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中华地方病学杂志
中国疾病预防控制中心地方病控制中心
中华地方病学杂志

中国疾病预防控制中心地方病控制中心

孙殿军

双月刊

2095-4255

cje2005@163.com

0451-86675924

150081

黑龙江省哈尔滨市南岗区保健路157号

中华地方病学杂志/Journal Chinese Journal of EndemiologyCSCD北大核心CSTPCD
查看更多>>中华医学会、哈尔滨医科大学主办。本刊主要报道克山病、大骨节病、碘缺乏病、地方性氟、砷中毒、鼠疫、布鲁杆菌病、寄生虫等疾病的研究成果。主要栏目:述评、综述、专家论坛、论著、现场调查、临床医学、检测方法、卫生管理、学术争鸣、防治经验等。《中国地方病学杂志》被美国《化学文摘》、荷兰《医学文摘》、美国《剑桥科学文摘》和波兰《哥伯尼索引》收录;是中国自然科学、中国生物医学核心期刊,预防医学、卫生学类核心期刊。2008年获中华医学会优秀期刊二等奖,2010年获中华医学会优秀期刊奖。
正式出版
收录年代

    2017 - 2021年山东省滕州市儿童及孕妇碘营养状况调查分析

    裴宝伟徐玉銮张祎祎
    61-65页
    查看更多>>摘要:目的 掌握山东省滕州市重点人群碘营养状况,为今后碘缺乏病防治工作提供科学依据。 方法 2017 - 2021年,采用分层整群抽样方法,每年在滕州市的21个碘缺乏病镇(街道)按东、西、南、北、中划分5个抽样片区,每个片区抽取1个镇(街道)为监测点;每个镇(街道)抽取1所小学的40名8 ~ 10岁非寄宿学生(男女各半、年龄均衡)及20名孕妇(孕早、中、晚期均衡),采集家中食用盐盐样和随意1次尿样进行盐碘及尿碘含量检测。 结果 共采集家中食用盐盐样1 506份,盐碘中位数为24.29 mg/kg,碘盐覆盖率为96.55%(1 454/ 1 506),碘盐合格率为93.40%(1 358/1 454),合格碘盐食用率为90.17%(1 358/1 506);不同年份盐碘中位数、碘盐覆盖率比较,差异均有统计学意义(H = 119.61,P < 0.001;χ 2 = 14.53,P = 0.006)。共采集8 ~ 10岁儿童尿样1 000份,尿碘中位数为182.20 μg/L,不同年份、性别、年龄及城乡儿童尿碘中位数比较,差异均有统计学意义(H = 38.18、13.96、49.30、8.34,均P < 0.05)。共采集孕妇尿样499份,尿碘中位数为152.40 μg/L,不同年份间比较,差异有统计学意义( H = 20.09,P < 0.001)。 结论 滕州市儿童和孕妇碘营养均处于适宜水平;但合格盐碘食用率、孕妇尿碘水平均处于标准下限,且存在波动,有碘缺乏风险。相关部门应重点加强碘盐管理、重点人群碘缺乏监测和健康教育工作,做到科学补碘、持续稳定碘营养适宜状态。 Objective To investigate the iodine nutrition status of key populations in Tengzhou City, Shandong Province, and provide a scientific basis for prevention and control of iodine deficiency disorders in the future. Methods From 2017 to 2021, a stratified cluster sampling method was adopted, 21 iodine deficiency disorders towns (streets) in Tengzhou City were divided into 5 sampling areas based on east, west, south, north, and center, with 1 town (street) selected as the monitoring site from each area every year 40-non boarding students aged 8 - 10 (half male and half famale, age balanced) from one primary school and 20 pregnant women (early, middle, late pregnancy balanced) were selected from each town (street), and their household salt and urine samples were collected for test of salt iodine and urine iodine contents. Results A total of 1 506 household salt samples were collected, the median salt iodine was 24.29 mg/kg, the coverage rate of iodized salt was 96.55% (1 454/ 1 506), the qualified rate of iodized salt was 93.40% (1 358/1 454), and the consumption rate of qualified iodized salt was 90.17% (1 358/1 506). There were statistically significant differences in the median salt iodine and coverage rate of iodized salt among different years (H = 119.61, P < 0.001 χ 2 = 14.53, P = 0.006). A total of 1 000 urine samples were collected from children aged 8 - 10, with a median urine iodine of 182.20 μg/L. The differences in urine iodine between different years, genders, ages, and urban and rural children were statistically significant ( H = 38.18, 13.96, 49.30, 8.34, P < 0.05). A total of 499 urine samples were collected from pregnant women, with a median urine iodine of 152.40 μg/L. There were statistically significant differences in the median urine iodine of pregnant women in different years ( H = 20.09, P < 0.001). Conclusions The iodine nutrition of children and pregnant women in Tengzhou City is at an appropriate level. However, the consumption rate of qualified salt iodine and the urine iodine level of pregnant women are at the lower limit of the standard, and there are fluctuations, posing a risk of iodine deficiency. Relevant departments should focus on strengthening the management of iodized salt, monitoring iodine deficiency among key populations, and providing health education to achieve scientific iodine supplementation and sustained stable iodine nutrition suitability.

