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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Where are we?

    Ingmar K(o)nigsrainerStefan Beckert
    5317-5320页
    查看更多>>摘要：Peritoneal surface malignancies are generally associated with poor prognosis.In daily clinical routine,systemic chemotherapy is still considered the only reasonable therapy despite of encouraging results of cytoreductive surgery (CRS) along with intraperitoneal hyperthermic chemotherapy (HIPEC).The Achilles heel of CRS and HIPEC is appropriate patient selection and precise surgical technique preventing patients from excessive morbidity and mortality.Given these findings,new concepts of second look surgery for high risk patients allow detection of peritoneal spread ahead of clinical symptoms or presence of peritoneal masses reducing perioperative morbidity.In addition,personalized intraperitoneal chemotherapy might further improve outcome by appreciating individual tumor biology.These days,every physician should be aware of CRS and HIPEC for treatment of peritoneal surface malignancies.Since there is now sufficient data for the superiority of CRS and HIPEC to systemic chemotherapy in selected patients,our next goal should be providing this strategy with minimal morbidity and mortality even in the presence of higher tumor load.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    c-Met in pancreatic cancer stem cells: Therapeutic implications

    Marta Herreros-VillanuevaAizpea Zubia-OlascoagaLuis Bujanda
    5321-5323页
    查看更多>>摘要：Pancreatic cancer is the deadliest solid cancer and currently the fourth most frequent cause of cancer-related deaths.Emerging evidence suggests that cancer stem cells (CSCs) play a crucial role in the development and progression of this disease.The identification of CSC markers could lead to the development of new therapeutic targets.In this study,the authors explore the functional role of c-Met in pancreatic CSCs,by analyzing self-renewal with sphere assays and tumorigenicity capacity in NOD SCID mice.They concluded that c-Met is a novel marker for identifying pancreatic CSCs and c-Methigh in a higher tumorigenic cancer cell population.Inhibition of c-Met with XL184 blocks self-renewal capacity in pancreatic CSCs.In pancreatic tumors established in NOD SCID mice,c-Met inhibition slowed tumor growth and reduced the population of CSCs,along with preventing the development of metastases.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Magnets, children and the bowel: A dangerous attraction?

    Anil Thomas GeorgeSandeep Motiwale
    5324-5328页
    查看更多>>摘要：Reports of magnet ingestion are increasing rapidly globally.However,multiple magnet ingestion,the subsequent potential complications and the importance of the early identification and proper management remain both under-recognized and underestimated.Published literature on such cases could possibly represent only the tip of an iceberg with press reports,web blogs and government documents highlighting further occurrence of many more such incidents.The increasing number of complications worldwide being reported secondary to magnet ingestion point not only to an acute lack of awareness about this condition among the medical profession but also among parents and carers who will be in most cases the first to pick up on magnet ingestion.There still seems to be no consensus on the management of magnet ingestion with several algorithms being proposed for management.Prevention of this condition remains a much better option than cure.Proper education and improved awareness among parents and carers and frontline medical staff is key in addressing this rapidly emerging problem.The goal of managing such cases of suspected magnet ingestion should be aimed at reducing delays between ingestion time,diagnosis time and intervention time.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Laparoscopic distal pancreatectomy: Up-to-date and literature review

    Maurizio IacoboneMarilisa CittonDonato Nitti
    5329-5337页
    查看更多>>摘要：Pancreatic surgery represents one of the most challenging areas in digestive surgery.In recent years,an increasing number of laparoscopic pancreatic procedures have been performed and laparoscopic distal pancreatectomy (LDP) has gained world-wide acceptance because it does not require anastomosis or other reconstruction.To date,English literature reports more than 300 papers focusing on LDP,but only 6％ included more than 30 patients.Literature review confirms that LDP is a feasible and safe procedure in patients with benign or low grade malignancies.Decreased blood loss and morbidity,early recovery and shorter hospital stay may be the main advantages.Several concerns still exist for laparoscopic pancreatic adenocarcinoma excision.The individual surgeon determines the technical conduction of LDP,with or without spleen preservation;currently robotic pancreatic surgery has gained diffusion.Additional researches are necessary to determine the best technique to improve the procedure results.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Theoretical basis of a beneficial role for vitamin D in viral hepatitis

