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    Ulster University Reports Findings in Type 2 Diabetes (Exploring metformin monotherapy response in Type-2 diabetes: Computational insights through clinical, genomic, and proteomic markers using machine learning algorithms)

    20-21页
    查看更多>>摘要:New research on Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes is the subject of a report. According to news reporting from Londonderry, United Kingdom, by NewsRx journalists, research stated, "In 2016, the UK had 4.5 million people with diabetes, predominantly Type-2 Diabetes Mellitus (T2DM). The NHS allocates £10 billion (9% of its budget) to manage diabetes." The news correspondents obtained a quote from the research from Ulster University, "Metformin is the primary treatment for T2DM, but 35% of patients don't benefit from it, leading to complications. This study aims to delve into metformin's efficacy using clinical, genomic, and proteomic data to uncover new biomarkers and build a Machine Learning predictor for early metformin response detection. Here we report analysis from a T2DM dataset of individuals prescribed metformin monotherapy from the Diastrat cohort recruited at the Altnagelvin Area Hospital, Northern Ireland. In the clinical data analysis, comparing responders (those achieving HbA1c 48 mmol/mol) to non-responders (with HbA1c >48 mmol/mol), we identified that creatinine levels and bodyweight were more negatively correlated with response than nonresponse. In genomic analysis, we identified statistically significant (p-value <0.05) variants rs6551649 (LPHN3), rs6551654 (LPHN3), rs4495065 (LPHN3) and rs7940817 (TRPC6) which appear to differentiate the responders and non-responders. In proteomic analysis, we identified 15 statistically significant (pvalue <0.05, q-value <0.05) proteomic markers that differentiate controls, responders, non-responders and treatment groups, out of which the most significant were HAOX1, CCL17 and PAI that had fold change 2. A machine learning model was build; the best model predicted non-responders with 83% classification accuracy."

    New Findings Reported from Polish Academy of Sciences Describe Advances in Machine Learning (The Application of Machine Learning Methods To the Prediction of Novel Ligands for Rory/roryt Receptors)

    21-22页
    查看更多>>摘要:Investigators publish new report on Machine Learning. According to news reporting originating in Lodz, Poland, by NewsRx journalists, research stated, "In this work, we developed and applied a computational procedure for creating and validating predictive models capable of estimating the biological activity of ligands. The combination of modern machine learning methods, experimental data, and the appropriate setup of molecular descriptors led to a set of well-performing models." Financial support for this research came from Narodowe Centrum Nauki. The news reporters obtained a quote from the research from the Polish Academy of Sciences, "We thoroughly inspected both the methodological space and various possibilities for creating a chemical feature space. The resulting models were applied to the virtual screening of the ZINC20 database to identify new, biologically active ligands of RORy receptors, which are a subfamily of nuclear receptors. Based on the known ligands of RORy, we selected candidates and calculate their predicted activities with the bestperforming models. We chose two candidates that were experimentally verified." According to the news reporters, the research concluded: "One of these candidates was confirmed to induce the biological activity of the RORy receptors, which we consider proof of the efficacy of the proposed methodology."

    Studies from Southwestern University of Finance and Economics Further Understanding of Artificial Intelligence (Facilitation or Hindrance: the Contingent Effect of Organizational Artificial Intelligence Adoption On Proactive Career Behavior)