    盐类尿儿童孕妇

    青海省大骨节病病区成人血清α2-巨球蛋白检测结果分析

    李强周昕王建玲李积权...
    66-67页
    查看更多>>摘要:大骨节病(KBD)是一种慢性、地方性、变形性骨关节病,其病因尚不明确。青海省成人KBD患者分布相对集中,开展相关KBD防治研究工作,将为KBD的精准医疗提供科学依据[1]。α2-巨球蛋白(α2-M)是一种广谱蛋白酶抑制剂,对多种蛋白水解酶都有抑制作用,补充α2-M可减轻软骨损伤,抑制分解代谢因子基质金属蛋白酶-13(MMP-13)的表达,同时增强软骨基质Ⅱ型胶原和蛋白聚糖的合成,可能对骨关节炎(OA)的发生发展产生影响[2]。因此,本研究对青海省KBD病区成人进行血清α2-M检测,探讨其对KBD发生发展的影响,现将结果报道如下。

    大骨节病成人血清α2-巨球蛋白

    基于TaqMan-MGB荧光探针的实时荧光PCR法检测玉树藏族自治州鼠疫耶尔森菌rpsL基因耐药突变

    靳娟李胜何建杨晓艳...
    68-70页
    查看更多>>摘要:鼠疫是由鼠疫耶尔森菌(以下简称鼠疫菌)引起的一种烈性传染病,发病急、传播快且病死率极高。历史上发生过3次鼠疫大流行,导致上亿人口死亡。近20年来全球鼠疫疫情呈上升趋势,2000 - 2018年,世界卫生组织(WHO)共收到来自美洲、非洲和亚洲21个国家报告的2万多起鼠疫病例[1]。我国动物间鼠疫一直较为活跃,且除个别年份外,几乎每年都有人间鼠疫发生。2019年11月,北京市首先出现2例内蒙古自治区输入性肺鼠疫病例,随后内蒙古自治区又报道2例腺鼠疫病例,提示这一甲类传染病仍对人们的生命安全具有极大的潜在威胁[2,3,4]。链霉素是WHO鼠疫手册[5]和我国《鼠疫诊疗方案(试行)》(卫办应急发[2011]第18号)[6]中治疗鼠疫的首选药物。但值得注意的是,2021年Dai等[7]发现国内1株鼠疫菌因编码核糖体蛋白S12的rpsL基因第128 bp位点的碱基发生了突变,从而产生了对链霉素的高度耐药性。为此,本研究应用基于TaqMan-MGB荧光探针的实时荧光PCR法(简称MGB荧光探针法),选取鼠疫流行较为严重的玉树藏族自治州(以下简称玉树州)鼠疫自然疫源地内分离的鼠疫菌,检测链霉素耐药位点rpsL基因第128 bp位点碱基的突变情况,判断当地菌株的耐药情况,为鼠疫疫情的防控提供参考。