    Khanh vinh qu(o)c L(u)(o)ngLan Thi Hoàng Nguy(e)n
    5338-5350页
    查看更多>>摘要：Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis.Some studies suggested a relationship between vitamin D and viral hepatitis.Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the pathology of viral hepatitis (i.e.,the major histocompatibility complex class Ⅱ molecules,the vitamin D receptor,cytochrome P450,the renin-angiotensin system,apolipoprotein E,liver X receptor,toll-like receptor,and the proteins regulated by the Sp1 promoter gene).Vitamin D also exerts its effects on viral hepatitis via non-genomic factors,i.e.,matrix metalloproteinase,endothelial vascular growth factor,prostaglandins,cyclooxygenase-2,and oxidative stress.In conclusion,vitamin D could have a beneficial role in viral hepatitis.Calcitriol is best used for viral hepatitis because it is the active form of the vitamin D3 metabolite.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

    David PhilippeViral BrahmbhattFrancis FoataYen Saudan...
    5351-5359页
    查看更多>>摘要：AIM:To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB),both in vitro and using a mouse model of experimental colitis.METHODS:The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line.in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NF-κB) activation,utilizing reporter cell lines.Following the in vitro assessment,the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using a preclinical model of intestinal inflammation.Multiple outcomes including body weight,intestinal histology,colonic cytokine levels and anti-oxidative measures were investigated.RESULTS:LWB reduced the LPS-mediated induction of ROS production [+LPS vs 1％ LWB + LPS,1590 ±188.5 relative luminescence units (RLU) vs 389 ± 5.9RLU,P ＜ 0.001].LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5％ LWB,15％ ± 7.8％ vs 64％ ±5％,P ＜ 0.001).In addition,LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB,73％ ± 6.9％ vs 148％± 28.3％,P ＜ 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB,10％ ±6.7％ vs 35％ ± 3.3％,P ＜ 0.05).Furthermore,oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB,5.39 ± 0.61 vs 3.66 ±0.59,P =0.0445) and histological scores (-LWB vs +LWB,5.44 ± 0.32 vs 3.66 ± 0.59,P =0.0087) in colitic mice.These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB,570 ± 245 μg/L vs 89 ± 38 μg/L,P =0.0106),keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB,184± 49 μg/L vs 75 ± 20 μg/L,P =0.0244),IL-6 (-LWB vs +LWB,318 ± 99 μg/L vs 117 ± 18 μg/L,P =0.0315)and other pro-inflammatory proteins such as cyclooxygenase-2 (-LWB vs +LWB,0.95 ± 0.12 AU vs 0.36± 0.11 AU,P =0.0036) and phosphorylated signal transducer and activator of transcription-3 (-LWB vs +LWB,0.51 ± 0.15 AU vs 0.1 ± 0.04 AU,P =0.057).Moreover,antioxidant biomarkers,including expression of gene encoding for the glutathione peroxidase,in the colon and the plasma anti-oxidant capacity were significantly increased by supplementation with LWB (-LWB vs +LWB,1.2 ± 0.21 mmol/L vs 2.1 ± 0.19 mmol/L,P=0.0095).CONCLUSION:These results demonstrate the antiinflammatory properties of LWB and suggest that the underlying mechanism is at least in part due to NF-κB inhibition and improved anti-oxidative capacity.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

    Kunihiro HosonoEiji YamadaHiroki EndoHirokazu Takahashi...
    5360-5368页
    查看更多>>摘要：AIM:To determine the expression statuses of tumor necrosis factor (TNF)-α,its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas.METHODS:We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls.The protein expression of TNF-α,TNF-R1,TNF-R2 and downstream signals of the TNF receptors,such as c-Jun N-terminal kinase (JNK),nuclear factor-κ B and caspase-3,were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry.Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK).RESULTS:The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL,P ＜ 0.001).Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928)for the diagnosis of adenoma,and the best cut-off level of TNF-R1 was 2.08 ng/mL,with a sensitivity of 93.4％ and a specificity of 82.4％.There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups.Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas.Furthermore,a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue.CONCLUSION:TNF-R1 may be a promising biomarker of colorectal adenoma,and it may also play an important role in the very early stages of colorectal carcinogenesis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Axl glycosylation mediates tumor cell proliferation,invasion and lymphatic metastasis in murine hepatocellular carcinoma

