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药物分析学报（英文）
西安交通大学
药物分析学报（英文）

西安交通大学

双月刊

2095-1779

jpa2011@126.com

029-82655433

710061

西安市雁塔西路76号

药物分析学报（英文）/Journal Journal of Pharmaceutical AnalysisCSCD北大核心SCI
查看更多>>《药物分析学报（英文）》（Journal of Pharmaceutical Analysis，简称JPA），2011年创刊，双月刊，为大16开本，系教育部主管、西安交通大学主办的药物分析专业英文期刊。JPA以搭建高水平的国际学术交流平台、创办具有国际影响力的高水平的专业学术期刊为办刊宗旨。主要报道药物分析新方法、新技术，药品质量控制和用药安全等最新研究成果。创刊之初与Elsevier国际出版集团合作，已组建国际化编委会，采用EVISE投稿审稿系统，开放获取，通过ScienceDirect平台在线向全球读者开放阅读，实现稿源国际化、同行评议国际化、出版国际化和读者国际化。
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    Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

    Guiqin YeXin SunJiuzhou LiYuanyuan Mai...
    914-925页
    查看更多>>摘要：Lung cancer ranks the top of malignancies that cause cancer-related deaths worldwide.The leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory diseases.Our previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully elucidated.We synthesized Moracin N(MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic analysis.MAN and its probe exerted similar growth-inhibitory effect on human lung cancer cells.Chemical proteomic results showed that MAN targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCR)signaling pathway,indicating its immune-regulatory function.Cell-free surface plasmon resonance(SPR)results showed the direct interaction of MAN with PD-L1 protein.Molecular docking analysis demonstrated that MAN bound to E158 residue of PD-L1 protein.MAN downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMR).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAN-treated A549 cells,resulting in the increase of CD8+GZMB+T cells and the decrease of CD8+PD-1+T cells.It suggested that MAN exerts anti-cancer effect through blocking the PD-L1/PD-1 signaling.In vivo,MAN combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic effect.Taken together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung cancer.Their modulatory effect on tumor microenvironment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.
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    Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

    Shiyu ChenYuxuan LiYingrui ZhangHongren Yao...
    926-929页
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    Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

    Xiao-lan LiJian-qing ZhangYun LiXuan-jing Shen...
    930-932页
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    Call for Papers for Special Issue Innovative Pharmaceutical Research Facilitated by AI

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