查看更多>>摘要：The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former surveillance data.In order to explore the potential genotoxicants contributing to the double-endpoint genotoxicity of polluted drinking water source,12 groundwater and 3 surface water samples were collected from 3 villages and the nearby rivers alongside Yinghe river basin,respectively and their comprehensive genotoxicity was estimated with a bioassay group of SOS/umu test and micronucleus (MN) test (MNT).Some groundwater samples showed positive genotoxicity and all surface water samples were highly genotoxic.Eight groundwater samples showed DNA genotoxic effect with the average 4-NQO equivalent concentration (TEQ(4-NQO)) of 0.067 μg/L and 0.089 μg/L in wet and dry season,respectively.The average MN ratios of groundwater samples were 14.19‰ and 17.52‰ in wet and dry season,respectively.Groundwater samples showed different genotoxic effect among 3 villages.The total PAHs concentrations in all water samples ranged from 8.98 to 25.17 ng/L with an average of 14.97±4.85 ng/L.BaA,CHR,BkF,BaP and DBA were the main carcinogenic PAHs contributing to the genotoxicity of water samples.In conclusion,carcinogenic PAHs are possibly related to the high tumor mortality in the target area.Characterization of carcinogenic PAHs to genotoxicity of drinking water source may shed light on the etiology study for high tumor mortality in Yinghe river basin.
查看更多>>摘要：Polycyclic aromatic hydrocarbons (PAHs) in indoor dust are one of the common exposure sources for children worldwide.The aim of this study is to explore PAHs pollution status in indoor dust and estimate health risk on Chinese children with big data.Weighted average concentration was used to analyze source and characterization of PAHs in indoor dust based on peer-reviewed literature.According to specific inclusion criteria,17 studies were included finally to analyze weighted average concentration.The national average concentration of Σ16PAHs was approximately 25.696 μg/g.The highest concentration of Σ16PAHs was in Shanxi (2111.667 μg/ g),and the lowest was in Hong Kong (1.505 μg/g).The concentrations in Shanxi and Guangdong were higher than national level and the over standard rate was 18.18％.The concentrations of individual PAHs varied greatly across the country,and Flu in Shanxi was the highest (189.400 μg/ g).The sources of PAHs varied in different regions and combustion processes played a leading role.PAHs exposure through ingestion and dermal contact was more carcinogenic than inhalation.The incremental lifetime cancer risk model indicated that children lived in Shanxi were found in the highest health risk coupled with the highest BaPE concentration (54.074 μg/g).Although PAHs concentrations of indoor dust showed a downward trend from 2005 to 2018,indoor environmental sanitation should be improved with multidisciplinary efforts.Health standard should be possibly established to minimize children exposure to PAHs in indoor dust in China.
查看更多>>摘要：Polycyclic aromatic hydrocarbons (PAHs) in indoor dust are one of the common exposure sources for children worldwide.The aim of this study is to explore PAHs pollution status in indoor dust and estimate health risk on Chinese children with big data.Weighted average concentration was used to analyze source and characterization of PAHs in indoor dust based on peer-reviewed literature.According to specific inclusion criteria,17 studies were included finally to analyze weighted average concentration.The national average concentration of Σ16PAHs was approximately 25.696 μg/g.The highest concentration of Σ16PAHs was in Shanxi (2111.667 μg/ g),and the lowest was in Hong Kong (1.505 μg/g).The concentrations in Shanxi and Guangdong were higher than national level and the over standard rate was 18.18％.The concentrations of individual PAHs varied greatly across the country,and Flu in Shanxi was the highest (189.400 μg/ g).The sources of PAHs varied in different regions and combustion processes played a leading role.PAHs exposure through ingestion and dermal contact was more carcinogenic than inhalation.The incremental lifetime cancer risk model indicated that children lived in Shanxi were found in the highest health risk coupled with the highest BaPE concentration (54.074 μg/g).Although PAHs concentrations of indoor dust showed a downward trend from 2005 to 2018,indoor environmental sanitation should be improved with multidisciplinary efforts.Health standard should be possibly established to minimize children exposure to PAHs in indoor dust in China.
