查看更多>>摘要：Chimeric antigen receptor (CAR) T cell therapy has recently shown unprecedented clinical efficacy for cancer treatment, particularly of hematological malignancies. However, the complex manufacturing processes that involve ex vivo genetic modification of autologous T cells limits its therapeutic application. CAR T cells generated in vivo provide a valid alternative immunotherapy, “off-the-shelf”, for cancer treatment. This approach requires carriers for the delivery of CAR-encoding constructs, which are plasmid DNA or messenger RNA, to T cells for CAR expression to help eradicate the tumor. As such, there are a growing number of studies reporting gene delivery systems for in vivo CAR T cell therapy based on viral vectors and polymeric nanoparticles. Hyaluronic acid (HA) is a natural biopolymer that can serve for gene delivery, because of its inherent properties of cell recognition and internalization, as well as its biodegradability, biocompatibility, and presence of functional groups for the chemical conjugation of targeting ligands. In this review, the potential of HA in the delivery of CAR constructs is discussed on the basis of previous experience of HA-based nanoparticles for gene therapy. Furthermore, current studies on CAR carriers for in vivo-generated CAR T cells are included, giving an idea of a rational design of HA-based systems for the more efficient delivery of CAR to circulating T cells.
查看更多>>摘要：Hydrogen prepared by electrocatalytic decomposition of water (“green hydrogen”) has the advantages of high energy density and being clean and pollution-free, which is an important energy carrier to face the problems of the energy crisis and environmental pollution. However, the most used commercial electrocatalysts are based on expensive and scarce precious metals and their alloy materials, which seriously restricts the large-scale industrial application of hydrogen energy. The development of efficient non-precious metal electrocatalysts is the key to achieving the sustainable development of the hydrogen energy industry. Transition metal sulfides (TMS) have become popular non-precious metal electrocatalysts with great application potential due to their large specific surface area, unique electronic structure, and rich regulatory strategies. To further improve their catalytic activities for practical application, many methods have been tried in recent years, including control of morphology and crystal plane, metal/nonmetal doping, vacancy engineering, building of self-supporting electrocatalysts, interface engineering, etc. In this review, we introduce firstly the common types of TMS and their preparation. Additionally, we summarize the recent developments of the many different strategies mentioned above for efficient water electrolysis applications. Furthermore, the rationales behind their enhanced electrochemical performances are discussed. Lastly, the challenges and future perspectives are briefly discussed for TMS-based water dissociation catalysts.
Yang ChangpingWu XiaohuiLiu JianbingDing Baoquan...
9页
查看更多>>摘要：Based on complementary base pairing, nucleic acid molecules have acted as engineerable building blocks to prepare versatile nanostructures with unique shapes and sizes. Benefiting from excellent programmability and biocompatibility, rationally designed nucleic acid nanostructures have been widely employed in biomedical applications. With the development of the chemical biology of nucleic acids, various stimuli-responsive nucleic acid nanostructures have been constructed by tailored chemical modification with multifunctional components. In this minireview, we summarize the representative and latest research about the employment of stimuli-responsive nucleic acid nanostructures for drug delivery in response to endogenous and exogenous stimuli (redox gradient, pH, nuclease, biomacromolecule, and light). We also discuss the broad prospects and remaining challenges of nucleic acid nanotechnology in biomedical applications.
Aizudin MarliyanaAlias Nur HashimahNg Yun Xin AngelMahmod Fadzuli Muhammad Haikal...
16页
查看更多>>摘要：Graphene-based nanomaterials (GBnMs) are currently regarded as a critical building block for the fabrication of membranes for water purification due to their advantageous properties such as easy surface modification of functional groups, adjustable interlayer pore channels for solvent transportation, robust mechanical properties, and superior photothermal capabilities. By combining graphene derivatives with other emerging materials, heteroatom doping and rational design of a three-dimensional network can enhance water transportation and evaporation rates through channels of GBnM laminates and such layered structures have been applied in various water purification technologies. Herein, this mini-review summarizes recent progress in the synthesis of GBnMs and their applications in water treatment technologies, specifically, nanofiltration (NF) and solar desalination (SD). Finally, personal perspectives on the challenges and future directions of this promising nanomaterial are also provided.
查看更多>>摘要：Stimuli-responsive hydrogels with self-strengthening properties are promising for the use of autonomous growth and adaptation systems to the surrounding environments by mimicking biological materials. However, conventional stimuli-responsive hydrogels require structural destruction to initiate mechanochemical reactions to grow new polymeric networks and strengthen themselves. Here we report continuous self-strengthening of a nanocomposite hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) and nanoclay (NC) by using external stimuli such as heat and ionic strength. The internal structures of the NC-PNIPAM hydrogel are rearranged through the swelling–deswelling cycles or immersing in a salt solution, thus its mechanical properties are significantly improved. The effects of concentration of NC in hydrogels, number of swelling–deswelling cycles, and presence of salt in the surrounding environment on the mechanical properties of hydrogels are characterized by nanoindentation and tensile tests. The self-strengthening mechanical performance of the hydrogels is demonstrated by the loading ability. This work may offer promise for applications such as artificial muscles and soft robotics.
查看更多>>摘要：Non-covalent bonds are fundamental for designing self-assembled organic structures with potentially high responsiveness to mechanical, light, and thermal stimuli. The weak intermolecular interaction allows triggering charge-transport, energy-conversion, enzymatic, and catalytic activity, to name a few. Here, we discuss the synergistic action that multiple highly-directional and purely electrostatic bonds have in assembling one molecular specie, namely 4,7-dibromobenzo[c]-1,2,5-thiadiazole (2Br-BTD), in two different patterns on the Au(111) surface. We find, using scanning tunneling microscopy (STM) and density functional theory (DFT), that multiple secondary-interactions strengthen the electrostatic attraction between the pnicogen and chalcogen atoms forming [S–N]2 heterocycles, the building block of the two networks. Among these interactions, there are halogen–halogen bonds that form characteristic supra-molecular synthons of 3, 4, or 6 molecules. However, not all these nodal structures contribute to the cohesion of the system. In such cases, other secondary bonds involving hydrogen or nitrogen compensate for the eventual deficiency.
查看更多>>摘要：CsPbBr3 perovskite quantum dots (QDs) show great potential in various applications due to their size-dependent and excellent optoelectronic properties. However, it is still challenging to synthesize size-tunable CsPbBr3 QDs with purple emission. Herein, CsPbBr3 nanospheres (NS) with purple emission (432 nm) and wavelength-tunable photoluminescence were synthesized using a two-step recrystallization method for the first time. A nanocube (NC) strategy resulting from CsPbBr3 nanosphere self-assembly via polar solvent-induced surface ligand mismatch was proposed. The self-assembly process endows the QDs with wavelength-tunable photoluminescence ranging from 432 to 518 nm. The significant reduction in defects during self-assembly was confirmed by transient optical spectroscopy measurements, photoluminescence quantum yields (PLQY), and the disappearance of tail bands in the long-wavelength region of the photoluminescence (PL) spectrum. This theory demonstrated that the decrease in high defect surfaces and increase in specific surface area were the reasons for the decline in defects. Most importantly, these QDs could be used for the active jamming of optical imaging systems based on charged-coupled devices (CCDs), including laser imaging radar and low light level (LLL) night vision systems. QDs significantly increase the mean square error (MSE) of the image, while the detection rate of the target by the artificial intelligence algorithm decreased by 95.17%. The wide wavelength tunable emission caused by structural changes makes it arduous for silicon-based detectors to avoid the interference of QDs by adding filters or by other means.
NSTL
Royal Soc Chemistry