Bu, YusiHu, QiBao, TaoXie, Xiaoyu...
16页查看更多>>摘要：Natural products and their derivatives are a rich source for drug discovery. Meanwhile, cell membrane has emerged as an effective tool to screen the active compounds from natural products. Recently, the cell membrane-coated technology has attracted increasing attention due to its unique biointerfacing abilities. This review focuses on the recent technological advances (2017-2021) in developing cell membrane coated technologies as potential platforms for drug discovery from natural products. Furthermore, the molecular basis of membrane proteins and membrane lipids as drug targets are described. Particularly, four major strategies including cell membrane chromatography and cell membrane-coated magnetic materials are highlighted. Additionally, different functionalization methods for a better screening effect are discussed. Finally, the prospective in terms of subcellular membrane coating, novel coupled technology and stability improvement for high performance exploration are proposed. This review will provide deeper insights into the advanced design and application research of cell membrane-coated technology for drug discovery. (c) 2022 Elsevier B.V. All rights reserved.
原文链接:
NSTL
Elsevier
Hidalgo-Serrano, MiriamBorrull, FrancescMarce, Rosa M.Pocurull, Eva...
14页查看更多>>摘要：Phthalate esters are high production volume chemicals and are widely used as additives in the plastics industry. Since they are not chemically bound to the plastics, they can easily leach into the environment. They can also be transformed into phthalate monoesters via degradation or metabolization. As numerous studies have reported the negative effects of phthalate diesters and monoesters on marine biota, these contaminants are an emerging concern.In this article we review the most important analytical methods for determining phthalate esters in seawater, marine sediments and biota. The QuEChERS method and ultrasound-assisted extraction are the most common techniques for extracting solid samples, while solid-phase extraction is the most common technique for seawater samples. We also describe the occurrence and distribution of phthalate esters in the marine environment. Bis(2-ethylhexyl) phthalate, di-n-butyl phthalate and diisobutyl phthalate, as well as their metabolites, are the main compounds detected in the reviewed matrices.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
He, LuFeng, YantingFeng, YaqiangQian, Cheng...
27页查看更多>>摘要：Catalytic hairpin assembly (CHA) with advantages of high efficiency, flexible design, and mild reaction condition is considered a promising molecular amplifier. Modified working principle of CHAs has been coupled with multiples signal generation and signal transductions to develop the diversified fluorescent biosensors. Emerging signal amplification techniques were introduced into CHA to meet the requirement of rapid, sensitive, accurate, and specific point-of-care testing (POCT) in vitro. Moreover, others advanced techniques were integrated with CHA to improve the delivery efficiency, enhance the ability, and accelerate reaction speed for in vivo analysis. Thus, the CHA-based fluorescent biosensor has been applied on varying targets, including nucleic acids, metal ions, small molecules, proteins, enzymes, exosomes, and cells. Herein, the review systematically summarized the design principle, evolution, and application of the biosensors, and then discussed the challenges in depth. The aim was to highlight the importance of developing advanced CHA-based biosensors and promoting their practical application.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Zhang, MengWang, NingningLi, Zhaohui
27页查看更多>>摘要：Lanthanide-doped upconversion nanoparticles (UCNPs) have recently aroused enormous attention, due to large anti-Stokes shifts, weak autofluorescence, less photodamage and photobleaching, as well as deeper tissue penetration. Owing to their advantageous photophysical properties, UCNPs have been widely applied in analytical and biomedical research fields, such as sensing, imaging, and therapy. This review mainly focuses on recent advances in chromophore-assembled upconversion nanoprobes (UC nanoprobes) for chemo/biosensing. We first demonstrate the principle for constructing UC nanoprobes, and then give a detailed summary of chromophore loading strategies. Furthermore, recent achievements on the construction and application of chromophore-loaded UC nanoprobes are summarized. Also, the current challenges and future prospects of UC nanoprobes are discussed as a conclusion. We expect this review will offer valuable guidance on the selection of chromophores and their loading strategies to further facilitate the fabrication and applications of chromophore-assembled UC nanoprobes.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Acter, ThaminaUddin, NizamCho, EunjiRiches, Eleanor...
13页查看更多>>摘要：To gain insight into the chemical composition and characteristics of petroleum, its characterization and structural identification at the molecular level is essential. To this aim, mass spectrometry techniques, especially ultrahigh-resolution mass spectrometry and its coupling with other complementary tools such as hydrogen-deuterium exchange, tandem mass spectrometry are important analytical methods. In particular, the analytical power of ion mobility (IM) coupled with high-resolution mass spectrometry (IMMS) in structural characterization has expanded its scope from biomolecules to petroleum since 2009, providing improved peak capacities and more accurate structural assignments in petroleum samples. The separation of gas-phase ions in IM devices is based on their size or shape (e.g., collisional cross section), charge, and drift gas. Information on the structure of petroleum ions is then obtained by comparing the theoretical and experimental collision cross-sections obtained using IMMS. Considering the relevance that the construction of a systematic guideline of IMMS for the molecular characterization of petroleum would have in the context of petroleum technology, we describe in this review some instructive examples of the application of IMMS to the analysis of petroleum compounds and petroleum products, along with its future perspective, with the aim of providing a potent guide for petroleum specialists who want a comprehensive and concise overview of the implications of the IMMS technology for petroleum analysis.(c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Kaplitz, Alexander S.Berger, Terry A.Berger, Blair K.Schug, Kevin A....
9页查看更多>>摘要：Separation and purification of complex mixtures are a necessity and a challenge in many industrial fields. Preparative chromatography is a technique used to separate, purify, and isolate the different components found in these complex mixtures. Supercritical fluid chromatography (SFC) is an attractive technique in the industry due to its analysis speed, low analysis cost, green nature, and application space. As such, SFC has been appropriately scaled to match the industry's needs. An examination of preparative SFC is discussed, with this review focusing on the development and application of fraction collection. The various devices used to assist in the separation of the carbon dioxide mobile phase from the analyte and the modifier are described, as well as the techniques to control the fractionation. Applications of fraction collection are also discussed, with two-dimensional chromatography and supercritical fluid extraction coupled with SFC highlighted. (c) 2022 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
