首页期刊导航|中华生物医学工程杂志
期刊信息/Journal information
中华生物医学工程杂志
中华生物医学工程杂志

钟南山

双月刊

1674-1927

cjbme@vip.tom.com

020-81340157

510182

广东省广州市东风西路195号广州医学院内28栋1楼

中华生物医学工程杂志/Journal Chinese Journal of Biomedical EngineeringCSTPCD
查看更多>>中华医学会、广州医学院主办。本刊办刊宗旨：密切关注并报道生物医学工程学研究的新理论、新方法、新技术，跟踪生物医学工程学在临床中的最新应用成果，服务广大临床医生，促进生物医学工程学的学科发展。生物医学工程的发展一直是临床医学进步的动力，而临床医学所需要解决的问题则是生物医学工程创新的源泉。临床医生、科学家和产业界工程技术人员的紧密合作将为人类创造更美好的健康长寿的新生活。内容和栏目：（1）编者导读；（2）专论；（3）论著；（4）新技术与临床；（5）新技术研发；（6）生物技术；（7）综述；（8）专题讲座。
正式出版
收录年代

    基于四维磁共振血流加速度成像的血管狭窄模型压力梯度的评估

    顾安燕刘泽萍刘红艳刘洋...
    241-247页
    查看更多>>摘要：目的 探讨使用四维磁共振血流加速度成像技术在不同空间分辨率下重建压力梯度的可靠性和准确性。 方法 构建一种血管狭窄的流体模型，并使用四维磁共振速度成像序列和课题组自主研发的四维加速度成像序列对该模型进行扫描，扫描的空间分辨率有0.63 mm×0.63 mm×0.63 mm和0.89 mm×0.89 mm×0.89 mm两种，采集得到流体模型在两种不同空间分辨率下的速度和加速度数据，根据Naver-Stokes方程，使用中心有限差分方法计算得到流体模型狭窄两端的压力梯度，并以压力传感器测量的压力差为标准，计算Fréchet距离和最大相对误差以及进行回归分析等来对其准确性和相关性进行评估。 结果 两种空间分辨率下，直接加速度计算的压力梯度都比速度求导计算的压力梯度误差更小、准确性更高：在0.63 mm分辨率下，直接加速度计算和速度求导计算的压力梯度变化曲线与压力传感器得到的曲线之间的Fréchet距离d f分别为0.84和1.32，最大相对误差（εmax）分别为13.9%和21.2%，在0.89 mm分辨率下d f分别为1.33和1.60，εmax分别为29.4%和33.2%。空间分辨率对压力梯度的计算有明显影响：0.63 mm和0.89 mm分辨率下，加速度与速度计算得到的压力梯度回归斜率k分别为0.72和0.62以及0.51和0.44，R2分别为0.97和0.91以及0.91和0.72。 结论 四维磁共振血流加速度成像重建压力梯度具有很大潜力，得到的压力梯度的准确性比速度求导计算得到压力梯度的准确性更高，同时结果误差还随分辨率的增高而减小。 Objective To probe the reliability and accuracy of pressure gradient reconstructed using four-dimensional magnetic resonance blood flow acceleration imaging at different spatial resolutions. Methods A fluid model of vascular stenosis was constructed, and the model was scanned by the four-dimensional magnetic resonance velocity imaging sequence and acceleration imaging sequence independently developed by the research group. The spatial resolution of the scanning was 0.63 mm 0.63 mm 0.63 mm and 0.89 mm 0.89 mm 0.89 mm, respectively. The acceleration and velocity data obtained from magnetic resonance images were used to calculate pressure gradient of the fluid phantom through solving Navier-Stokes equation with using central finite difference over two different spatial resolutions. The Fréchet distance, the maximum relative error and regression analysis are calculated and used to assess the accuracy and relevance of pressure gradient with standard for the pressure difference of pressure transducer measurements. Results The pressure gradient calculated by direct acceleration has smaller error and higher accuracy than that calculated by velocity derivative at two spatial resolution: at d x=0.63 mm d f=0.84 and 1.32, εmax=13.9% and 21.2% for acceleration calculating and velocity derivative calculating, respectively at d x=0.89 mm d f=1.33 and 1.60, εmax=29.4% and 33.2% for acceleration calculating and velocity derivative calculating, respectively. Spatial resolution has significant influence on the calculation of pressure gradient: linear regression analysis of results from acceleration calculating, k=0.72 and 0.51, R2=0.97 and 0.91 at d x=0.63 mm and 0.89 mm, respectively for results from velocity calculating, k=0.62 and 0.44, R2=0.91 and 0.72 at d x=0.63 mm and 0.89 mm, respectively. Conclusion It has the great potential that pressure gradient is reconstructed by four-dimensional magnetic resonance blood flow acceleration mapping. It provides more accurate of pressure gradient calculating than that velocity derivative calculating. In addition, the errors decrease with increasing spatial sampling.

