Guo, JingxingLiu, YingJu, HuangxianLu, Guangming...
18页查看更多>>摘要：Surface-enhanced Raman scattering (SERS) owns high sensitivity, excellent selectivity and strong resistance to water and air, and can be used for nondestructive detection by portable equipment without tedious sample pretreatment. These merits make SERS an attractive choice for on-site analysis. Nowadays, more and more SERS-based sensing strategies have been established to increase the sensitivity and selectivity, as well as simplify operation processes and reduce testing cost for field analysis. These lead to the rapid development in research and commercialization. However, SERS-based on-site analysis is still in the early stage and needs to be further exploited. In this review, we summarize and evaluate the related works in recent five years from the aspect of analytical work flow, which consists of three parts: target signal collection, target signal amplification and target signal readout. Then, five different application scenes of these sensing strategies including medical diagnosis, environmental protection, food safety, forensic analysis and cultural relics protection are introduced, followed by the discussion of challenges and development tendency for future works. This comprehensive review will provide the design guidelines for researchers and engineers to explore novel testing strategies on field, which may eventually promote the launch of commercial products for our daily life. (c) 2021 Elsevier B.V. All rights reserved.
原文链接:
NSTL
Elsevier
Angel Aguirre, MiguelCanals, Antonio
13页查看更多>>摘要：Magnetic deep eutectic solvents (MDESs) have recently produced a torrent of pioneering applications in endless areas of sample preparation. By including a magnetic nanomaterial (e.g., magnetic nanoparticles) or a paramagnetic anion (e.g., [FeCl4](-)) in their structure, MDESs exhibit a strong response under the application of an external magnetic field. Furthermore, the use of MDESs, as a sorbent or solvent in extraction techniques, have been scarcely employed to develop green analytical methods, characterized by the avoid of time-consuming steps and the use of toxic organic solvents, as well as the application of small amounts of MDESs, for the determination of organic and inorganic contaminants, drugs, proteins, among others in environmental, food and biological matrices. This review highlights the application of MDESs in sample preparation in analytical chemistry. Challenges and future outlooks of new MDESs are also presented. (C) 2021 The Authors. Published by Elsevier B.V.
原文链接:- NSTL
- Elsevier
Zimna, AnnaBulat, KatarzynaBlat, AnetaStepanenko, Tetiana...
27页查看更多>>摘要：Application of modern and innovative spectroscopic and microscopic approaches to biomedical analysis opens new horizons and sheds new light on many unexplored scientific territories. In this review, we critically summarize up-to-date Raman-based methodologies for red blood cells (RBCs) analysis used in biology and medicine, and compare them with both classical, as well as other spectroscopic and microscopic approaches. The main emphasis is placed on the advantages, disadvantages and capabilities of each technique for detection of RBC deteriorations and RBC-related diseases. Although currently used classical techniques of medical analysts serve as a gold standard for clinicians in diagnosis of erythropathies, they provide insufficient insight into RBC alterations at the molecular level. In addition, there is a demand for non-destructive and label-free analytical techniques for rapid detection and diagnosis of erythropathies. Their recognition often requires multimodal methodology comprising application of methods including sophisticated spectroscopy-based techniques, where Raman-based approaches play an important role. (C) 2021 The Author(s). Published by Elsevier B.V.
原文链接:- NSTL
- Elsevier
Granborg, Jonatan RiberHandler, Anne MetteJanfelt, Christian
13页查看更多>>摘要：New mass spectrometry imaging (MSI) techniques are gaining importance in various stages of the drug discovery and development chain as well as in more fundamental studies of drug delivery. The advantage of MSI is that for an imaging technique, the selectivity is very high and as a label-free technique, it enables simultaneous and compound-specific imaging of drugs and their metabolites. In addition to that, a vast number of endogenous metabolites, which may serve as tissue biomarkers, can be imaged simultaneously, providing a very extensive characterization of the sample. The present review focusses on the application of MSI for imaging of drugs and their metabolites, primarily is studies of drug distribution and drug metabolism. The first half provides a quite general introduction to MSI with the main focus on MALDI-MSI and DESI-MSI, which are the two most commonly applied MSI techniques for pharmaceutical applications. It also has sections where the necessary sample preparation, including cryo-sectioning, is discussed, along with sections on data analysis and quantitative MSI, which in particular for pharmaceutical applications plays an increasingly significant role. The second half of the paper presents examples of pharmaceutical applications of MSI. The chapter does not contain an exhaustive list of all published studies, but should be considered a curated list of examples where MSI has contributed with information which cannot readily be obtained by conventional analytical techniques. The examples are chosen to represent diverse fields within drug delivery (local and systemic) and drug metabolism with examples from different organs and from whole-body studies. The final section presents a broader look at ongoing trends within MSI and some thoughts on where MSI is heading in the years to come. (C) 2021 The Author(s). Published by Elsevier B.V.
原文链接:- NSTL
- Elsevier
Suryanarayanan, RajBansal, Arvind K.
