期刊,国际肝胆胰疾病杂志（英文版） 2024年卷1期_国家学术搜索

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首页期刊导航|国际肝胆胰疾病杂志（英文版）

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国际肝胆胰疾病杂志（英文版）

浙江省医学学术交流管理中心、浙江大学医学院附属第一医院、浙江大学出版社有限责任公司

主办单位：浙江省医学学术交流管理中心、浙江大学医学院附属第一医院、浙江大学出版社有限责任公司

出版周期：双月

国际刊号：1499-3872

电子邮箱：hbpdint@126.com

电　　话：0571-87236559

邮政编码：310003

地　　址：杭州市上城区庆春路79号

国际肝胆胰疾病杂志（英文版）/Journal Hepatobiliary & Pancreatic Diseases InternationalCSCD北大核心SCI

查看更多>>《国际肝胆胰疾病杂志（英文版）》（双月刊），创刊于2002年，由浙江省卫生厅主管，浙江大学医学院附属第一医院主办。杂志涵盖主题领域包括医学、外科、放射学、病理学、生化、生理学和组织学等方面的内容。

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Early systemic anticoagulation reduces hospital readmission in acute necrotizing pancreatitis patients:A retrospective cohort study

Wen-Jian MaoJing ZhouGuo-Fu ZhangFa-Xi Chen...

77-82页

查看更多>>摘要：Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been assessed.However,whether it affects long-term outcomes is unknown.This study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP patients.Methods:During January 2013 and December 2018,ANP patients admitted within 7 days from the on-set of abdominal pain were screened.The primary outcome was 90-day readmission after discharge.Cox proportional-hazards regression model and mediation analysis were used to define the relationship be-tween early SAC and 90-day readmission.Results:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospi-talization and 98 did not.Patients who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95％CI:0.26-0.60,P＜0.01]and lower 90-day read-mission with an RR of 0.61(95％CI:0.41-0.91,P=0.02)than those who did not.For the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two groups.Multivariable Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjust-ing for potential confounders with a hazard ratio of 0.57(95％Cl:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0％of the early SAC-90-day readmission causality.Conclusions:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.

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