期刊,中国科学:生命科学（英文版） 2024年卷2期_国家学术搜索

期刊信息/Journal information

中国科学:生命科学（英文版）

主　　编：周光召

出版周期：月刊

国际刊号：1674-7305

电子邮箱：sales@scichina.org

电　　话：010-64019820

邮政编码：100717

地　　址：北京东黄城根北街16号

中国科学:生命科学（英文版）/Journal Science China(Life Sciences)CSCDCSTPCDSCI

查看更多>>《中国科学》是中国科学院主办、中国科学杂志社出版的自然科学专业性学术刊物。《中国科学》任务是反映中国自然科学各学科中的最新科研成果，以促进国内外的学术交流。《中国科学》以论文形式报道中国基础研究和应用研究方面具有创造性的、高水平的和有重要意义的科研成果。在国际学术界，《中国科学》作为代表中国最高水平的学术刊物也受到高度重视。国际上最具有权威的检索刊物SCI，多年来一直收录《中国科学》的论文。1999年《中国科学》夺得国家期刊奖的第一名。

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Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets

Jing LiFenfen LiuKaibin MoHengjia Ni...

379-390页

查看更多>>摘要：Weaning piglets usually suffer from severe diarrhea(commonly known as postweaning diarrhea,PWD)along with intestinal motility disorder.Intestinal peristalsis is mainly regulated by the longitudinal muscle-myenteric plexus(LM-MP).To understand the relationship between intestinal LM-MP function and the development of PWD,we compared the intestinal electrical activity,and the transcriptional profile of the LM-MP between 21-day-old piglets(just weaned,n=7)and 24-day-old piglets(suffered the most severe weaning stress,n=7).The results showed that 24-day-old piglets exhibited different degrees of diarrhea.A significant increase in the slow-wave frequency in the ileum and colon was observed in 24-day-old piglets,while c-kit expression in the intestinal LM-MPs was significantly decreased,indicating that PWD caused by elevated slow-wave frequency may be associated with loss of c-kit.The real-time quantitative PCR(RT-qPCR)and enzyme-linked immunosorbent assay(ELISA)showed that intestinal LM-MPs in 24-day-old piglets may undergo inflammation and oxidative stress.Significant increases in 8-hydroxy-2'-deoxyguanosine and decreases in thioredoxin suggest that weaning may lead to DNA damage in the LM-MP of 24-day-old piglets.In addition,activating transcription factor 3 was significantly upregulated,indicating nerve damage in the LM-MP of 24-day-old piglets.The transcriptomic results showed that most of the differentially expressed genes in the ileal LM-MP after weaning were downregulated and closely related to the cell cycle process.Subsequent RT-qPCR analysis showed that the relative expression of p21 was upregulated,while the expression of cyclin A2,cyclin Bl,and proliferating cell nuclear antigen was downregulated in the ileal and colonic LM-MP of 24-day-old piglets,suggesting that weaning may inhibit cell proliferation and cause G1/S cell cycle arrest in ileal and colonic LM-MP.In conclusion,weaning may lead to cell cycle arrest by causing DNA damage in the LM-MP,impairing intestinal motility regulation,and ultimately leading to diarrhea in piglets.

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Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants

Awei ZhangHaizhen ZhangRonghua WangHongfu He...

391-402页

查看更多>>摘要：The prevention and control of rice bacterial leaf blight(BLB)disease has not yet been achieved due to the lack of effective agrochemicals and available targets.Herein,we develop a series of novel bissulfones and a novel target with a unique mechanism to address this challenge.The developed bissulfones can control Xanthomonas oryzae pv.oryzae(Xoo),and 2-(bis(methylsulfonyl)methylene)-N-(4-chlorophenyl)hy-drazine-1-carboxamide(B7)is more effective than the commercial drugs thiodiazole copper(TC)and bismerthiazol(BT).Pyruvate kinase(PYK)in Xoo has been identified for the first time as the target protein of our bissulfone B7.PYK modulates bacterial virulence via a CRP-like protein(Clp)/two-component system regulatory protein(regR)axis.The elucidation of this pathway facilitates the use of B7 to reduce PYK expression at the transcriptional level,block PYK activity at the protein level,and impair the interaction within the PYK-Clp-regR complex via competitive inhibition,thereby attenuating bacterial biology and pathogenicity.This study offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target PYK.We believe that these valuable discoveries will be used for bacterial disease control in the future.

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维普

Climate change filtered out resource-acquisitive plants in a temperate grassland in Inner Mongolia,China

Heying JingXingshuo XiongFeng JiangXucai Pu...

403-413页

查看更多>>摘要：Global climate change has led to the decline of species and functional diversity in ecosystems,changing community composition and ecosystem functions.However,we still know little about how species with different resource-use strategies(different types of resource usage and plant growth of plants as indicated by the spectrum of plant economic traits,including acquisitive resource-use strategy and con-servative resource-use strategy)would change in response to climate change,and how the changes in the diversity of species with different resource-use strategies may influence community-level productivity.Here,using long-term(1982-2017)observatory data in a temperate grassland in Inner Mongolia,we investigated how climate change had affected the species richness(SR)and functional richness(FRic)for the whole community and for species with different resource-use strategies.Specifically,based on data for four traits representing leaf economics spectrum(leaf carbon concentration,leaf nitrogen concentration,leaf phosphorus concentration,and specific leaf area),we divided 81 plant species appearing in the grassland community into three plant functional types representing resource-acquisitive,medium,and resource-conservative species.We then analyzed the changes in community-level productivity in response to the decline of SR and FRic at the community level and for different resource-use strategies.We found that community-level SR and FRic decreased with drying climate,which was largely driven by the decline of diversity for resource-acquisitive species.However,community-level productivity remained stable because resource-conservative species dominating this grassland were barely affected by climate change.Our study revealed distinctive responses of species with different resource-use strategies to climate change and provided a new approach based on species functional traits for predicting the magnitude and direction of climate change effects on ecosystem functions.

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