    鼠疫rpsL基因耐药

    地方性氟中毒致机体损伤的研究进展

    赵凡郭志伟张祎祎
    71-76页
    查看更多>>摘要:地方性氟中毒是指生活在由自然或人为污染所致高氟环境中的居民,因体内摄入过量氟化物而引起的一种地方性疾病。氟斑牙、氟骨症是地方性氟中毒较常见的症状;此外,长期氟暴露还可引起神经系统、心血管系统、泌尿系统等多个系统的损伤,最终导致全身多器官的慢性病变和功能障碍。目前,地方性氟中毒仍是我国乃至世界的严重公共卫生问题之一。故本文从骨相和非骨相系统两方面就地方性氟中毒对人群机体损伤的研究进展进行综述,以期为今后地方性氟中毒的持续防控提供参考依据。 Endemic fluorosis refers to an endemic disease caused by excessive intake of fluoride in the body of residents living in high fluoride environment due to natural or man-made pollution. Dental fluorosis and bone fluorosis are common symptoms of endemic fluorosis. In addition, long-term exposure to fluorine can cause damage to multiple systems such as the central nervous system, cardiovascular system, urinary system, ultimately leading to chronic lesions and functional impairments of multiple organs throughout the body. At present, endemic fluorosis remains one of the serious public health problems in China and even the world. Therefore, this article reviews the research progress on the damage of endemic fluorosis to the human body from both bone and non-bone systems, in order to provide reference for the continuous prevention and control of endemic fluorosis in the future.

    机体损伤骨相系统非骨相系统

    食物中致甲状腺肿物质的作用分析

    潘皓雯解鸿蕾侯鑫赵蒙...
    77-81页
    查看更多>>摘要:甲状腺肿是一种非炎性非肿瘤性的增生肿大。多项研究表明硫氰酸盐、异硫氰酸盐等物质可以预防多种肿瘤发生,但有研究发现此类物质也会导致甲状腺肿。本文收集了食物中常见的致甲状腺肿物质的相关资料,并探讨其作用机制,为指导居民膳食健康平衡奠定基础。 Goiter is a kind of non-inflammatory and non-neoplastic hyperplasia and enlargement. Many studies have shown that substances such as thiocyanates and isothiocyanates can prevent the development of a variety of tumors. However, some studies have also found that such substances can lead to goiter. In this article, relevant information on common goitrogen in food are collected to explore their mechanism of action, laying a foundation for guiding residents to maintain a healthy and balanced diet.

    甲状腺肿食物硫氰酸盐黄酮类化合物

    甲状腺结节影响因素的研究进展

    徐利花张仲良王燕玲吴师菲...
    82-86页
    查看更多>>摘要:近年来,甲状腺疾病的检出率和发病率都呈上升趋势。甲状腺结节(TN)是一种常见的甲状腺疾病,可分为良性结节和恶性结节。遗传、体型、炎症等因素均有可能导致TN。本文对影响TN发生、发展的因素进行分析与总结,为TN的科学防治、临床研究及患者健康指导提供依据。 In recent years, the detection rate and incidence of thyroid diseases are on the rise. Thyroid nodule (TN) is a common thyroid disease that can be divided into benign nodules and malignant nodules. Genetic factors, physiqu, inflammation, and other factors can all lead to TN. In this article, the factors affecting the occurrence and development of TN were analyzed and summarized to provide a basis for scientific prevention and treatment of TN, clinical research, and patient health guidance.

    甲状腺结节影响因素

    新年寄语

    F01页
    查看更多>>摘要:瑞雪纷纷,晶露为霜,岁岁新年,今又始航。在这辞旧迎新的时刻,《中华地方病学杂志》向长期以来关心、支持本刊的各位领导、专家、学者、广大读者及地方病科研、防治工作者致以最诚挚的感谢和最美好的祝福!