查看更多>>摘要:2024 OCT 03 (NewsRx)-By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Prostate Ca ncer is the subject of a report. According to news reporting originating from Na nchong, People's Republic of China, by NewsRx correspondents, research stated, " Prostate cancer (PCa) is a prevalent malignancy among men, primarily originating from the prostate epithelium. It ranks first in global cancer incidence and sec ond in mortality rates, with a rising trend in China." Our news editors obtained a quote from the research from North Sichuan Medical C ollege, "PCa's subtle initial symptoms, such as urinary issues, necessitate diag nostic measures like digital rectal examination, prostate-specific antigen (PSA) testing, and tissue biopsy. Advanced PCa management typically involves a multif aceted approach encompassing surgery, radiation, chemotherapy, and hormonal ther apy. The involvement of aging genes in PCa development and progression, particul arly through the mTOR pathway, has garnered increasing attention. This study aim ed to explore the association between aging genes and biochemical PCa recurrence and construct predictive models. Utilizing public gene expression datasets (GSE 70768, GSE116918, and TCGA), we conducted extensive analyses, including Cox regr ession, functional enrichment, immune cell infiltration estimation, and drug sen sitivity assessments. The constructed risk score model, based on aging-related g enes (ARGs), demonstrated superior predictive capability for PCa prognosis compa red to conventional clinical features. High-risk genes positively correlated wit h risk, while low-risk genes displayed a negative correlation. An ARGs-based ris k score model was developed and validated for predicting prognosis in prostate a denocarcinoma (PRAD) patients. LASSO regression analysis and cross-validation pl ots were employed to select ARGs with prognostic significance. The risk score ou tperformed traditional clinicopathological features in predicting PRAD prognosis , as evidenced by its high AUC (0.787). The model demonstrated good sensitivity and specificity, with AUC values of 0.67, 0.675, 0.696, and 0.696 at 1, 3, 5, an d 8 years, respectively, in the GEO cohort. Similar AUC values were observed in the TCGA cohort at 1, 3, and 5 years (0.67, 0.659, 0.667, and 0.743). The model included 12 genes, with high-risk genes positively correlated with risk and low- risk genes negatively correlated. This study presents a robust ARGs-based risk s core model for predicting biochemical recurrence in PCa patients, highlighting t he potential significance of aging genes in PCa prognosis and offering enhanced predictive accuracy compared to traditional clinical parameters."