查看更多>>摘要：The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data including infectious diarrhea cases among children under five years old and daily meteorological indexes in Jiangsu,China from 2015 to 2019 were collected.The lag-effects up to 21 days of daily maximum temperature (Tmax) on infectious diarrhea were explored using a quasi-Poisson regression with a distributed lag non-linear model (DLNM) approach.The cases number of infectious diarrhea was significantly associated with seasonal variation of meteorological factors,and the burden of disease mainly occurred among children aged 0-2 years old.Moreover,when the reference value was set at 16.7℃,Tmax had a significant lag-effect on cases of infectious diarrhea among children under 5 years old in Jiangsu Province,which was increased remarkably in cold weather with the highest risk at 8℃.The results of DLNM analysis implicated that the lag-effect of Tmax varied among the 13 cities in Jiangsu and had significant differences in 8 cities.The highest risk of Tmax was presented at 5 lag days in Huaian with a maximum RR of 1.18 (95％ CI: 1.09,1.29).Suzhou which had the highest number of diarrhea cases (15830 cases),had a maximum RR of 1.04 (95％ CI:1.03,1.05) on lag 15 days.Tmax is a considerable indicator to predict the epidemic of infectious diarrhea among 13 cities in Jiangsu,which reminds us that in cold seasons,more preventive strategies and measures should be done to prevent infectious diarrhea.
查看更多>>摘要：The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data including infectious diarrhea cases among children under five years old and daily meteorological indexes in Jiangsu,China from 2015 to 2019 were collected.The lag-effects up to 21 days of daily maximum temperature (Tmax) on infectious diarrhea were explored using a quasi-Poisson regression with a distributed lag non-linear model (DLNM) approach.The cases number of infectious diarrhea was significantly associated with seasonal variation of meteorological factors,and the burden of disease mainly occurred among children aged 0-2 years old.Moreover,when the reference value was set at 16.7℃,Tmax had a significant lag-effect on cases of infectious diarrhea among children under 5 years old in Jiangsu Province,which was increased remarkably in cold weather with the highest risk at 8℃.The results of DLNM analysis implicated that the lag-effect of Tmax varied among the 13 cities in Jiangsu and had significant differences in 8 cities.The highest risk of Tmax was presented at 5 lag days in Huaian with a maximum RR of 1.18 (95％ CI: 1.09,1.29).Suzhou which had the highest number of diarrhea cases (15830 cases),had a maximum RR of 1.04 (95％ CI:1.03,1.05) on lag 15 days.Tmax is a considerable indicator to predict the epidemic of infectious diarrhea among 13 cities in Jiangsu,which reminds us that in cold seasons,more preventive strategies and measures should be done to prevent infectious diarrhea.
查看更多>>摘要：Risk factors for adverse pregnancy outcomes among Zhuang ethnic pregnant women are unclear.This study analyzed the incidence and risk factors related to preterm birth (PB),low birth weight (LBW) and macrosomia in Zhuang population.We conducted a prospective cohort study of 9965 Zhuang pregnancy women in Guangxi,China.Information on mothers and newborns was obtained by using questionnaires and referring to medical records.Multivariate logistic regression analyses were used to evaluate the association between related factors and adverse pregnancy outcomes.Our results showed that the incidence of PB,LBW and macrosomia in Zhuang people was 5.55％,5.64％ and 2.19％,respectively.Maternal age ≥36 years (OR=2.22,95％ CI: 1.51-3.27) was related to a higher incidence of PB.Those with pre-pregnancy body mass index (BMI) ＜18.5 kg/m2 (OR=1.91,95％ CI: 1.45-2.51),and had a female fetus (OR=1.74,95％ CI:1.36-2.23) were more likely to have LBW infants.Maternal age between 31 and 35 years (OR=1.76,95％ CI: 1.03-2.99) and pre-pregnancy overweight or obesity (OR=1.79,95％ CI: 1.15-2.80) were associated with a higher risk of macrosomia.The protective factors of macrosomia were maternal pre-pregnancy BMI ＜18.5 kg/m2 (OR=0.30,95％ CI: 0.15-0.60) and female fetus (OR=0.41,95％ CI: 0.28-0.59).Our study provided a reference for maternal and childcare administration among Zhuang population.
