection of explosives. While these techniques have their respective advantages, many have a significant problem with selectivity. As a result, many researchers turn to time-consuming, expensive, and multi-step solutions to solve this problem. Molecularly imprinted polymers (MIPs) can often provide excellent sensitivity and selectivity for the sensing of explosives. Considering the advantages of MIPs in sensing methods, advances in the development of explosive monitoring based on MIPs sensors were investigated in this review. Over the last ten years, we primarily focused on electrochemical, fluorescence, and chemiluminescence sensing based on MIPs in explosive analysis. In addition, brief information is given about which types of explosives were detected. (c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Schmidt, KatjaPaul, Sophie A. L.Achterberg, Eric P.
12页查看更多>>摘要：Geochemical behaviour and bioavailability of trace metals are closely related to their physical fractionation and chemical speciation. The DGT speciation technique allows the challenging assessment of labile concentrations of Mn, Cd, Cu, Ni, V, As, and rare earth elements and yttrium (REY) in ocean waters. In this first deep-water in situ study of DGT lability, we demonstrate the approach in bottom waters of the Clarion Clipperton Zone in the central NE Pacific. In the dissolved fraction (<0.2 mm), 70% to 100% of Cd, Ni, V, and REY, but only 25% of Cu and less than 50% of As were determined, reflecting their prevailing dominance of organic vs. inorganic complexation. This study demonstrates the applicability and sensitivity of DGT passive samplers for trace metals as a suitable technique for monitoring of anthropogenic activities, such as deep seabed mining, as well as for natural process studies in abyssal environments.(c) 2022 Published by Elsevier B.V.
原文链接:- NSTL
- Elsevier
Hu, JingLi, ChenghuiZhen, YafeiChen, Hanjiao...
14页查看更多>>摘要：The utilization of chemical vapor generation (CVG) as a sample introduction method for analytical atomic spectrometry has been an important subject of numerous studies for more than 50 years. The sustained interest in CVG is driven by not only the intrinsic advantages of this technique, but also the quest for even better detection power based on higher vapor generation efficiency and stronger anti-interference capability, as well as an expansion of the scope of CVG to encompass more detectable analytes. Historically, reduction by tetrahydroborates (THBs) appears to be the most successful for especially hydride forming elements, whereas interferences from transition metals, the in-depth characterization of the volatile species as well as practical applications can remain a hard nut to crack. For the past decade, several new types of CVG outperforming conventional hydride generation have been explored, which considerably promote the development of this technique in atomic spectrometric and non-atomic spectrometric areas. The objective of the present review is, on one hand, to assimilate the recent advances of CVG in non-THB media, with special attention paid to photochemical vapor generation and plasma-induced vapor generation; on the other hand, since a deep understanding in the mechanism of these CVGs is of utmost importance and broad interest to a sizable research community, with examples drawn from literature and our own recent work, the interpretation of the intermediates and resultant volatile products are also highlighted, along with characterization tools that could be beneficial for this purpose. We finally provide some insights into the directions for future CVG research for analytical chemistry.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Yin, FangchaoSu, WentaoWang, LiHu, Qiongzheng...
16页查看更多>>摘要：With growing interest in neurological diseases, treatment of neurodegenerative diseases such as Alzheimer's disease is crucial. However, drug development for nervous system diseases is still limited due to its inadequate permeation across the blood-brain barrier (BBB). The inherent complexity of brain structures prevents potential drugs reaching the cerebral targets, thereby limiting their efficacy. The microfluidic blood-brain barrier (BBB) models, evolved from tissue engineering and microfabrication technology, represent a technological breakthrough to facilitate biomedical research and drug discovery by recapitulating the main structural and functional complexity of the human BBB in vitro. In this review, key parameters determining the physiologically related microfluidic BBB models are presented. The current techniques for evaluating the integrity of the in vitro BBB models are highlighted, including testing for the presence of tight junction proteins, measurement of trans-epithelial electric resistance (TEER) and permeability of specific substances. Future opportunities and perspectives for developing the microfluidic BBB models to accelerate neuroscience and pharmaceutical research are also discussed.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