    四维磁共振血流加速度成像压力梯度空间分辨率加速度成像

      原文链接:
    • 万方数据

    靶向调控CTNNB1表达水平对胃癌细胞系SGC-7901增殖及侵袭能力的影响

    卢宏霞张宇涛赵善斌杨牡丹...
    248-254页
    查看更多>>摘要：目的 探讨调控Wnt/CTNNB1通路对胃癌增殖和侵袭能力的影响。 方法 人胃癌细胞系SGC-7901，体外培养慢病毒转染的稳转SGC-7901，分成CTNNB1-shRNA组、shRNA组与对照组。qRT-PCR和免疫印迹检测稳转细胞系中AKT、CTNNB1、Wnt2、Cyp19A1的表达，CCK-8测定不同细胞系增殖能力，划痕试验测定胃癌细胞系的转移能力，Transwell小室测定胃癌细胞系侵袭能力，集落形成试验测定胃癌细胞系的集落形成能力。 结果 AKT、CTNNB1、Wnt2、Cyp19A1 mRNA和蛋白在CTNNB1-shRNA组表达最低（P<0.05），在shRNA组和对照组中表达差异无统计学意义（P>0.05）；24、48、72 h细胞增殖水平在CTNNB1-shRNA组细胞最低（P<0.05），shRNA组和对照组细胞增殖差异无统计学意义（P>0.05）；划痕后24 h CTNNB1-shRNA组24 h迁移细胞率最低（P<0.05），shRNA组与对照组迁移细胞率差异无统计意义（P>0.05）；CTNNB1-shRNA组侵袭细胞数量和集落形成数量最低（P<0.05），shRNA组与对照组侵袭细胞数量差异无统计意义（P>0.05）。 结论 通过下调Wnt/CTNNB1通路能引起该通路相关下游因子在胃癌细胞中低表达，从而影响胃癌增殖和侵袭能力，有望成为胃癌治疗新靶点。 Objective To investigate the effect of regulating the Wnt/CTNNB1 pathway on proliferation and invasion of gastric cancer. Methods Human gastric cancer cell line SGC-7901 was used in this study. The SGC-7901 were cultured in vitro, stably-transfected with lentivirus, and divided into the CTNNB1-shRNA group, shRNA group and control group. qRT-PCR and Western blotting were used to detect the expression of AKT, CTNNB1, Wnt2 and Cyp19A1 in the stably transfected cell line. CCK-8 assay was used to examine the proliferation ability of different cell groups. Scratch test was used to assess the migration ability of gastric cancer cell lines. Transwell chamber assay was used to measure the invasion of gastric cancer cell lines. Capacity, colony-forming assays determine the colony-forming capability of gastric cancer cell lines. Results The mRNA and protein expression levels of AKT, CTNNB1, Wnt2, and Cyp19A1 were the lowest in the CTNNB1-shRNA group (P<0.05), and did not differ significantly between the shRNA group and control group (P>0.05). At 24, 48, and 72 h, the cell proliferation level was the lowest in the CTNNB1-shRNA group (P<0.05), and did not differ significantly between the shRNA group and the control group (P>0.05) either. At 24 h post-scratching, the 24 h migration rate was the lowest in the CTNNB1-shRNA group (P<0.05), and did not differ between the shRNA group and the control group (P>0.05) the CTNNB1-shRNA group showed lowest cell migration and colony formation (P<0.05). The number of migrating cells did not differ significantly between the shRNA group and the control group (P>0.05) . Conclusion Down-regulating the Wnt/CTNNB1 pathway can lead to low expression of downstream signaling molecules of this pathway in gastric cancer cell lines and hence interference with proliferation and invasion of gastric cancer. This offers clue to new target for treatment of gastric cancer.

