Weisser, JanaPohl, TeresaHeinzinger, MichaelIvleva, Natalia P....
15页查看更多>>摘要：With worldwide aims to monitor microplastics (MP) in the environment, food and drinking water, there is a growing need for fast, reliable and high-throughput analysis methods. While on the instrumental side, spectroscopic techniques are used widely as they proved suitable for identifying even micron-range plastic particles, there is a gap to fill on the data analysis side. Vibrational spectra of MP are highly complex, and often, large data sets need to be evaluated. Methods range from classical library search to complex artificial intelligence models, each of which has its strengths and weaknesses. This critical review discusses the accuracy, robustness and expenditure of data analysis routines proposed for identification of MP using vibrational spectra. Programs provided by the scientific community dedicated to MP analysis are introduced. Thereby, this review aims to provide guidance for everyone who wants to set up or enhance a data analysis routine for vibrational spectra of MP.(c) 2022 Elsevier B.V. All rights reserved.
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Elsevier
Lopez-Lorente, Angela I.Pena-Pereira, FranciscoPedersen-Bjergaard, StigZuin, Vania G....
10页查看更多>>摘要：The ten principles of GSP are presented with the aim of establishing a road map toward the development of overall greener analytical methodologies. Paramount aspects for greening sample preparation and their interconnections are identified and discussed. These include the use of safe solvents/reagents and materials that are renewable, recycled and reusable, minimizing waste generation and energy demand, and enabling high sample throughput, miniaturization, procedure simplification/automation, and operator's safety. Further, the importance of applying green metrics for assessing the greenness of sample preparation methods is highlighted, next to the contribution of GSP in achieving the broader goal of sustainability. Green sample preparation is sample preparation. It is not a new subdiscipline of sample preparation but a guiding principle that promotes sustainable development through the adoption of environmentally benign sample preparation procedures. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
原文链接:- NSTL
- Elsevier
Wang, JiaZhu, LongjiaoLi, TianshunLi, Xiangyang...
24页查看更多>>摘要：Functional nucleic acids (FNAs) have emerged as superior molecular recognition elements with high binding affinity, specificity, and catalytic activity. Due to multiple functionalities like specific recognition, stimulus responsiveness, sequence programmability, structural tailorability, and ease of modification, FNAs have been integrated into lateral flow assays (LFAs) to construct simple and sustainable paper based chromatographic biosensors for rapid, antibody-free, cost-effective, and user-friendly target detection. This review presented a systematic, comprehensive summary of functional nucleic acid-based lateral flow assays (FNA-LFAs). First, the screening, characterization, and tailoring of FNAs to meet the requirements of LFAs were briefly introduced. Second, the multi-functionality of FNAs for developing high-performance LFAs is presented, along with the entire LFA process from sample pretreatment to signal transduction. Finally, the applications of FNA-LFAs in point-of-care testing (POCT) are illustrated along with future research perspectives, aiming to provide a valuable reference for researchers in the field of FNA sensing.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Liu, RuiFeng, Zhi-YuanLi, DonghaoJin, Biao...
16页查看更多>>摘要：Neurotransmitters are biologically active molecules that are crucial for the regulation of normal physi-ological functions in the central and peripheral nervous systems. Therefore, accurate detection of neu-rotransmitters is significant in many applications, such as clinical diagnosis, biological analysis, and pathological research. However, quantitative analysis of neurotransmitters is difficult as they are released dynamically and at very low concentrations (e.g., dopamine is released at concentrations of 0.065-0.326 nM) [64]. In this regard, microelectrodes have attracted considerable attention as electrochemical biosensors owing to their excellent sensitivity, high response rate, and high stability. Among the various electrode materials, carbon has shown high potential owing to its high electrical conductivity and low cost. Moreover, carbon-based microelectrodes can be used in real time in vivo to detect neurotrans-mitters. This review summarizes the various carbon-based microelectrodes developed as biosensors and discusses their sensitivity and limit of detection with regard to neurotransmitters. The review provides insight into the development of carbon-based microelectrodes as biosensors to detect neurotransmitters and the future prospects and commercialization capabilities of such devices.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Sala, AlexandreBrisset, HuguesMargaillan, AndreMullot, Jean-Ulrich...
17页查看更多>>摘要：Quantification of trace levels of metal ions is an important issue in terms of health and environment safety. Ion-imprinted polymers (IIPs) are synthetic materials that present excellent selectivity properties. Therefore, when combined with electrochemical sensors, proven to be low-cost and time-efficient, they can act as remarkably selective receptors. The development of these type of electrochemical sensors has seen an increase in attention in the past decade. The aim of this review is to give the current state of the art in the conception and performances of IIP-based electrochemical sensors (IIPECS). It is illustrated by many examples of applications that prove the high potential of IIPECS to quantify metal ions in a wide range of real samples with high sensitivity and selectivity.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Liang, Ting-TingQin, XiaolingXiang, YuanhangTang, Yujin...
