查看更多>>摘要：? 2021High resolution mobility analysis of an electrosprayed sample of the ΦX174 bacteriophage reveals an exceptionally narrow size distribution (relative diameter full width at half maximum below 0.7%) centered at a mean mobility diameter dp = 28.9 nm. These icosahedral particles are commercially available in solution at concentrations in excess of 109/mL. Here they are simply dialyzed into 10 mM aqueous ammonium acetate, before being atomized in a bipolar electrospray.
查看更多>>摘要：? 2022 Elsevier LtdThe application of supercritical fluids in particle formation processes has attracted great attention due to numerous advantages over classical size reduction technologies. These classical approaches can be subdivided into top-down and bottom-up technologies. Typical top-down methods are milling, grinding and crushing, thereby one starts with a (large) bulk material and obtains the sub-micron particles due to size reduction. On the other hand, by bottom-up techniques, one starts with atoms or molecules which growth is caused by, e.g. co-precipitation or crystallization. In some cases, the disadvantages of the classical top-down and bottom-up approaches which are, among others, the control of size, size distribution, composition, and morphology, can be overcome by the utilization of supercritical fluids, which are characterized by liquid-like densities and gas-like viscosities and diffusion coefficients. The present article gives a survey (that never can pretend to be exhaustive!) of knowledge published in the period from end of the eighties until today about the micronization of organic compounds based on supercritical fluid induced phase transition processes. Here, the focus is on rapid expansion of supercritical solution (RESS). In this process organic solids are dissolved in the supercritical fluid, typically CO2, and are precipitated caused by a pressure drop.
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