    胃肿瘤细胞增殖肿瘤侵润Wnt/CTNNB1通路

      原文链接:
    • 万方数据

    斑点追踪技术联合血清高敏肌钙蛋白测定评价胃肠癌化疗患者心脏功能的改变

    徐连娣郭艳杰陈延涛刘亭亭...
    255-260页
    查看更多>>摘要：目的 应用斑点追踪技术联合血清高敏肌钙蛋白测定评价胃肠癌患者应用FOLFOX （5-氟尿嘧啶+奥沙利铂+亚叶酸钙）化疗前后的心脏功能损伤情况。 方法 选取30例健康志愿者为正常组，另选择2020年1月至2021年3月我院收治的采用FOLFOX方案进行化疗的38例胃肠癌患者作为研究对象，采用自身对照的方式进行研究，于化疗前、化疗第2、4、6个周期结束后用斑点追踪评价患者的左心室纵向心肌应变，并于化疗前、化疗第2、4、6个周期结束后（24~48 h内）分别进行高敏肌钙蛋白的测定。 结果 化疗开始后，患者LVEDV在第4、6周期结束后有明显降低，分别为（92.45±10.11）ml、（74.86±10.07）ml；LVEF在第4、6周期结束后有明显降低，分别为（61.50±1.14）%、（58.36±1.08）%，较化疗前有统计学意义（P<0.05）；LVFS在第4、6周期结束后有明显降低，分别为（37.50±2.25）%、（36.19±2.16）%，较化疗前有统计学意义（P<0.05）；而其他常规左室超声心动图参数变化不明显；患者左室收缩期纵向应变在化疗前、化疗2周期、4周期、6周期后分别为（21.42±1.63）%、（19.76±1.41）%、（18.31±1.27）%、（17.69±1.09）%，随着化疗周期的增加纵向应变降低幅度更加明显（P<0.05）；化疗第2、4、6个周期结束后患者高敏肌钙蛋白依次升高，分别为（4.04±0.77）pg/ml、（5.73±0.83）pg/ml、（7.69±0.89）pg/ml，较化疗前（2.67±0.64）pg/ml比较有统计学意义（P<0.05）。肌钙蛋白与左心室整体纵向应变呈负相关（r=-0.535，P<0.05）。 结论 斑点追踪技术联合血清高敏肌钙蛋白测定能够在胃肠癌化疗患者EF出现改变前预测患者心肌功能受损情况，并且血清高敏肌钙蛋白随着左心室整体纵向应变的降低而升高，对临床有一定的指导意义。 Objective To evaluate the damage of cardiac function in patients with gastrointestinal cancer before and after FOLFOX (5-fluorouracil + oxaliplatin + calcium folinate) chemotherapy. Methods 30 healthy people were selected as normal group. 38 patients with gastrointestinal cancer treated with FOLFOX regimen in our hospital from January 2020 to March 2021 were selected as the research object. The study was carried out in a self-control way. After the second, fourth and sixth cycles of chemotherapy, the myocardial strain of the patients was evaluated by speckle tracking. After the second, fourth and sixth cycles of chemotherapy, serum hypersensitive troponin (hs-CTNI) testing were applied. Results After chemotherapy, LVEDV was significantly decreased at the end of the 4th and 6th cycles (92.45±10.11 ml and 74.86±10.07 ml, respectively) LVEF was significantly decreased at the end of the 4th and 6th cycles (61.50±1.14 % and 58.36±1.08 %, respectively) LVFS was significantly decreased at the end of the 4th and 6th cycles (37.50±2.25 %, 36.19±2.16 %, respectively) compared with that before chemotherapy (P<0.05). Other conventional left ventricular echocardiography parameters did not change significantly. The longitudinal strain of left ventricular systole (GLS) was (21.42±1.63) %, (19.76±1.41) %, (18.31±1.27) % and (17.69±1.09) % before chemotherapy, after 2 cycles, 4 cycles and 6 cycles of chemotherapy, respectively. The longitudinal strain decreased more significantly with the increase of chemotherapy cycles (P<0.05). After the second, fourth and sixth cycles of chemotherapy, the hypersensitive trhypersensitiveoponin of patients increased successively, which were (4.04±0.77) pg/ml, (5.73±0.83) pg/ml and (7.69±0.89) pg/ml, respectively, compared with (2.67±0.64) pg/ml before chemotherapy (P<0.05). The hypersensitive troponin was negatively correlated with the global longitudinal strain of left ventricle (r=-0.535, P<0.05) . Conclusions Speck tracking combined with serum hypersensitive troponin measurement can predict the impaired myocardial function of patients with gastrointestinal cancer chemotherapy before the change of EF, and the high-sensitivity troponin increased with the decrease of the overall longitudinal strain of the left ventricle. which has certain guiding significance for clinical practice.