查看更多>>摘要：Risk factors for adverse pregnancy outcomes among Zhuang ethnic pregnant women are unclear.This study analyzed the incidence and risk factors related to preterm birth (PB),low birth weight (LBW) and macrosomia in Zhuang population.We conducted a prospective cohort study of 9965 Zhuang pregnancy women in Guangxi,China.Information on mothers and newborns was obtained by using questionnaires and referring to medical records.Multivariate logistic regression analyses were used to evaluate the association between related factors and adverse pregnancy outcomes.Our results showed that the incidence of PB,LBW and macrosomia in Zhuang people was 5.55％,5.64％ and 2.19％,respectively.Maternal age ≥36 years (OR=2.22,95％ CI: 1.51-3.27) was related to a higher incidence of PB.Those with pre-pregnancy body mass index (BMI) ＜18.5 kg/m2 (OR=1.91,95％ CI: 1.45-2.51),and had a female fetus (OR=1.74,95％ CI:1.36-2.23) were more likely to have LBW infants.Maternal age between 31 and 35 years (OR=1.76,95％ CI: 1.03-2.99) and pre-pregnancy overweight or obesity (OR=1.79,95％ CI: 1.15-2.80) were associated with a higher risk of macrosomia.The protective factors of macrosomia were maternal pre-pregnancy BMI ＜18.5 kg/m2 (OR=0.30,95％ CI: 0.15-0.60) and female fetus (OR=0.41,95％ CI: 0.28-0.59).Our study provided a reference for maternal and childcare administration among Zhuang population.
查看更多>>摘要：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with unknown origin spread rapidly to 222 countries,areas or territories.To investigate the genomic evolution and variation in the early phase of COVID-19 pandemic in Guangdong,60 specimens of SARS-CoV-2 were used to perform whole genome sequencing,and genomics,amino acid variation and Spike protein structure modeling analyses.Phylogenetic analysis suggested that the early variation in the SARS-CoV-2 genome was still intra-species,with no evolution to other coronaviruses.There were one to seven nucleotide variations (SNVs) in each genome and all SNVs were distributed in various fragments of the genome.The Spike protein bound with human receptor,an amino acid salt bridge and a potential furin cleavage site were found in the SARS-CoV-2 using molecular modeling.Our study clarified the characteristics of SARS-CoV-2 genomic evolution,variation and Spike protein structure in the early phase of local cases in Guangdong,which provided reference for generating prevention and control strategies and tracing the source of new outbreaks.
查看更多>>摘要：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with unknown origin spread rapidly to 222 countries,areas or territories.To investigate the genomic evolution and variation in the early phase of COVID-19 pandemic in Guangdong,60 specimens of SARS-CoV-2 were used to perform whole genome sequencing,and genomics,amino acid variation and Spike protein structure modeling analyses.Phylogenetic analysis suggested that the early variation in the SARS-CoV-2 genome was still intra-species,with no evolution to other coronaviruses.There were one to seven nucleotide variations (SNVs) in each genome and all SNVs were distributed in various fragments of the genome.The Spike protein bound with human receptor,an amino acid salt bridge and a potential furin cleavage site were found in the SARS-CoV-2 using molecular modeling.Our study clarified the characteristics of SARS-CoV-2 genomic evolution,variation and Spike protein structure in the early phase of local cases in Guangdong,which provided reference for generating prevention and control strategies and tracing the source of new outbreaks.
查看更多>>摘要：Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,environmental pollutants have caused great harm to public health.Phthalates,as a class of endocrine-disrupting chemicals (EDCs),are synthesized and used in large quantities as plasticizers due to their chemical properties.They are easily released into environment because of their noncovalent interactions with substances,causing human exposure and possibly impairing ovary.In recent years,more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases.And it is urgent to study the role of methylation,gene imprinting,miRNA,and other epigenetic mechanisms in reproductive toxicology.
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