    Ji LiLi JiaZhen-Hai MaQiu-Hong Ma...
    5369-5376页
    查看更多>>摘要：AIM:To investigate the effects of Axl deglycosylation on tumor lymphatic metastases in mouse hepatocellular carcinoma cell lines.METHODS:Western blotting was used to analyze the expression profile of Axl glycoprotein in mouse hepatocellular carcinoma cell line Hca-F treated with tunicamycin and PNGase F 3-(4,5)-dimethylthiazol(-zyl)-3,5-diphenyltetrazolium bromide (MTT) assay,extracellular matrix (ECM) invasion assay (in vitro) and tumor metastasis assay (in vivo) were utilized to evaluate the effect of Axl deglycosylation on the Hca-F cell proliferation,invasion and lymphatic metastasis.RESULTS:Tunicamycin and PNGase F treatment markedly inhibited Axl glycoprotein synthesis and expression,proliferation,invasion,and lymphatic metastasis both in vitro and in vivo.In the MTT assay,proliferation was apparent in untreated Hca-F cells compared with treated Hca-F cells.In the ECM invasion assay (in vitro),treated cells passed through the ECMatrix gel in significantly smaller numbers than untreated cells (tunicamycin 5 μg/mL:68 ± 8 vs 80 ± 9,P =0.0222; 10μg/mL:50 ± 6 vs 80 ± 9,P =0.0003; 20 lμg/mL:41 ±4 vs 80 ± 9,P =0.0001); (PNGase F 8 h:66 ± 7 vs 82± 8,P =0.0098; 16 h:49 ± 4 vs 82 ± 8,P =0.0001;24 h:34 ± 3 vs 82 ± 8,P =0.0001).In the tumor metastasis assay (in vivo),average lymph node weights of the untreated Hca-F group compared with treated Hca-F groups (tunicamycin 5 μg/mL:0.84 ± 0.21 g vs 0.72 ± 0.19 g,P =0.3237; 10 μg/mL:0.84 ± 0.21 g vs 0.54 ± 0.11 g,P =0.0113; 20 μg/mL:0.84 ± 0.21 g vs 0.42 ± 0.06 g,P =0.0008); (PNGase F 8 h:0.79 ± 0.15 g vs 0.63 ± 0.13 g,P =0.0766; 16 h:0.79 ± 0.15g vs 0.49 ± 0.10 g,P =0.0022; 24 h:0.79 ± 0.15 g vs0.39 ± 0.05 g,P =0.0001).Also,average lymph node volumes of the untreated Hca-F group compared with treated Hca-F groups (tunicamycin 5 μg/mL:815 ± 61mm3 vs 680 ± 59 mm3,P =0.0613; 10 μg/mL:815 ±61 mm3 vs 580 ± 29 mm3,P =0.0001; 20 μg/mL:815± 61 mm3 vs 395 ± 12 mm3,P =0.0001); (PNGase F 8 h:670 ± 56 mm3 vs 581 ± 48 mm3,P =0.0532; 16h:670 ± 56 mm3 vs 412 ± 22 mm3,P =0.0001; 24 h:670 ± 56 mm3 vs 323 ± 11 mm3,P =0.0001).CONCLUSION:Alteration of Axl glycosylation can attenuate neoplastic lymphatic metastasis.Axl N-glycans may be a universal target for chemotherapy.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Protection of ghrelin postconditioning on hypoxia/reoxygenation in gastric epithelial cells

    Zhang-Bo LiuSu-Juan FeiSheng-Ping ZhuJin-Zhou Zhu...
    5377-5388页
    查看更多>>摘要：AIM:To investigate the protective effect and mechanisms of ghrelin postconditioning against hypoxia/reoxygenation (H/R)-induced injury in human gastric epithelial cells.METHODS:The model of H/R injury was established in gastric epithelial cell line (GES-1) human gastric epithelial cells.Cells were divided into seven groups:normal control group (N); H/R postconditioning group;DMSO postconditioning group (DM); ghrelin postconditioning group (GH); D-Lys3-GHRP-6 + ghrelin postconditioning group (D + GH); capsazepine + ghrelin postconditioning group (C + GH); and LY294002 +ghrelin postconditioning group (L + GH).3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to detect GES-1 cell viability.Hoechst 33258 fluorochrome staining and flow cytometry were conducted to determine apoptosis of GES-1 cells.Spectrophotometry was performed to determine release of lactate dehydrogenate (LDH).Protein expression of Bcl-2,Bax,Akt,and glycogen synthase kinase (GSK)-3β was determined by western blotting.Expression of vanilloid receptor subtype 1 (VR1),Akt and GSK-3β was observed by immunocytochemistry.RESULTS:Compared with the H/R group,cell viability of the GH group was significantly increased in a dosedependent manner (55.9％ ± 10.0％ vs 69.6％ ± 9.6％,71.9％ ± 17.4％,and 76.3％ ± 13.3％).Compared with the H/R group,the percentage of apoptotic cells in the GH group significantly decreased (12.38％ ± 1.51％ vs 6.88％ ± 0.87％).Compared with the GH group,the percentage of apoptotic cells in the D + GH group,C + GH group and L + GH groups significantly increased (11.70％ ± 0.88％,11.93％ ± 0.96％,10.20％ ± 1.05％vs 6.88％ ± 0.87％).There were no significant differences in the percentage of apoptotic cells between the H/R and DM groups (12.38％ ± 1.51％ vs13.00％± 1.13％).There was a significant decrease in LDH release following ghrelin postconditioning compared with the H/R group (561.58 ± 64.01 U/L vs 1062.45 ±105.29 U/L).There was a significant increase in LDH release in the D + GH,C + GH and L + GH groups compared with the GH group (816.89 ± 94.87 U/L,870.95 ± 64.06 U/L,838.62 ± 118.45 U/L vs 561.58± 64.01 U/L).There were no significant differences in LDH release between the H/R and DM groups (1062.45± 105.29 U/L vs 1017.65 ± 68.90 U/L).Compared with the H/R group,expression of Bcl-2 and Akt increased in the GH group,whereas expression of Bax and GSK-3β decreased.Compared with the GH group,expression of Bcl-2 decreased and Bax increased in the D + GH,C + GH and L + GH groups,and Akt decreased and GSK-3β increased in the L + GH group.The H/R group also upregulated expression of VR1 and GSK-3βand downregulated Akt.The number of VR1-positive and Akt-positive cells in the GH group significantly increased,whereas the number of GSK-3β-positive cells significantly decreased.These effects of ghrelin were reversed by capsazepine and LY294002.CONCLUSION:Ghrelin postconditioning protected against H/R-induced injury in human gastric epithelial cells,which indicated that this protection might be associated with GHS-R,VR1 and the PI3K/Akt signaling pathway.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Carbon dioxide accumulation during analgosedated colonoscopy: Comparison of propofol and midazolam