2页原文链接:- NSTL
- Elsevier
Saltepe, BehideWang, LeiWang, Baojun
12页查看更多>>摘要：Wastewater surveillance is a powerful tool to understand community profiling in terms of health monitoring. Tracking biomarkers such as inorganic and organic pollutants, drugs, and pathogens in wastewater gives a general idea about the lifestyle and health status of a population as well as pollutant exposure caused by various toxic chemicals. Notably, tracing pathogenic clues could help predict and prevent disease outbreaks such as the ongoing COVID-19 pandemic in communities. To this end, developing portable biosensing platforms will facilitate the on-site monitoring of water contamination without requiring complex equipment. New technological developments in synthetic biology have advanced both synthetic gene circuit-based biosensors and new in vitro detection strategies coupled with easy-to-interpret visualization methods. Here, we summarize the latest advances in synthetic biology tools and discuss how they enable the development of rapid, low-cost, ease-to-use and field-deployable biosensors for monitoring a variety of water contaminants and health-related biomarkers in the environment.(c) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Assis, Rosivan SantosBarreto, Jeferson AlvesBezerra, Marcos AlmeidaNovaes, Cleber Galvao...
12页查看更多>>摘要：In recent years, the search for the principles of green chemistry in analytical methods has grown considerably. In green analytical chemistry, solvents occupy an essential place. Some criteria are necessary for a solvent to be qualified as a green medium, such as availability, low toxicity, biodegradability, and low cost. So far, the number of green solvents available is quite limited. Many extraction techniques have emerged as alternatives to conventional extraction procedures, using green solvents. A new group of solvents known as deep eutectic solvents (DESs) has emerged as a new and promising alternative for substituting traditional solvents. DESs attract attention due to their peculiar characteristics: eco-friendly, inexpensive, and simple to obtain. This work presents a critical review involving DESs in liquid-phase microextraction (LPME) and their contributions to green chemistry. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Zhai, XinhuiChen, RongShen, Weiyang
20页查看更多>>摘要：Aggregation induced emission (ALE) organic luminescent materials have attracted extensive attention in many fields because of their unique properties. AIEgens have outstanding advantages such as high transmission efficiency, good signal amplification effect, good processability and multi-function. Nanofibers have the advantages of small pore size, large specific surface area and rich structure. They can be grafted with different functional substances or functional groups. Nanofibers combined with AIEgens have been widely used in sensors, environmental monitoring, bioanalysis, drug delivery, disease treatment and cell imaging. They have the advantages of good luminescence performance, high efficiency, good light stability, good biocompatibility and strong optical non-linearity. This article reviews the research progress in this field in recent years. The design and synthesis of AIEgens and ALE polymers, the luminescence mechanism of ALE, the preparation, advantages and importance of AIEgens-based nanofibers and their applications in biomedical therapy, drug delivery, sensors and cell imaging are summarized. Finally, the future development direction of nanofibers based on AIEgens is prospected. It is hoped that this review will provide an opportunity to promote the development of AIEgen based nanofibers in the future. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Jehlicka, JanEdwards, Howell G. M.Oren, Aharon
19页查看更多>>摘要：Raman spectroscopy allows the detection and discrimination between microbial pigments of different origins, including carotenoids, chlorophylls and less commonly found violet and brown non-photosynthetic pigments. This review reports examples of Raman spectroscopic studies on violet and brown pigments produced by microorganisms. Examples of investigations on the biological pigments scytonemin, gloeocapsin, violacein, phycocyanin, and prodigiosin are reviewed. Raman spectroscopy is a fast, simple and direct analytical tool which has been appreciated by microbiologists and chemists but more recently also by those who study natural geobiological processes in real-world systems. Different Raman spectroscopic approaches including confocal Raman spectrometry, FT-Raman spectroscopic possibilities, and SERS modes are reviewed for possibilities of following distribution of pigments at the cellular level in microbial cultures or in native endoliths, including confocal Raman spectrometry, FT-Raman spectroscopic possibilities, and SERS modes. New fast Raman mapping techniques are increas-ingly used, as well as portable systems. Special possibilities of high relevance for geoscience, geobiology or applied microbiology are opened up by the recent revolutionary technical developments, including the availability of portable and handheld tools that can be used directly on rocky outcrops to study native microbial colonization in situ.(c) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Lu, WenhuiChen, LingxinSong, ZhihuaLi, Jinhua...
19页查看更多>>摘要：Molecularly imprinted polymers (MIPs) possess selectivity toward template molecules and their structural analogues. Depending on the preparation approach (bulk polymerization, emulsion polymerization, suspension polymerization, etc.), essential elements (target compounds or template molecules, porogenic solvents, functional monomers, cross-linking agents and initiators) for MIPs synthesis and intended applications, various formats of MIPs having different morphologies and traits (monolithic, microbeads, thin film), can be easily obtained. Ameliorating the recognition selectivity and detection sensitivity of chromatographic techniques by using MIPs based stationary phases (SPs) is an influential and extensively developed strategy. Here, the recent progress in the design of MIPs based SPs is highlighted. The essential elements in preparation of MIPs based SPs are stated. The representative characterizations and applications of MIPs based SPs for chromatographic separation of pharmaceutical compounds, environmental pollutants and some compounds are outlined. Finally, the deficiencies and future perspectives of MIPs based SPs are discussed. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
