查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning DailyNews Daily News – Investigators discuss new findings in Machine Learning. According to news reportingoriginating in Wuhan, People’s Rep ublic of China, by NewsRx journalists, research stated, “Misfoldingand aggregat ion of proteins often lead to the development of diseases, and amyloid has gaine dwidespread attention as a biomarker for a variety of diseases. In this study, we developed a fluorescence/fluorescence colorimetric dual-mode sensor array for the detection of amyloid fibrils using severalcommercially available organic s mall molecular dyes and alkaloids, including Thioflavin T, Congo Red,8-anilino- 1-naphthalenesulfonic acid, Safranine T, berberine and coptisine, as the element s.”Financial supporters for this research include Program for HUST Academic Frontie r Youth Team,National Natural Science Foundation of China (NSFC).The news reporters obtained a quote from the research from the Huazhong Universi ty of Scienceand Technology, “Herein, the array could not only use the fluoresc ence intensities change before andafter protein interaction as a pattern recogn ition signal, but also read the Delta R/Delta G/Delta Bvalues of the photos tak en in the UV dark box on a smartphone-based platform, which converted thechroma ticity information into intuitive data. Five studied amyloid fibrils, i.e. insul in, lysozyme, bovineserum albumin, amyloid-8 42 and alpha-synuclein fibrils, we re properly distinguished with data processingassisted by machine learning algo rithms, i.e. linear discriminant analysis, principal component analysis andhier archical cluster analysis. After reducing the number of elements by principal co mponent analysis, asimplified array quantified individual amyloid fibrils at 0. 05-5 mu M and 0.5-10 mu M with fluorescenceand fluorescence colorimetric signal s, respectively, and successfully identified 25 unknown samples withhigh accura cy in diluted human plasma matrix and artificial cerebrospinal fluid.”