    22-23页
    查看更多>>摘要:Fresh data on Artificial Intelligence are presented in a new report. According to news originating from Chengdu, People's Republic of China, by NewsRx correspondents, research stated, "The advent of Artificial intelligence (AI) technology is catalyzing significant transformations in human work dynamics. Nonetheless, there exists no unanimous consensus among researchers regarding whether organizational AI adoption has a favorable or unfavorable impact on employees' career development." Funders for this research include National Natural Science Foundation of China (NSFC), MOE (Ministry of Education in China) Project of Humanities and Social Sciences, China, Fundamental Research Funds for the Central Universities. Our news journalists obtained a quote from the research from the Southwestern University of Finance and Economics, "Building upon social cognitive theory, we explores the underlying mechanism through which organizational AI adoption in-fluences employees' proactive career behavior. A three-wave timelagged survey involving 348 employees from three hotels and five advanced manufacturing enterprises in Chengdu, China, was conducted. The findings revealed that organizational AI adoption led to a reduction in employees' self-perceived employability. The prominence of an employee's future work self-salience was found to be a determining factor in how their self-perceived employability influenced proactive career behaviors. Specifically, this impact manifested negative for employees exhibiting high levels of future work self-salience, while it appears positive for those with low levels. Finally, this study confirmed the moderating role of future work self-salience in the indirect impact of organizational AI adoption on proactive career behavior through self-perceived employability."

    Findings from Department of Computer Applications Broaden Understanding of Machine Learning (Machine Learning for Enhancing Transportation Security: a Comprehensive Analysis of Electric and Flying Vehicle Systems)

    23-24页
    查看更多>>摘要:New research on Machine Learning is the subject of a report. According to news originating from Punjab, India, by NewsRx correspondents, research stated, "This paper delves into the transformative role of machine learning (ML) techniques in revolutionizing the security of electric and flying vehicles (EnFVs). By exploring key domains such as predictive maintenance, cyberattack detection, and intelligent decisionmaking, the study uncovers pivotal insights that will shape the future of this technology.From a theoretical perspective, ML emerges as a cornerstone for fortifying EnFV safety, offering real-time threat detection, predictive maintenance capabilities, and enhanced anomaly detection." Financial support for this research came from Deanship of Scientific Research at King Khalid University. Our news journalists obtained a quote from the research from the Department of Computer Applications, "In practical terms, MLbased solutions are envisioned as instrumental in preventing cyberattacks, reducing downtime, and improving overall safety.The research contributions of this study encompass a comprehensive overview of ML applications in EnFV security, identification of challenges, and paving the way for future research directions. While acknowledging research limitations, particularly the need for realworld implementation, the study emphasizes the crucial yet underexplored ethical considerations in ML for EnFV security. Future research suggestions focus on Explainable AI techniques, real-time ML algorithms for resource-constrained environments, and privacy-preserving ML techniques, aiming for a transparent, efficient, and privacy-aware integration of ML in EnFV security."

    New Machine Learning Study Results Reported from School of Civil Engineering (Machine Learning and Statistical Test-Based Culvert Condition Impact Factor Analysis)

    24-24页
    查看更多>>摘要:Fresh data on artificial intelligence are presented in a new report. According to news originating from the School of Civil Engineering by NewsRx editors, the research stated, "For managers of road infrastructure, culvert deterioration is a major concern since culvert failures can cause serious risks to the traveling public." Funders for this research include Key Area Dedicated Project of Guangdong General Universities And Colleges. The news reporters obtained a quote from the research from School of Civil Engineering: "The efficiency of the cost- and labor-intensive culvert inspection and maintenance process can be improved by properly identifying the key impact factors on culvert condition deterioration. Although the use of machine learning (ML) techniques to predict culvert conditions has been proven to be a promising tool for enhancing culvert management and enabling proactive scheduling of maintenance tasks, the information provided by the developed ML models has been given little attention for further use and analysis. By utilizing the predictor importance results of an evaluated decision tree (DT) culvert condition prediction model and the Mann- Whitney U test, this study provided insights to the identification of the key variables influencing culvert deterioration. According to the findings, five impact factors, including culvert span, pH, age, rise, and cover height, often have significant impact on the condition ratings of culverts made of various materials." According to the news editors, the research concluded: "In addition, such a statistical test-assisted factor identification process offered a way of identifying and enhancing the input variable selection for predictive ML model development."