    斑点追踪技术胃肠癌化疗高敏肌钙蛋白心脏功能

      原文链接:
    • 万方数据

    动态增强磁共振成像参考区域模型结合表观扩散系数直方图对Luminal型乳腺癌的诊断效能

    孙好凯李国超安波刘浩...
    261-267页
    查看更多>>摘要：目的 研究动态增强磁共振成像（DCE-MRI）参考区域模型结合表观扩散系数（ADC）直方图对Luminal型乳腺癌的诊断效能。 方法 选取我院于2019年1月至2021年12月收治的96例Luminal型乳腺癌患者，均行3.0 T DCE-MRI检测、MR常规扫描以及扩散加权成像（DWI）扫描。利用GEAW 4.6后处理工作站分析b值为200、500、1000 s/mm2时的ADC直方图，记录ADC相关参数（ADCmin、ADCmean、偏度、峰度）、灌注参数[速率常数（Kep）、容量转移常数（Ktrans）]。根据乳腺癌分型分为A型、B型，比较各组间参数差异，采用Pearson分析参数间的相关性，并采用受试者工作特征（ROC）曲线分析灌注参数联合ADC值对Luminal型乳腺癌分型的诊断价值。 结果 Luminal A型乳腺癌34例，Luminal B型乳腺癌62例。A型患者的Ktrans明显低于B型（P<0.05），而Kep值差异无统计学意义（P>0.05）。b值为200、500、1000 s/mm2时，患者的ADCmean、峰度差异无统计意义（P>0.05），其中b值为1000 s/mm2时，A型患者的ADCmin、偏度均明显高于B型患者（P<0.05）。Pearson相关性分析显示，Ktrans与ADCmin、偏度呈负相关性（b=1000 s/mm2），r分别为-0.545、-0.528，均P<0.05。Ktrans、ADCmin、偏度鉴别Luminal乳腺癌分型的AUC分别为0.799（95%CI：0.706~0.892）、0.832（95%CI：0.753~0.911）、0.721（95%CI：0.614~0.827）。三指标联合诊断的AUC为0.887（95%CI：0.813~0.960），明显高于单独检测（P<0.001）。 结论 b值为1000 s/mm2时的ADC值（ADCmin、偏度）与DCE-MRI的定量参数（Ktrans）具有负相关性，两者联合检测对Luminal型乳腺癌的分型较高的诊断价值。 Objective To study the diagnostic efficiency of Dynamic enhanced magnetic resonance imaging (DCE-MRI) reference region model combined with apparent diffusion coefficient (ADC) histogram in the diagnosis of Luminal breast cancer. Methods 96 patients with Luminal breast cancer in our hospital from January 2019 to December 2021 were selected. All patients underwent 3.0 T DCE-MRI, conventional MR scan and DWI scan. The ADC histogram with b value of 200, 500 and 1000 s/mm2 were analyzed by GEAW 4.6 post-processing workstation. ADC related parameters (adcmin, adcmean, skewness, kurtosis) and perfusion parameters (kep, Ktrans) were recorded. According to the classification of breast cancer, they were divided into type A and type B, and the differences of parameters among the groups were compared. The correlation between parameters was analyzed by Pearson, and ROC curve was used to analyze the diagnostic value of perfusion parameters combined with ADC value in the classification of Luminal breast cancer. Results There were 34 cases of Luminal a breast cancer and 62 cases Luminal B breast cancer. Ktrans of type A was significantly lower than that of type B (P<0.05), but there was no significant difference in kep (P>0.05). When the b value were 200, 500 and 1000 s/mm2, the difference in ADCmean and kurtosis of patients is not statistically significant (P>0.05). When the b value was 1000 s/mm2, the ADCmin and skewness of type A patients are significantly higher In type B patients (P<0.05). Pearson correlation analysis showed that Ktrans was negatively correlated with adcmin and skewness (b=1000 s/mm2), r=-0.545, -0.528, P<0.05. The AUC of Ktrans, adcmin and skewness were 0.799 (95%CI: 0.706-0.892), 0.832 (95%CI: 0.753-0.911), 0.721 (95%CI: 0.614-0.827), respectively. The AUC of combined diagnosis was 0.887 (95%CI: 0.813-0.960), which was significantly higher than that of single detection (P<0.001) . Conclusion The ADC values (ADCmin, skewness) at the b value of 1000 s/mm2 were negatively correlated with the quantitative parameters (Ktrans) of DCE-MRI. The combined detection of the two has high diagnostic value for the classification of Luminal breast cancer.

