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Elsevier
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Elsevier

0165-9936

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    In vivo solid phase microextraction for bioanalysis

    Queiroz M.E.C.Souza I.D.D.Oliveira I.G.D.Grecco C.F....
    18页
    查看更多>>摘要：? 2022 Elsevier B.V.Solid phase microextraction (SPME) is a rapid, well-established, and solvent-free sample preparation technique. It has usually been hyphenated with GC-MS or LC-MS/MS to separate and to detect enriched analytes. In recent years, ambient ionization techniques have been developed fast. This has allowed MS to be used for direct and straightforward SPME analysis of complex samples, dismissing the need for chromatographic separation. SPME sampling disturbs systems to a minimum—it removes (extracts) only small fractions of analytes. Therefore, in vivo analysis is a special application area where SPME is gaining ground. This review summarizes state-of-the-art in vivo SPME for bioanalysis (in human, rats, fishes, rhesus macaque, frog, and living cattle), including biocompatible SPME coatings, sampling approaches for in vivo SPME (skin, exhaled breath, saliva, blood, muscle, and brain sampling), analytical/detection systems, and calibration methods. This review also discusses in vivo SPME applications (pharmacokinetic studies, exposure, biomarkers, diagnosis, doping control, lipidomics, drug analysis, cosmetic dermatology, bioaccumulation, biomonitoring, environmental pollutants, and therapeutic drug monitoring) and future trends in in vivo SPME bioanalysis.
      原文链接:
    • NSTL
    • Elsevier

    Recent advances of innovative and high-efficiency stationary phases for chromatographic separations

    Wu Y.Luo K.Bai Z.Tang S....
    9页
    查看更多>>摘要：Advances in chromatographic technology depend to a large extent on the development of novel stationary phases with enhanced separation efficiency to meet the ever-growing demands for highly selective and sensitive detection of diverse analytes. This review article specifically highlights the most recent advances of the newly developed efficient chromatographic separation materials in 2020–2021, mainly focusing on their novel synthesis strategies, performance evaluation, as well as their latest applications in hydrophilic interaction chromatography and chiral separation that are the research hotspots and have received the most attention. The purpose of this article is to put the state-of-art of multifunctional stationary phases into perspective, enabling the readers to have a comprehensive overview and insight into their significance in current and future separation technologies.
      原文链接:
    • NSTL
    • Elsevier

    Isothermal nucleic acid amplification for food safety analysis

    Deng R.Cao J.Xia X.Yang H....
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Rapid assays allowing for on-site or in-field testing can enable us to detect food contamination in a timely manner, thus facilitating the insurance of food safety. Isothermal nucleic acid amplification has emerged as a tool for rapid and high-efficiency signal amplification for both nucleic acid and non-nucleic acid targets. In this review, we outline how the features of isothermal amplification techniques have been leveraged for food safety analysis, and present the principles of isothermal amplification techniques. We then introduce isothermal amplification-based approaches for foodborne pathogen and authenticity analysis by detecting nucleic acid markers. Further, the techniques for heavy metal, mycotoxin and antibiotic detection by isothermal amplification combined with functional nucleic acids were reviewed. And particularly, imaging methods enabled by isothermal amplification for in situ analyzing foodborne pathogens are highlighted. Current limitations of these technologies, such as robustness and enzyme preservation, that hinder broad application, are also discussed.
      原文链接:
    • NSTL
    • Elsevier

    Ligand chemistry of gold, silver and copper nanoparticles for visual read-out assay of pesticides: A review

    Mehta V.N.Ghinaiya N.Kailasa S.K.Rohit J.V....
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Metal nanoparticles have garnered a significant interest in various fields of science because of their remarkable optical properties, and they have shown a great impact in improving the sensitivity of UV–Visible spectrometry, just like as expensive analytical instruments. Modifications of metal nanoparticles (Au, Ag and Cu) with specific ligands have shown great potentiality to establish miniaturized colorimetric assay of wide variety molecules, offering the quantification of trace level target analytes via the color changes, which could be noticed with naked-eye. The interface between the ligand chemistry of metal nanoparticles and trace level pesticides leads to the specific covalent and non-covalent interactions, thereby causing a significant color change in the metal nanoparticles via the aggregation of metal nanoparticles induced by pesticides. In this review, the role of ligand chemistry on the surfaces of metal nanoparticles (Au, Ag and Cu) for colorimetric detection of various pesticides is summarized. This review briefly illustrates the aggregation mechanisms involving in the colorimetric detection of pesticides using functionalized metal nanoparticles as colorimetric sensors. Further, this review also summarizes the used ligands on the surfaces of metal nanoparticles (Au, Ag and Cu) for visual readouts of various pesticides at minimal volumes of samples. Finally, we outline the challenges and future perspectives of ligand chemistry on metal nanoparticles for colorimetric assays of pesticides from various samples.
      原文链接:
    • NSTL
    • Elsevier

    Advances in metal-organic frameworks-based gas sensors for hazardous substances

    Huang X.Gong Z.Lv Y.
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Harmful and toxic gas sensing techniques are of vital importance for ecological environment. Abundant physical and chemical properties of metal-organic frameworks (MOFs) have been discovered gradually, such as luminescence, catalysis, and electrical conductivity, which make MOFs evolve into a kind of powerful sensing materials. Although many reported MOF-based sensors have been well reviewed, a comprehensive summary focused on the extremely toxic and harmful gas/vapor sensors is missing. In this review, from a different perspective, the major advances and applications of MOF-based sensors towards the very harmful and toxic analytes in the gas or vapor phase are reviewed, and the sensing mechanisms are also highlighted in detail. Finally, the critical challenges and prospects in this field are discussed from a macro point of view. It is expected that this review could offer a guidance of current state-of-art state on MOF-based hazardous gas/vapor sensors, and accelerates the further practical applications.
      原文链接:
    • NSTL
    • Elsevier

