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癌症生物学与医学（英文版）
癌症生物学与医学（英文版）

郝希山

季刊

2095-3941

editor@cancerbiomed.org

022-23522919

300060

天津市河西区体院北环湖西路天津市肿瘤医院C座综合楼三楼

癌症生物学与医学（英文版）/Journal Cancer Biology & MedicineCSCDCSTPCD北大核心SCI
查看更多>>Cancer Biology & Medicine is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China. The scope covers the following topics:● Cancer epigenetics● Cancer stem cell● Improved in vivo and in vitro cancer models● Cancer prevention and epidemiology● Biomarkers for predicting drug response● Mechanism of drug sensitivity and resistance● New approaches for cancer detection and diagnosis● Oncology clinical trials● Targeted therapy● Multidisciplinary treatment for cancerAuthor benefits: ● Easy online submission via Editorial Manager● Efficient and professional peer-review by expert referees from around the world● Rapid pre-print online publication● No charge for publication and Open Access● International visibility - the journal is available free online
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    Hodgkin's lymphoma:2023 update on treatment

    Sicong ZhangXianming LiuLanfang LiLihua Qiu...
    269-273页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Neoantigen cancer vaccines:a new star on the horizon

    Xiaoling LiJian YouLiping HongWeijiang Liu...
    274-311页
    查看更多>>摘要：Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer cells.One of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal cells.Although neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint inhibitors.Progress made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of neoantigens.Consequently,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents recurrences.This review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

    Qian ZhangMingran YangPeng ZhangBowen Wu...
    312-330页
    查看更多>>摘要：Gastric cancer(GC),the fifth most common cancer globally,remains the leading cause of cancer deaths worldwide.Inflammation-induced tumorigenesis is the predominant process in GC development;therefore,systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks.Here,we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis,and characterize the multi-omics data and systems biology methods for investigating GC development.Of note,we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis,and we propose translational applications in early GC warning biomarkers and precise treatment strategies.This review offers integrative insights for GC research,with the goal of paving the way to novel paradigms for GC precision oncology and prevention.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

    Shuangcheng LiTianci WangXinghui XiaoXiaodong Zheng...
    331-346页
    查看更多>>摘要：Objective:The human cluster of differentiation(CD)300A,a type-Ⅰ transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs,was investigated as a potential immune checkpoint for human natural killer(NK)cells targeting hematologic malignancies(HMs).Methods:We implemented a stimulation system involving the CD300A ligand,phosphatidylserine(PS),exposed to the outer surface of malignant cells.Additionally,we utilized CD300A overexpression,a CD300A blocking system,and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings.Furthermore,we explored the association between CD300A and HM progression in patients.Results:Our findings indicated that PS hampers the function of NK cells.Increased CD300A expression inhibited HM lysis by NK cells.CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells.Blocking PS-CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells,thereby augmenting the ability to lyse HMs.Clinically,heightened CD300A expression correlated with shorter survival and an"exhausted"phenotype of intratumoral NK cells in patients with HMs or solid tumors.Conclusions:These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma:a multicenter cohort study in China

    Jian ChenZhe YangFengqiang GaoZhisheng Zhou...
    347-362页
    查看更多>>摘要：Objective:Sex-specific differences are observed in various liver diseases,but the influence of sex on the outcomes of hepatocellular carcinoma(HCC)after liver transplantation(LT)remains to be determined.This study is the first Chinese nationwide investigation of the role of sex in post-LT outcomes in patients with HCC.Methods:Data for recipients with HCC registered in the China Liver Transplant Registry between January 2015 and December 2020 were analyzed.The associations between donor,recipient,or donor-recipient transplant patterns by sex and the post-LT outcomes were studied with propensity score matching(PSM).The survival associated with different sex-based donor-recipient transplant patterns was further studied.Results:Among 3,769 patients enrolled in this study,the 1-,3-,and 5-year overall survival(OS)rates of patients with HCC after LT were 96.1%,86.4%,and 78.5%,respectively,in female recipients,and 95.8%,79.0%,and 70.7%,respectively,in male recipients after PSM(P = 0.009).However,the OS was comparable between recipients with female donors and male donors.Multivariate analysis indicated that male recipient sex was a risk factor for post-LT survival(HR = 1.381,P = 0.046).Among the donor-recipient transplant patterns,the male-male donor-recipient transplant pattern was associated with the poorest post-LT survival(P<0.05).Conclusions:Our findings highlighted that the post-LT outcomes of female recipients were significantly superior to those of male recipients,and the male-male donor-recipient transplant pattern was associated with the poorest post-LT survival.Livers from male donors may provide the most benefit to female recipients.Our results indicate that sex should be considered as a critical factor in organ allocation.
      原文链接:
    • NETL
    • NSTL
    • 万方数据