首页期刊导航|材料科学技术（英文版）
期刊信息/Journal information
材料科学技术（英文版）
材料科学技术（英文版）

胡壮麟

月刊

1005-0302

jmst@imr.ac.cn

024-83978208

110016

沈阳市沈河区文化路72号

材料科学技术（英文版）/Journal Journal of Materials Science & TechnologyCSCDCSTPCD北大核心EISCI
查看更多>>本刊简称《JMST》，（ISSN 1005-0302，CN 21-1315/TG）。1985年创刊。是中国科协主管，中国金属学会，中国材料研究学会和中国科学院金属研究所联合主办的国际性英文期刊，以“加强国际交流，扩大学术影响，服务经济建设”为办刊宗旨，刊登世界各国的具有创新性和较高学术水平的原始性论文，并设有物约综述、快报、简讯及国内外材料界杰出学者简介等栏目，内容包括金属材料、无机非金属材料、复合材料及有机高分子材料等。
正式出版
收录年代

    Silk microfibrous mats with long-lasting antimicrobial function

    Mi WuWen LiuJinrong YaoZhengzhong Shao...
    203-209页
    查看更多>>摘要：The controlled release of antibiotic drugs to injured sites has great advantages over the conventional intravenous administration of antibiotics,which is associated with systemic toxicity,for wound care.Electrospun nanofibrous/microfibrous mats,with a similar structure to the native extracellular matrix,is a promising wound dressing.Herein,drug-loaded halloysite nanotubes (HNTs) incorporated into regenerated silk fibroin (RSF) microfibrous mats were prepared by electrospinning to achieve sustained drug release and long-lasting antimicrobial protection.A broad-spectrum antibiotic,tetracycline hydrochloride (TCH),was selected as the model drug.Transmission electron microscopic images revealed that the TCH-loaded HNTs were homogeneously embedded in the RSF electrospun microfibers without significant changes in morphology.The drug release profiles showed that the RSF microfibrous mats with TCH-loaded HNTs exhibited a significantly reduced burst phase and a long release time over two weeks compared to the pure TCH-loaded HNTs and the TCH-loaded RSF microfibrous mats without HNTs.These results were attributed to the two-step release of TCH first from the HNTs and then RSF matrix in the electrospun mats.Finally,the antimicrobial properties of the RSF microfibrous mats with TCH-loaded HNTs were evaluated using both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria.The results demonstrated long-lasting antimicrobial activity for at least one week,showing the great potential ofTCH-loaded RSF microfibrous mat as a wound dressing material.Therefore,these TCH-loaded RSF microfibrous mats with excellent biocompatibility and sustained antimicrobial protection are extremely attractive systems for clinical applications.
      原文链接:
    • NETL
    • NSTL
    • 维普
    • 万方数据

    Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine

    Xiaoxue YuanRan LiuWenchang ZhangXiaoqiang Song...
    210-215页
    查看更多>>摘要：Controlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies,and it is important to predict and control the release kinetics to fully take advantage of this technology.Carboxylmethylchitosan (CMCS) and alginate (SA) blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere,which induced the protonation of the amino groups of CMCS,and the formation of polyelectrolyte composite hydrogels.By using diclofenac diethylamine as the model drug,the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment,which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the membrane.The study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems.
      原文链接:
    • NETL
    • NSTL
    • 维普
    • 万方数据

    Small extracellular vesicles secreted by urine-derived stem cells enhanced wound healing in aged mice by ameliorating cellular senescence

    Yongjin SunJuntao ZhangBi ChenYunlong Yang...
    216-227页
    查看更多>>摘要：Regeneration of chronic skin wounds in tissue is still a key challenge in regenerative medicine because of the accumulation of senescent cells and increasing secretion of (s)enescence-associated secretory phenotype=(SASP) in the wound site.Recently,some studies have reported that small extracellular vesicles (sEVs) derived from stem cells can alleviate cellular senescence with very low risk of tumorigenesis and immune responses.As our previous studies have shown that urine-derived stem cells (USCs) can be obtained easily and noninvasively and sEVs derived from USCs (USC-sEVs) have capabilities of regenerating tissue injuries,using USC-sEVs to enhance chronic skin wound healing in aged tissue might be a feasible and efficient strategy.Therefore,in this study,the USC-sEVs were collected and firstly loaded in a human acellular amniotic membrane (HAAM) for controlled releasing and locating the USC-sEVs in the wound site before they were implanted into a chronic skin wound in aged mice.In vivo results showed that the USC-sEVs in HAAM could effectively accelerate the wound healing by ameliorating cellular senescence and reducing the secretion of SASP in the aged skin wounds.To elucidate the mechanism,USC-sEVs were used to in vitro culture human dermal fibroblasts (HDFs) and results showed that USC-sEVs could rejuvenate senescent fibroblasts by reversing the aging phenotypes of senescent HDFs and efficiently reducing the secretion of SASP after they activated the Sirt1 pathway.Therefore,USC-sEVs are efficient for enhancing wound healing in aged mice by ameliorating cellular senescence.
      原文链接:
    • NETL
    • NSTL
    • 维普
    • 万方数据

    Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

    Yuxuan MaoPeng LiJiewei YinYanjie Bai...
    228-235页
    查看更多>>摘要：Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue repair.Nevertheless,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still lack.For this purpose,a series ofionically crosslinked starch hydrogels were developed here.The viscoelastic properties and tissue adhesiveness of the starch hydrogels were investigated.It is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue adhesiveness.Among the starch gels,there was one exhibiting a unique and stable "Gel Point" viscoelastic characteristic and it was named as gel-point adhesive hydrogel (GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and degradability.The GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial effect.The wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury model.The blood loss after the sealing of GPAH (2.4 ± 1.3 g) was significantly decreased compared to the group using gauze for sealing (6.3 ± 1.5g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the wound.The above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.
      原文链接:
    • NETL
    • NSTL
    • 维普
    • 万方数据

    Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

    Kai ChenChangci TongJinge YangPeifang Cong...
    236-245页
    查看更多>>摘要：Carboxymethyl chitosan (CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound healing.As a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen deposition.However,the combined effects of CMCS and melatonin on wound healing remain unclear.Injectable CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in rats.Compared with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen deposition.Additionally,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.The melatonin-loaded hydrogel also markedly increased the expression of collagen Ⅲ,u-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I expression.These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Instructions & Forms for Authors

    封3页
      原文链接:
    • NETL
    • NSTL
    • 万方数据