    动态增强磁共振成像表观扩散系数乳腺癌扩散加权成像

      原文链接:
    • 万方数据

    微RNA-221、微RNA-182-5p及肿瘤坏死因子-α对肺炎支原体感染患儿伴气道高反应的预测价值

    屈春燕张凡王娜袁城城...
    268-273页
    查看更多>>摘要：目的 探讨微RNA（miR）-221、miR-182-5p及肿瘤坏死因子-α（TNF-α）对肺炎支原体（MP）感染患儿气道高反应性（AHR）的预测价值。 方法 选取2020年1月至2022年12月我院儿科收治的328例MP感染患儿为研究对象，并按患儿是否伴发AHR分成AHR组（n=118）和非AHR组（n=210）。检测两组的miR-221、miR-182-5p及TNF-α水平，并获取相关临床资料，分析MP感染患儿发生AHR的危险因素，受试者工作特征曲线（ROC）评估miR-221、miR-182-5p及TNF-α对MP感染患儿发生AHR的预测价值。 结果 Logistic分析显示，病程、家族哮喘史、FEV1、FVC、miR-221、miR-182-5p及TNF-α水平均是MP感染患儿发生AHR的独立危险因素（P<0.05）。ROC曲线显示，miR-221、miR-182-5p及TNF-α水平单独及联合预测MP感染患儿发生AHR的AUC分别为0.756、0.861、0.618、0.899，三者联合预测MP感染患儿发生AHR的AUC高于单独预测（P<0.05）。 结论 miR-221、miR-182-5p及TNF-α是MP感染患儿发生AHR的独立危险因素，miR-221、miR-182-5p及TNF-α水平对MP感染患儿发生AHR均具有一定预测价值，三者联合预测时价值更高。 Objective To investigate the predictive value of microRNA-221 (miR-221), miR-182-5p and tumor necrosis factor-α (TNF-α) on airway hyperresponsiveness (AHR) in children with Mycoplasma pneumoniae (MP) infection. Methods 328 children with MP infection admitted to our hospital from January 2020 to December 2022 were selected as the study object, and the children were divided into AHR group (n=118) and non-AHR group (n=210) according to whether they had AHR with or without AHR.To detect miR-221, miR-182-5p and TNF-α levels in both groups and obtain relevant clinical information to analyze the risk factors for the development of AHR in children with MP infection. and the subject operating characteristic curve (ROC) was used to assess the predictive value of miR-221, miR-182-5p and TNF-α for the development of AHR in children with MP infection. Results Logistic analysis showed, family history of asthma, FEV1, FVC, miR-221, miR-182-5p and TNF-α levels were all independent risk factors for the development of AHR in MP-infected children (P<0.05). The ROC curves showed that the AUC of miR-221, miR-182-5p and TNF-α levels alone and in combination predicted the occurrence of AHR in MP-infected children was 0.756, 0.861, 0.618 and 0.899, respectively, and the AUC of MP infection was higher than that of MP infection alone (P<0.05) . Conclusions miR-221, miR-182-5p and TNF-α are independent risk factors for the development of AHR in MP-infected children. miR-221, miR-182-5p and TNF-α levels have some predictive value for the development of AHR in MP-infected children, and the value is higher when the three are combined.