    University of Toronto Reports Findings in Peripheral Artery Disease (A machine learning algorithm for peripheral artery disease prognosis using biomarker data)

    25-26页
    查看更多>>摘要:New research on Cardiovascular Diseases and Conditions - Peripheral Artery Disease is the subject of a report. According to news reporting out of Toronto, Canada, by NewsRx editors, research stated, "Peripheral artery disease (PAD) biomarkers have been studied in isolation; however, an algorithm that considers a protein panel to inform PAD prognosis may improve predictive accuracy. Biomarker-based prediction models were developed and evaluated using a model development (n = 270) and prospective validation cohort (n = 277)." Our news journalists obtained a quote from the research from the University of Toronto, "Plasma concentrations of 37 proteins were measured at baseline and the patients were followed for 2 years. The primary outcome was 2-year major adverse limb event (MALE; composite of vascular intervention or major amputation). Of the 37 proteins tested, 6 were differentially expressed in patients with vs. without PAD (ADAMTS13, ICAM-1, ANGPTL3, Alpha 1-microglobulin, GDF15, and endostatin). Using 10-fold crossvalidation, we developed a random forest machine learning model that accurately predicts 2-year MALE in a prospective validation cohort of PAD patients using a 6-protein panel (AUROC 0.84)."

    ShanghaiTech University Reports Findings in Artificial Intelligence (Stop moving: MR motion correction as an opportunity for artificial intelligence)

    25-25页
    查看更多>>摘要:New research on Artificial Intelligence is the subject of a report. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "Subject motion is a long-standing problem of magnetic resonance imaging (MRI), which can seriously deteriorate the image quality. Various prospective and retrospective methods have been proposed for MRI motion correction, among which deep learning approaches have achieved state-of-the-art motion correction performance." Our news journalists obtained a quote from the research from ShanghaiTech University, "This survey paper aims to provide a comprehensive review of deep learning-based MRI motion correction methods. Neural networks used for motion artifacts reduction and motion estimation in the image domain or frequency domain are detailed. Furthermore, besides motion-corrected MRI reconstruction, how estimated motion is applied in other downstream tasks is briefly introduced, aiming to strengthen the interaction between different research areas." According to the news editors, the research concluded: "Finally, we identify current limitations and point out future directions of deep learning-based MRI motion correction." This research has been peer-reviewed.

    Reports on Machine Learning Findings from China Iron and Steel Research Institute Group Provide New Insights (Machine-learning Assisted Design of As-cast Nicofecralti Multi-principal Element Alloys With Tensile Yield Strength Over 1.35 Gpa)

    26-27页
    查看更多>>摘要:A new study on Machine Learning is now available. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "As-cast alloys have the advantage of short forming processes, but there is currently a lack of research on systematic design alloys with better mechanical properties. Herein, combining a machine-learning with random forest model algorithm, a high-throughput alloy design framework under multidimensional constraints was used to discover new NiCoFeCrAlTi multi-principal element alloys (MPEAs) for superior tensile properties." Funders for this research include National Natural Science Foundation of China (NSFC), GIMRT Program of the Institute for Materials Research, Tohoku University, Fundamental Research Funds for the Central Universities. The news correspondents obtained a quote from the research from China Iron and Steel Research Institute Group, "The as-cast dual-phase Ni28Fe32Cr25Al10Ti5 alloy with 1386 MPa of tensile yield strength and 1.8% uniform elongation was designed, which is much higher than the best value in the original training dataset. This apparent high strength can be attributed to the phase interfacial strengthening, in which the soft face-centered cubic (FCC) phase precipitated extensively aside the grain boundaries of hard bodycentered cubic (BCC) matrix. The BCC matrix provides high strength and FCC precipitates play role in ductility."

