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细胞研究（英文版）
细胞研究（英文版）

裴钢

月刊

cellres@sibs.ac.cn

021-54920953，4920952

200031

上海岳阳路319号中科院上海生命科学研究院31B，401室

细胞研究（英文版）/Journal Cell ResearchCSCDCSTPCD北大核心SCI
查看更多>>Cell Research为中国科学院上海生命科学研究院主办，以全英文刊登国内外细胞生物学及其相关领域的原创性研究论文、综述、快报和述评的国际性期刊。已被Index Medicus,Medline, SCI (SciSearch ISI Web of Science), BIOSIS, CA, VINIT以及《中国科学引文数据库》、《万方数据库》（光盘版，网络版）、《中国英文版科技期刊数据库》、《中文科技期刊数据库》、《中国学术期刊》（光盘版，网络版）、《台湾华艺中文电子期刊服务》等国内外十多种大型期刊检索数据库收录。Cell Research是美国ISI SCI细胞生物学领域收录的唯一中国期刊，2004年度的SCI影响因子是1.936，在71份入选中国期刊中位列第二，杂志论文的他引率大于90%。
正式出版
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    Tau(t)ing glucocorticoid binding

    Sabine VettorazziJan Tuckermann
    1-2页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Deciphering the role of immune system in the obesity-cancer relationship

    Camille BlériotGerasimos AnagnostopoulosFlorent Ginhoux
    3-4页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    LKB1 inactivation unleashes prostate cancer lineage plasticity

    Shaghayegh NouruziAmina Zoubeidi
    5-6页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Immunity hubs orchestrating antiviral defense

    Linnan ZhuZemin Zhang
    7-8页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    NLRC5 PANoptosome:Aquaman of the Dead Sea

    Poonam S.JadhavShreya MahajanSi Ming Man
    9-10页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Modern biology of extrachromosomal DNA:A decade-long voyage of discovery

    Qing-Lin YangYipeng XieKailiang QiaoJun Yi Stanley Lim...
    11-22页
    查看更多>>摘要：Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis.A key manifestation of genomic instability is the formation of extrachromosomal DNAs(ecDNAs)—acentric,circular DNA molecules ranging from 50 kb to 5 Mb in size,distinct from chromosomes.Ontological studies have revealed that ecDNA serves as a carrier of oncogenes,immunoregulatory genes,and enhancers,capable of driving elevated transcription of its cargo genes and cancer heterogeneity,leading to rapid tumor evolution and therapy resistance.Although ecDNA was documented over half a century ago,the past decade has witnessed a surge in breakthrough discoveries about its biological functions.Here,we systematically review the modern biology of ecDNA uncovered over the last ten years,focusing on how discoveries during this pioneering stage have illuminated our understanding of ecDNA-driven transcription,heterogeneity,and cancer progression.Furthermore,we discuss ongoing efforts to target ecDNA as a novel approach to cancer therapy.This burgeoning field is entering a new phase,poised to reshape our knowledge of cancer biology and therapeutic strategies.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss

    Wenyu FuMeng ChenKaidi WangYujianan Chen...
    23-44页
    查看更多>>摘要：Glucocorticoids(GCs)are the most prescribed anti-inflammatory and immunosuppressive drugs.However,their use is often limited by substantial side effects,such as GC-induced osteoporosis(GIO)with the underlying mechanisms still not fully understood.In this study,we identify Tau as a low-affinity binding receptor for GCs that plays a crucial role in GIO.Tau deficiency largely abolished bone loss induced by high-dose dexamethasone,a synthetic GC,in both inflammatory arthritis and GIO models.Furthermore,TRx0237,a Tau inhibitor identified from an FDA-approved drug library,effectively prevented GIO.Notably,combinatorial administration of TRx0237 and dexamethasone completely overcame the osteoporosis adverse effect of dexamethasone in treating inflammatory arthritis.These findings present Tau as a previously unrecognized GC receptor with low affinity,and provide potential strategies to mitigate a spectrum of GC-related adverse effects,particularly osteoporosis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice

    Yuting WangWenhao ZhangChao ZhangHoang Q.Tran Van...
    45-58页
    查看更多>>摘要：Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences.Developing effective anti-aging strategies is of great significance.In this study,we demonstrated that transplantation of young hematopoietic stem cells(HSCs)into old mice can mitigate aging phenotypes,underscoring the crucial role of HSCs in the aging process.Through comprehensive molecular and functional analyses,we identified a subset of HSCs in aged mice that exhibit"younger"molecular profiles and functions,marked by low levels of CD150 expression.Mechanistically,CD1501ow HSCs from old mice but not their CD150high counterparts can effectively differentiate into downstream lineage cells.Notably,transplantation of old CD150low HSCs attenuates aging phenotypes and prolongs lifespan of elderly mice compared to those transplanted with unselected or CD150high HSCs.Importantly,reducing the dysfunctional CD150high HSCs can alleviate aging phenotypes in old recipient mice.Thus,our study demonstrates the presence of"younger"HSCs in old mice,and that aging-associated functional decline can be mitigated by reducing dysfunctional HSCs.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer

    Fei LiPengfei DaiHuili ShiYajuan Zhang...
    59-71页
    查看更多>>摘要：Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression,thereby shaping tumor heterogeneity and therapy response.In castration-resistant prostate cancer(CRPC),the intricacies behind androgen receptor(AR)-independent lineage plasticity remain unclear,leading to a scarcity of effective clinical treatments.Utilizing single-cell RNA sequencing on both human and mouse prostate cancer samples,combined with whole-genome bisulfite sequencing and multiple genetically engineered mouse models,we investigated the molecular mechanism of AR-independent lineage plasticity and uncovered a potential therapeutic strategy.Single-cell transcriptomic profiling of human prostate cancers,both pre-and post-androgen deprivation therapy,revealed an association between liver kinase B1(LKB1)pathway inactivation and AR independence.LKB1 inactivation led to AR-independent lineage plasticity and global DNA hypomethylation during prostate cancer progression.Importantly,the pharmacological inhibition of TET enzymes and supplementation with S-adenosyl methionine were found to effectively suppress AR-independent prostate cancer growth.These insights shed light on the mechanism driving AR-independent lineage plasticity and propose a potential therapeutic strategy by targeting DNA hypomethylation in AR-independent CRPC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy

    Qianhui XuHuilan WangRuonan YangYouqi Tao...
    72-75页
      原文链接:
    • NETL
    • NSTL
    • 万方数据