    微RNA-221微RNA-182-5p肿瘤坏死因子-α肺炎支原体气道高反应

      原文链接:
    • 万方数据

    胸椎旁神经阻滞对肺癌患者术后镇痛及血流动力学的影响

    陈刚李争卫孙勇
    274-279页
    查看更多>>摘要：目的 探讨胸椎旁神经阻滞对肺癌全麻术后镇痛及血流动力学的影响。 方法 收集2017年1月至2019年12月本院收治的肺癌患者126例，均行全身麻醉下胸腔镜肺癌根治术。随机数字表法将患者分为对照组和研究组，每组63例，分别行全身麻醉、麻醉诱导前胸椎旁神经阻滞联合全身麻醉。比较两组术后不良反应、术后住院时间、舒芬太尼用量。比较两组不同时点的疼痛程度，比较两组患者的应激状态和血流动力学指标。 结果 研究组术后不良反应发生率、术后住院时间、舒芬太尼用量均低于对照组（均P<0.05）。术后2 h、6 h、12 h、1 d、2 d研究组VAS评分较对照组均显著降低（均P<0.05）。与术前相比，术后2 h两组患者血清肾上腺素（E）、去甲肾上腺素（NE）、血管紧张素Ⅱ（AngⅡ）等各项应激状态指标均升高（均P<0.05）；与同时点对照组相比，术后2 h研究组血清E、NE、AngII水平均降低（均P<0.05）。气管插管后、切皮后5 min，对照组心率（HR）、平均动脉压（MAP）均较入室时降低，拔管时高于入室时（均P<0.05）；切皮后5 min研究组HR、MAP均较入室时降低（均P<0.05），气管插管后、拔管时研究组HR、MAP与入室时比较，差异无统计学意义（均P>0.05）。气管插管后、切皮后5 min研究组HR、MAP均高于对照组，拔管时均低于对照组（均P<0.05）。 结论 肺癌全麻手术患者麻醉诱导前行胸椎旁神经阻滞能够减少舒芬太尼用量及不良反应，减轻应激反应，有利于维持术中血流动力学稳定。 Objective To investigate the effect of thoracic paravertebral nerve block on postoperative analgesia and hemodynamics in patients with lung cancer under general anesthesia. Methods A total of 126 patients with lung cancer admitted to our hospital from January 2017 to December 2019 were collected. All patients underwent thoracoscopic radical resection of lung cancer under general anesthesia. The patients were divided into control group and study group by random number table method with 63 cases in each group, and general anesthesia or pre-anesthesia induction of thoracic paravertebral nerve block combined with general anesthesia were performed respectively. The postoperative adverse reactions, postoperative hospitalization stay and sufentanil dosage were compared between the two groups. The pain degree of the two groups at different time points was compared, and the stress state and hemodynamic indexes of the two groups were compared. Results The incidence of postoperative adverse reactions, postoperative hospital stay and dosage of sufentanil in the study group were lower than those in the control group (all P<0.05). The VAS scores of the study group were significantly lower than those of the control group at 2 h, 6 h, 12 h, 1 d and 2 d after operation (allP<0.05). Compared with those before operation, the levels of serum epinephrine (E), norepinephrine (NE), angiotensinⅡ (AngⅡ) and other stress indexes were increased in both groups at 2 h after operation (allP<0.05). Compared with the control group at the same time point, the levels of serum E, NE and AngⅡ in the study group decreased at 2 h after operation (allP<0.05). After tracheal intubation and 5 min after skin incision, the heart rate (HR) and mean arterial pressure (MAP) of the control group were lower, while those at extubation were higher than those at the time of entry (allP<0.05). Five min after skin incision, HR and MAP in the study group were lower than those at the time of entry (bothP<0.05). There was no significant difference in HR and MAP between the study group after tracheal intubation, at extubation and at the time of entry (bothP>0.05). After tracheal intubation and 5 min after skin incision, HR and MAP in the study group were higher than those in the control group, and lower than those in the control group at extubation (allP<0.05) . Conclusion Thoracic paravertebral nerve block before anesthesia induction in patients with lung cancer undergoing general anesthesia can reduce the dosage of sufentanil and adverse reactions, reduce stress response, and help to maintain intraoperative hemodynamic stability.

