查看更多>>摘要:New research on Oncology-Thyroid Can cer is the subject of a report. According to news reporting from Xi'an, People's Republic of China, by NewsRx journalists, research stated, "Anaplastic thyroid carcinoma (ATC) is a highly aggressive and lethal thyroid cancer subtype with a poor prognosis. Recent advancements in machine learning (ML) have the potential to improve survival predictions." The news correspondents obtained a quote from the research from Xi'an Jiaotong U niversity, "This study aimed to develop and validate ML models using the SEER da tabase to predict 3-month, 6-month, and 12-month (overall survival) OS in ATC pa tients. Clinical and demographic data for patients with ATC from the SEER databa se (2004-2015) were utilized. Five ML algorithms-AdaBoost, support vector machin es, gradient boosting classifiers, random forests, and naive Bayes-were evaluate d. The data were split into training and testing sets (7:3 ratio), and the model s were tuned using fivefold cross-validation. Model performance was assessed usi ng the concordance index (C-index) and Brier score, with 95% confi dence intervals reported. The gradient boosting model achieved the greatest perf ormance for 3-month survival (C-index: 0.8197, 95% CI 0.7682-0.868 9; Brier score: 0.1802), and the AdaBoost model achieved the greatest performanc e in 6-month survival (C-index: 0.8473, 95% CI 0.7979-0.8933; Brie r score: 0.1775). The SVC model showed superior performance for 12-month surviva l (C-index: 0.8347, 95% CI 0.7866- 0.8816; Brier score: 0.1476). Us ing SHAP with a gradient boosting model, the top five features affecting 6-month OS were identified: surgery, the presence of stage IVC, radiation, chemotherapy , and tumor size. Treatment improved survival, while higher stages reduced survi val, with smaller tumors generally linked to better outcomes. ML algorithms can accurately predict short-term survival in ATC patients."