查看更多>>摘要：According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from bi orxiv.org: "The stability of proteins at higher temperatures is crucial for its functionali ty that is measured by their melting temperature (Tm). The Tm is the temperature at which 50% of the protein loses its native structure and activi ty. Existing methods for predicting Tm have two major limitations: first, they a re often trained on redundant proteins, and second, they do not allow users to d esign proteins with the desired Tm. To address these limitations, we developed a regression method for predicting the Tm value of proteins using 17,312 non-redu ndant proteins, where no two proteins are more than 40% similar. W e used 80% of the data for training and testing; remaining 20% of the data for validation. Initially, we developed a machine learning model usi ng standard features from protein sequences.
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