    胸椎旁神经阻滞肺肿瘤舒芬太尼应激状态镇痛泵

      原文链接:
    • 万方数据

    MOTOmed智能运动训练系统对COPD患者肺康复的影响

    吕海鹏徐卫方孙勇
    280-285页
    查看更多>>摘要：目的 探讨MOTOmed智能运动训练系统对慢性阻塞性肺疾病（COPD）患者肺康复的影响。 方法 收集2021年2月至2022年2月本院收治的COPD患者100例，随机数字表法分为对照组与观察组，每组50例。对照组行常规肺康复治疗，观察组在常规肺康复治疗基础上进行MOTOmed智能运动训练系统干预治疗，均持续3个月。治疗前、治疗后3个月测定2组患者肺功能，包括第1秒用力呼气容积/用力呼气量（FEV1/FVC）、FEV1、最大呼气中段流速（MMEF）；比较2组血气指标，包括动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）；比较2组患者运动能力及生活质量，包括6 min步行试验（6-WMT）、简易躯体能力测试（SPPB）和圣乔治呼吸问卷（SGRQ）评分。 结果 治疗前2组患者肺功能、血气指标、运动能力及SGRQ评分差异均无统计学意义（均P>0.05）。治疗后3个月观察组FEV1、FEV1/FVC、MMEF、PaO2、6-WMT、SPPB均较对照组显著升高，PaCO2、运动能力、生活质量评分均较对照组显著降低（均P<0.05）。 结论 MOTOmed智能运动训练系统能明显改善COPD患者肺功能及血气指标，增强运动能力，提升生活质量。 Objective To explore the effect of MOTOmed intelligent exercise training system on pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) . Methods A total of 100 patients with COPD admitted to our hospital from February 2021 to February 2022 were collected and randomly divided into control group and observation group, with 50 cases in each group. The control group received routine pulmonary rehabilitation, and the observation group was treated with MOTOmed intelligent exercise training system intervention on the basis of routine pulmonary rehabilitation for 3 months. Pulmonary function, including forced expiratory volume in one second/forced expiratory volume (FEV1/FVC), FEV1 and maximum mid-expiratory flow (MMEF) were measured before and 3 months after treatment. The blood gas indexes including arterial partial pressure of oxygen (PaO2) and arterial partial pressure of carbon dioxide (PaCO2) were compared between the two groups. The exercise capacity and quality of life were compared between the two groups, including 6-minute walking test (6-WMT), Short Physical Performance Battery (SPPB) test and St. George's Respiratory Questionnaire (SGRQ) . Results There was no significant difference in lung function, blood gas index, exercise capacity and SGRQ score between the two groups before treatment (all P>0.05). Three months after treatment, FEV1, FEV1/FVC, MMEF, PaO2, 6-WMT and SPPB scores in the observation group were significantly higher than those in the control group, while PaCO2, exercise capacity and quality of life scores were significantly lower than those in the control group (all P<0.05) . Conclusion MOTOmed intelligent exercise training system can significantly improve lung function and blood gas index of COPD patients, enhance exercise capacity and improve the quality of life.

    肺疾病,慢性阻塞性智能运动训练系统肺功能简易躯体能力测试生活质量

      原文链接:
    • 万方数据

    达格列净与利拉鲁肽治疗成人2型糖尿病早期肾病的疗效比较

    张沥陈海滨谢环宋俊华...
    286-291页
    查看更多>>摘要：目的 探讨达格列净与利拉鲁肽治疗成人2型糖尿病（T2DM）早期肾病的疗效及安全性。 方法 收集2021年1月至11月本院收治的成人T2DM早期肾病患者90例，随机分为对照组、利拉鲁肽组、达格列净组，每组30例。对照组采用常规降糖治疗，利拉鲁肽组和达格列净组分别加用利拉鲁肽、达格列净，均持续治疗12周。比较各组治疗前后血糖、体质量指数（BMI）、肾功能和不良反应发生情况。 结果 治疗前3组空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c）比较，差异均无统计学意义（均P>0.05）。治疗后12周，3组FPG、2hPG、HbA1c均较治疗前下降，且利拉鲁肽组FPG高于对照组、2hPG低于对照组；达格列净组FPG低于利拉鲁肽组、2hPG高于利拉鲁肽组（均P<0.05）。治疗前、治疗后12周3组BMI比较，差异均无统计学意义（均P>0.05）。治疗前3组血肌酐、尿素氮、尿酸、估算肾小球滤过率（eGFR）、尿微量白蛋白、尿白蛋白肌酐比组间比较，差异均无统计学意义（均P>0.05）。治疗后12周达格列净组尿白蛋白肌酐比较治疗前降低，尿素氮、尿肌酐高于对照组（均P<0.05）。利拉鲁肽组消化道不良反应发生率高于对照组及达格列净组（均P<0.05）。 结论 相较于利拉鲁肽，达格列净治疗成人T2DM早期肾病的降血糖作用更加明显，安全性肯定，整体耐受性好。 Objective To investigate the efficacy and safety of dapagliflozin and liraglutide in the treatment of adult type 2 diabetes mellitus (T2DM) patients with early nephropathy. Methods From January to November 2021, 90 adult patients with T2DM early nephropathy admitted to our hospital were collected and randomly divided into control group, liraglutide group and dapagliflozin group, with 30 cases in each group. The control group received conventional hypoglycemic therapy, and the liraglutide group and dapagliflozin group were treated with liraglutide and dapagliflozin, respectively, for 12 weeks. Blood glucose, body mass index (BMI), renal function and adverse reactions in each group were compared before and after treatment. Results There was no significant difference in fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbA1c) among the three groups before treatment (all P>0.05). After 12 weeks of treatment, FPG, 2hPG and HbA1c in the three groups were lower than those before treatment, and FPG in the liraglutide group was higher than that in the control group, and 2hPG was lower than that in the control group FPG in dapagliflozin group was lower than that in liraglutide group, and 2hPG was higher than that in liraglutide group (allP<0.05). There was no significant difference in BMI among the three groups before and 12 weeks after treatment (allP>0.05). There was no significant difference in serum creatinine, urea nitrogen, uric acid, estimated glomerular filtration rate (eGFR), urinary microalbumin and urinary albumin creatinine ratio among the three groups before treatment (allP>0.05). After 12 weeks of treatment, the urinary albumin creatinine ratio in the dapagliflozin group was lower than that before treatment, and the urea nitrogen and urinary creatinine were higher than those in the control group (allP<0.05). The incidence of gastrointestinal adverse reactions in the liraglutide group was higher than those in the control group and the dapagliflozin group (bothP<0.05) . Conclusion Compared with liraglutide, dapagliflozin has a more obvious hypoglycemic effect in the treatment of early nephropathy in adult T2DM, with definite safety and good overall tolerance.