    Investigators from University of Natural Resources and Applied Life Science Report New Data on Machine Learning (Human-in-the-loop Reinforcement Learning: a Survey and Position On Requirements, Challenges, and Opportunities)

    27-28页
    查看更多>>摘要:New research on Machine Learning is the subject of a report. According to news reporting out of Vienna, Austria, by NewsRx editors, research stated, "Artificial intelligence (AI) and especially reinforcement learning (RL) have the potential to enable agents to learn and perform tasks autonomously with superhuman performance. However, we consider RL as fundamentally a Human -in -the -Loop (HITL) paradigm, even when an agent eventually performs its task autonomously." Funders for this research include Austrian Science Fund (FWF), Alberta Machine Intelligence Institute (Amii), Canada CIFAR AI Chair, Amii, Compute Canada, Huawei Technologies, Mitacs, Natural Sciences and Engineering Research Council of Canada (NSERC). Our news journalists obtained a quote from the research from the University of Natural Resources and Applied Life Science, "In cases where the reward function is challenging or impossible to define, HITL approaches are considered particularly advantageous. The application of Reinforcement Learning from Human Feedback (RLHF) in systems such as ChatGPT demonstrates the effectiveness of optimizing for user experience and integrating their feedback into the training loop. In HITL RL, human input is integrated during the agent's learning process, allowing iterative updates and fine-tuning based on human feedback, thus enhancing the agent's performance. Since the human is an essential part of this process, we argue that human -centric approaches are the key to successful RL, a fact that has not been adequately considered in the existing literature. This paper aims to inform readers about current explainability methods in HITL RL. It also shows how the application of explainable AI (xAI) and specific improvements to existing explainability approaches can enable a better human -agent interaction in HITL RL for all types of users, whether for lay people, domain experts, or machine learning specialists. Accounting for the workflow in HITL RL and based on software and machine learning methodologies, this article identifies four phases for human involvement for creating HITL RL systems: (1) Agent Development, (2) Agent Learning, (3) Agent Evaluation, and (4) Agent Deployment. We highlight human involvement, explanation requirements, new challenges, and goals for each phase. We furthermore identify low -risk, high -return opportunities for explainability research in HITL RL and present long-term research goals to advance the field."

    Beijing University of Chinese Medicine Reports Findings in Artificial Intelligence (The global research of artificial intelligence in lung cancer: a 20-year bibliometric analysis)

    28-29页
    查看更多>>摘要:New research on Artificial Intelligence is the subject of a report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Lung cancer (LC) is the second-highest incidence and the first-highest mortality cancer worldwide. Early screening and precise treatment of LC have been the research hotspots in this field." Financial support for this research came from Beijing Municipal Natural Science Foundation. The news correspondents obtained a quote from the research from the Beijing University of Chinese Medicine, "Artificial intelligence (AI) technology has advantages in many aspects of LC and widely used such as LC early diagnosis, LC differential classification, treatment and prognosis prediction. This study aims to analyze and visualize the research history, current status, current hotspots, and development trends of artificial intelligence in the field of lung cancer using bibliometric methods, and predict future research directions and cutting-edge hotspots. A total of 2931 articles published between 2003 and 2023 were included, contributed by 15,848 authors from 92 countries/regions. Among them, China (40%) with 1173 papers,USA (24.80%) with 727 papers and the India(10.2%) with 299 papers have made outstanding contributions in this field, accounting for 75% of the total publications. The primary research institutions were Shanghai Jiaotong University(n=66),Chinese Academy of Sciences (n=63) and Harvard Medical School (n=52).Professor Qian Wei(n=20) from Northeastern University in China were ranked first in the top 10 authors while Armato SG(n=458 citations) was the most co-cited authors. (121 publications; IF 2022,4.7; Q2) was the most published journal. while (3003 citations; IF 2022, 19.7; Q1) was the most co-cited journal. different countries and institutions should further strengthen cooperation between each other. The most common keywords were lung cancer, classification, cancer, machine learning and deep learning. Meanwhile, The most cited papers was Nicolas Coudray et al.2018.NAT MED(1196 Total Citations). Research related to AI in lung cancer has significant application prospects, and the number of scholars dedicated to AI-related research on lung cancer is continually growing. It is foreseeable that non-invasive diagnosis and precise minimally invasive treatment through deep learning and machine learning will remain a central focus in the future."