14页查看更多>>摘要：Extracellular vesicles (EVs) are emerging as biomarkers by inheriting biomolecular information from their parental cells. They are highly heterogeneous and can reflect the status of diseases, like cancer. These features intrigue intense interest in EVs-oriented bioanalysis with different detection technologies and bioprobes for noninvasive diagnosis. In this review, we summarize the recent advances in nucleic acids-mediated EVs detection approaches based on various electric signaling, such as electrochemistry, field effect transistor (FET), and biomimetic nanochannel, with a focus on electrochemical strategies. We also highlight the contribution of nucleic acids, particularly DNA self-assembly structures in analyzing EVs from extravesicular to intravesicular with high sensitivity through interface regulation. Further, we discuss the challenges of electric EVs detection strategies in clinical application and provide insights into future perspectives in this field.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Lu, ChangZhou, ShuaishuaiGao, FeiLin, Jianhan...
14页查看更多>>摘要：The morphology of nanomaterials plays a critical role in their physicochemical properties, and a precise modulation of the morphology is vitally important. As a promising capping agent, DNA has been used for directing the transition of metal nanoparticle seeds into different morphologies with enhanced prop-erties, which has received extensive attention in biosensing. This paper reviews the research on DNA-mediated growth of noble metal nanomaterials for biosensing applications. We present the formation mechanism, which mainly includes DNA binding to metal nanoparticles, metal ion reduction, and regrowth on nanoparticle seeds. We then systematically summarize various metal nanomaterials with different morphologies mediated by physisorbed and thiolated DNA, and introduce the stability, recognition, surface-enhanced Raman scattering, surface plasmon resonance, catalytic, and biocompat-ibility properties of these nanomaterials and their biosensing applications. This review provides a ground for further research on the DNA-mediated growth of nanomaterials and their application to biosensing and beyond. (c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Zhu, Jun-JieWu, RongFeng, ZheJiang, Liping...
14页查看更多>>摘要：Quantum dots (QDs), with confined size on the nanoscale (1-10 nm), are usually made of II-VI B group or III-V A group elements or their alloyed semiconductor materials. QDs are endowed with prominent electrochemical and photophysical properties, which makes QD-based assays powerful probes for electrochemical bioanalysis. Both excellent signal enhancement and functionalization have been explored and further developed. In this review, we start by briefly introducing the electrochemical and photophysical characteristics of QDs. Next, the mechanism of QDs for electrochemical cell analysis is systematically stated and critically reviewed from the three aspects of the main components, mecha-nism, and principle of QD-based electrochemistry (EC), electrochemiluminescence (ECL) and photo-electrochemistry (PEC) cytosensing, individually. The main context will focus on the critical comparison of advantages and disadvantages, similarities, and differences among EC, ECL and PEC. In addition, we summarize selected articles from 2017 to 2021 on QD-based electrochemical cytosensors and discuss the different detection abilities of specific targets, including quantitative cell detection, cell surface bio-markers, cell metabolism, and single-cell analysis.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Ye, DongyangLi, XiaoweiShen, JianzhongXia, Xi...
14页查看更多>>摘要：Microbial metabolomics focuses on the analysis of intracellular or extracellular primary metabolites, signaling molecules, hormones, and secondary metabolites, and it is an important field in systems biology. The progress in microbial metabolomics has been slow primarily due to the complexity and diversity of microbial metabolites, which are usually difficult to identify. However, with the rapid development of novel analytical techniques, microbial metabolomics has attracted increasing attention because it not only elucidates the network of various metabolic pathways, but also expounds the mechanisms underlying the interactions between microbes and hosts. This review discusses the current state of the art novel technologies, including instrument platforms, sample preparation methods, and data handling and analysis tools and resources for microbial metabolomics. In addition, we also describe the recent applications and challenges associated with microbial metabolomics.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Krishnamurthy, AparnaAnand, Robbyn K. K.
19页查看更多>>摘要：Microscale extraction offers several distinct advantages over bench-scale processes including increases in sample throughput, specificity, and efficiency. These attributes can be harnessed to improve the efficacy of assays, amplify analyte signals in sensors or purify samples. Recently, electrokinetic microextraction techniques have garnered increased attention owing to advantages such as control over mass transport, ease of actuation, and portability, which allow them to be readily incorporated into microscale and pointof-care devices. Ion concentration polarization (ICP) continuously creates an electric field gradient that can drive electrokinetic focusing. While the majority of articles on ICP have deliberated on analyte preconcentration, very few have ventured the subsequent extraction step - separation into another phase. The overarching aim of this review is to discuss recent developments in microfluidic extraction methods facilitated by ICP and the potential for their further advancement. Fundamental strategies used to achieve ICP-mediated extraction of distinct classes of analytes are discussed. (c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