    糖尿病,2型糖尿病肾病达格列净利拉鲁肽血糖肾功能

      原文链接:
    • 万方数据

    256排宽体探测器CT与CT血管造影扫描结合"双低"在主动脉夹层患者分型诊断中的价值研究

    安波于国政张俊勇张翔...
    292-295页
    查看更多>>摘要：研究256排宽体探测器计算机断层扫描（CT）与CT血管造影（CTA）扫描结合"双低"在主动脉夹层（AD）患者分型诊断中的价值。研究发现双低组患者在冠状动脉各节段的信噪比（SNR）、图像优良指数（FOM）以及右冠状动脉对比信噪比（CNR）明显高于常规组，剂量长度乘积（DLP）、容积CT剂量指数（CTDIvol）、有效辐射剂量（ED ssde）、总碘量以及碘注入率均明显低于常规组，特异性以及准确率高于常规检查（P<0.05）。256排宽体探测器CT与CTA扫描结合"双低"可准确诊断AD分型，且在降低辐射剂量的同时保证了图片质量，便于临床诊断。 To investigate the value of 256 row wide body detector computed tomography (CT) combined with CT angiography (CTA) scanning in the diagnosis of aortic dissection (AD) patients with "double low" classification. The signal-to-noise ratio (SNR) and figure of merit (FOM) of each segment of coronary artery and the contrast signal to noise ratio (CNR) of right coronary artery in the double low group were significantly higher than those in the conventional group. dose-length product (DLP), CT dose index volume (CTDIvol), effective dose ssde (ED ssde), total iodine content and iodine injection rate were significantly lower than those in conventional group, and the sensitivity, specificity and accuracy were higher than those in conventional group ( P<0.05). 256-row wide-body detector CT and CTA scan combined with "double low" can accurately diagnose AD type, and can reduce radiation dose while ensuring picture quality, which is convenient for clinical diagnosis and analysis.

    主动脉夹层CT血管成像对比剂分型

      原文链接:
    • 万方数据

    基于SEER数据库的神经内分泌宫颈癌临床特征及预后分析

    王隽方岳雨张翔
    296-301页
    查看更多>>摘要：探讨神经内分泌宫颈癌（NECC）的临床特征及相关预后因素。分析SEER数据库NECC患者的临床信息，发现NECC预后差，年龄≤50岁、接受手术与放化疗，TNM分期早的小细胞类型神经内分泌宫颈癌预后较好，肿瘤分化程度不是NECC的独立预后因素。 To investigate the clinical characteristics and prognostic factors associated with neuroendocrine cervical cancer (NECC). The clinical informations of NECC patients diagnosed in the SEER database were analysed. The prognosis of NECC is poor, and the prognosis of small-cell-type NECC patients with age ≤50 years, receiving surgery and radiotherapy, or at early TNM stage is better. The degree of tumor differentiation is not an independent prognostic factor of NECC.

    神经内分泌宫颈癌临床特征生存分析预后因素

      原文链接:
    • 万方数据