    Functionalized nanomaterials in separation and analysis of extracellular vesicles and their contents

    Zhang N.Sun N.Deng C.Chen H....
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Extracellular vesicles are closely related to most of physiological and pathological events in organisms, and can be applied as therapeutic targets or disease indicators. Whereas the complex physiological environment where they face makes it difficult to conduct direct analysis. In order to solve this problem, many efforts have been made during the past years, among which nanomaterials attract much attention because of their outstanding flexibility in preparation and operation. This article reviews the recent progress of nanomaterials in the separation and analysis of extracellular vesicles, focusing on the applications of nanomaterials in the enrichment of extracellular vesicles and their contents. Also, some tips for exosome separation and analysis are briefly suggested.
      原文链接:
    • NSTL
    • Elsevier

    Deployment of functional DNA-based biosensors for environmental water analysis

    Zhao Y.Yavari K.Wang Y.Liu J....
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Various functional DNA molecules have been used for the detection of environmental contaminants in water, but their practical applications have been limited. To address this gap, this review highlights the efforts to develop field-deployable water quality biosensors. The biosensor devices include microfluidic, lateral flow and paper-based devices, and other novel ideas such as the conversion of glucometers for the detection of environmental analytes. In addition, we also review DNA-functionalized hydrogels and their use in diffusive gradients in thin films (DGT) devices. We classify the sensors into one-step and two-step assays and discuss their practical implications. While the review is focused on works reported in the last five years, some classic early works are cited as well. Overall, most of the existing work only tested spiked water samples. Future work needs to shift to real environmental samples and the comparison of DNA-based sensors to standard analytical methods.
      原文链接:
    • NSTL
    • Elsevier

    Toward smart diagnosis of pandemic infectious diseases using wastewater-based epidemiology

    Mahmoudi T.Naghdi T.Golmohammadi H.Morales-Narvaez E....
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.COVID-19 outbreak revealed fundamental weaknesses of current diagnostic systems, particularly in prediction and subsequently prevention of pandemic infectious diseases (PIDs). Among PIDs detection methods, wastewater-based epidemiology (WBE) has been demonstrated to be a favorable mean for estimation of community-wide health. Besides, by going beyond purely sensing usages of WBE, it can be efficiently exploited in Healthcare 4.0/5.0 for surveillance, monitoring, control, and above all prediction and prevention, thereby, resulting in smart sensing and management of potential outbreaks/epidemics/pandemics. Herein, an overview of WBE sensors for PIDs is presented. The philosophy behind the smart diagnosis of PIDs using WBE with the help of digital technologies is then discussed, as well as their characteristics to be met. Analytical techniques that are pushing the frontiers of smart sensing and have a high potential to be used in the smart diagnosis of PIDs via WBE are surveyed. In this context, we underscore key challenges ahead and provide recommendations for implementing and moving faster toward smart diagnostics.
      原文链接:
    • NSTL
    • Elsevier

    Recent advances and application of carbon nitride framework materials in sample preparation

    Kang J.-Y.Shi Y.-P.
    5页
    查看更多>>摘要：? 2022 Elsevier B.V.Sample preparation is an indispensable process in sample analysis. Solid-phase extraction technology can isolate and enrich target analytes from complex matrices, eliminating potential interferences and improving method parameters such as sensitivity, accuracy and precision. Carbon nitride framework materials (CNFs) consisted with tri-s-triazine units have attracted increasing attention as solid-phase extractants in analytical fields. The affluent in-built N-rich functional groups and large delocalized large π bonds structure endow CNFs excellent extraction capacity and selectivity based on chemical complexation, ions exchange, strong π-π conjugation, hydrogen bond interaction and electrostatic interaction. In this review, we focus on the advancements of CNFs materials in sample preparation. The preparation methods of CNFs with different chemical structures are introduced. Besides, modification strategies for improving adsorption efficiency and selectivity of CNFs are summarized. Finally, the applications of CNFs in inorganic and organic extraction and analysis (pesticide residues, foods and environment pollution analysis) are reviewed.
      原文链接:
    • NSTL
    • Elsevier

    Trends in pharmaceutical analysis and quality control by modern Raman spectroscopic techniques

    Silge A.Popp J.Cialla-May D.Muller-Botticher L....
    5页
    查看更多>>摘要：? 2022 The Author(s)The application of Raman spectroscopic methods in life science applications has entered a new era due to advances in instrumentation, miniaturization and, most importantly, increased interdisciplinary dialogue between spectroscopists and end users such as clinicians or pharmacists. Advances in laser sampling technologies, optical instruments and data analysis provide new possibilities for optical sensing and chemical imaging. Raman based technologies are being driven by these new developments, opening new applications for advanced pharmaceutical development and manufacturing. Due to, non-destructive and label free quality testing of drug formulations, Raman sensing is of particular interest for process-related aspects in bioprocessing. The trend to personalized medicine, particularly for pediatric and geriatric applications increased the number of prescriptions of individually tailored medicines manufactured in public pharmacies. This article discusses trends and updates of Raman based analytics and how Raman spectroscopic information can create value for modern pharmaceutical applications and processes. The first section reviews Raman modalities that have great potential for on-site applications in the pharmaceutical industry as well as in research and development. The second section provides an overview of innovative Raman spectroscopic devices and the many possibilities in terms of analytical capabilities and sample properties. Photonic data science has been an important driver for Raman based technologies breakthroughs in the last decade and help to standardize Raman spectral analysis, which is discussed in the third section. In the last section we discuss how to translate Raman based innovations into user-friendly on-site applications.
      原文链接:
    • NSTL
    • Elsevier