查看更多>>摘要:The investment of nearly 2 decades of clinical investigation into cardiac cell therapy has yet to change cardiovascular practice。 Recent insights into the mechanism of cardiac regeneration help explain these results and provide important context inwhich we can develop next-generation therapies。 Non-contractile cells such as bone marrow or adult heart derivatives neither engraft long-term nor induce new muscle formation。 Correspondingly, these cells offer little functional benefit to infarct patients。 Incontrast, preclinical data indicate that transplantation of bona fide cardiomyocytes derived from pluripotent stem cells induces direct remuscularization。 This new myocardium beats synchronously with the host heart and induces substantial contractile benefits in macaque monkeys, suggesting that regeneration of contractile myocardium is required to fully recover function。 Through a review of the preclinical and clinical trials of cardiac cell therapy, distinguishing the primary mechanism of benefit as either contractile or non-contractile helps appreciate the barriers to cardiac repair and establishes a rational path to optimizing therapeutic benefit。
查看更多>>摘要:Background: The safety of discontinuing oral anticoagulant (OAC) after ablation for atrial fibrillation (AF) in Japanese patients has not been clarified。
查看更多>>摘要:Background: Atrial fibrillation (AF), which contributes to an increased risk of stroke, frequently remains undetected, suggesting an unmet need for easier and more reliable AF screening。 The reports on screening AF using an Omron blood pressure (BP) monitor with an irregular heartbeat (IHB) detector show inconsistent results, so the aim of this study was to develop a novel algorithm to accurately diagnose AF with 3 BP measurements using an Omron automated BP monitor with IHB detector。
查看更多>>摘要:Background: Guideline-adherent antithrombotic treatment (ATT) reduces the risk of stroke and death in patients with atrial fibrillation (AF)。 However, the effect of ATT adherence among different ethnicities remains uncertain。 We compared the prognosis of AF patients in Japan and the UK according to guideline adherence status。
Ouyang, FeifanVogler, JuliaEitel, CharlotteTilz, Roland Richard...
9页
查看更多>>摘要:Background: Radiofrequency (RF)-based pulmonary vein isolation (PVI) results in a favorable clinical outcome, although its complexity demands a long learning curve。 Balloon-based systems have been developed to possibly solve these limitations。 The 2nd-generation laser balloon (LB2) offers optimized features for improved tissue contact and visibility。 We determined the safety, efficacy and learning curve of the LB2 for PVI。
查看更多>>摘要:Background: Healed plaques are identified as a layered pattern with optical coherence tomography (OCT) imaging, but the exact relationship between healed plaques and the development of significant coronary stenosis in stable angina pectoris (SAP) is not fully understood。