    Ludwig T HeussShajan Peter SugandhaChristoph Beglinger
    5389-5396页
    查看更多>>摘要：AIM:To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol.METHODS:Consecutive patients undergoing routine colonoscopy were randomly assigned to sedation with either propofol or midazolam in an open-labeled design using a titration scheme.All patients received 4 μg/kg per body weight alfentanil for analgesia and 3 L of supplemental oxygen.Oxygen saturation (SpO2) was measured by pulse oximetry (POX),and capnography (PcCO2) was continuously measured using a combined dedicated sensor at the ear lobe.Instances of apnea resulting in measures such as stimulation of the patient,a chin lift,a mask maneuver,or withholding of sedation were recorded.PcCO2 values (as a parameter of sedation-induced hypoventilation) were compared between groups at the following distinct time points:baseline,maximal rise,termination of the procedure and 5 min after termination of the procedure.The number of patients in both study groups who regained baseline PcCO2 values (± 1.5 mmHg) five minutes after the procedure was determined.RESULTS:A total of 97 patients entered this study.The data from 14 patients were subsequently excluded for clinical procedure-related reasons or for technical problems.Therefore,83 patients (mean age 62 ± 13 years) were successfully randomized to receive propofol (n =42) or midazolam (n =41) for sedation.Most of the patients were classified as American Society of Anesthesiologists (ASA) Ⅱ [16 (38％) in the midazolam group and 15 (32％) in the propofol group] and ASA Ⅲ [14 (33％) and 13 (32％) in the midazolam and propofol groups,respectively].A mean dose of 5 (4-7) mg of Ⅳ midazolam and 131 (70-260) mg of Ⅳ propofol was used during the procedure in the corresponding study arms.The mean SpO2 at baseline (％) was 99± 1 for the midazolam group and 99 ± 1 for the propofol group.No cases of hypoxemia (SpO2 ＜ 85％) or apnea were recorded.However,an increase in PcCO2 that indicated alveolar hypoventilation occurred in both groups after administration of the first drug and was not detected with pulse oximetry alone.The mean interval between the initiation of sedation and the time when the PcCO2 value increased to more than 2 mmHg was 2.8 ± 1.3 min for midazolam and 2.8 ± 1.1 min for propofol.The mean maximal rise was similar for both drugs:8.6 ± 3.7 mmHg for midazolam and 7.4 ± 3.2mmHg for propofol.Five minutes after the end of the procedure,the mean difference from the baseline values was significantly lower for the propofol treatment compared with midazolam (0.9 ± 3.0 mmHg vs 4.3 ±3.7 mmHg,P =0.0000169),and significantly more patients in the propofol group had regained their baseline value ± 1.5 mmHg (32 of 41 vs 12 of 42,P =0.0004).CONCLUSION:A significantly higher number of patients sedated with propofol had normalized PcCO2 values five minutes after sedation when compared with patients sedated with midazolam.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普