查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – New research on Cerebrovascular Diseas es and Conditions - Stroke is the subject of a report. According to news reporti ng originating from Shenzhen, People’s Republic of China, by NewsRx corresponden ts, research stated, “Thrombolytic therapy is essential for acute ischemic strok e (AIS) management but poses a risk of hemorrhagic transformation (HT), necessit ating accurate prediction to optimize patient care. A comprehensive search was c onducted across PubMed, Web of Science, Scopus, Embase, and Google Scholar, cove ring studies from inception until July 10, 2024.” Our news editors obtained a quote from the research from the People’s Hospital o f Longhua, “Studies were included if they used machine learning (ML) or deep lea rning algorithms to predict HT in AIS patients treated with thrombolysis. Exclus ion criteria included studies involving endovascular treatments and those not ev aluating model effectiveness. Data extraction and quality assessment were perfor med following PRISMA guidelines and using the Transparent Reporting of a Multiva riable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) and Predi ction Model Risk of Bias Assessment Tool (PROBAST) tools. Out of 1943 identified records, 12 studies were included in the final analysis, encompassing 18 007 AI S patients who received thrombolytic therapy. The ML models demonstrated high pr edictive performance, with pooled area under the curve (AUC) values ranging from 0.79 to 0.95. Specifically, XGBoost models achieved AUCs of up to 0.953 and Art ificial Neural Network (ANN) models reached up to 0.942. Sensitivity and specifi city varied significantly, with the highest sensitivity at 0.90 and specificity at 0.99. Significant predictors of HT included age, glucose levels, NIH Stroke S cale (NIHSS) score, systolic and diastolic blood pressure, and radiomic features . Despite these promising results, methodological disparities and limited extern al validation highlighted the need for standardized reporting and further rigoro us testing. ML techniques, especially XGBoost and ANN, show great promise in pre dicting HT following thrombolysis in AIS patients, enhancing risk stratification and clinical decision-making.”