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期刊信息/Journal information
中华预防医学杂志
中华医学会杂志社
中华预防医学杂志

中华医学会杂志社

陈君石

月刊

0253-9624

cjpm@cma.org.cn

010-85158377

100710

北京市东城区东四西大街42号

中华预防医学杂志/Journal Chinese Journal of Preventive MedicineCSCD北大核心CSTPCD
查看更多>>1953年10月创刊,中华医学会主办。本刊是学界中历史最悠久的公认的核心期刊。刊登内容涵盖流行病学、环境卫生、营养与食品卫生、劳动卫生、儿童少年卫生学、卫生毒理、疾病检测与计划免疫、疾病预防与健康促进等所有预防医学与公共卫生类学科。多年来一直被美国医学索引(Medline)、化学文摘(CA)、生物学文摘(BA)等国内外20余种重要数据库收录。2006—2009年连续4年被评为“精品科技期刊(C类)”,在2007年被评为中国百种杰出学术期刊。
正式出版
收录年代

    数字化服务提高预防接种管理水平的思考与建议

    栾琳刘娜郑本锋张琢玉...
    159-165页
    查看更多>>摘要:随着信息技术发展和人民群众预防接种服务需求的提高,通过数字化提高预防接种服务质量已是必然趋势。本文从明确预防接种数字化服务概念入手,介绍当前国内外发展现况,分析先行地区现有模式的优势及存在的不足,借鉴总结并提出针对性解决建议,指出应建立数据互通共享的部门协调机制、制定数据标准及功能性规范、完善免疫规划信息系统功能、加强数据收集与分析利用、强化预约管理和科普教育,为后期全国各地预防接种数字化服务的建设提供专家指引。 With the development of information technology and the increasing demand for vaccination services among the people, it is a definite trend to enhance the quality of vaccination services through digitization. This article starts with a clear concept of digital services for vaccination, introduces the current development status in China and abroad, analyzes the advantages and disadvantages of existing models in leading regions, takes a glean from the summation, and proposes targeted solutions. This study suggests establishing a departmental coordination mechanism for data interconnection and sharing, formulating data standards and functional specifications, enhancing the functionalities of the immunization planning information system, strengthening data collection and analytical usage, and intensifying appointment management and science and health education to provide expert guidance for the construction of digital vaccination services across the country in the future.

    免疫规划数字化预防接种服务

    出生缺陷分子诊断的现状与思考

    祁明傅启华张晓青徐巍...
    166-170页
    查看更多>>摘要:出生缺陷是影响我国出生人口素质和威胁儿童健康的重大问题,遗传因素是导致出生缺陷的重要原因。对于由遗传因素所致的出生缺陷,分子诊断是其筛查、确诊与预防的关键手段。如何在临床开展大规模经济有效的分子诊断与筛查,是我国出生缺陷防治领域的重大挑战。本文将从我国出生缺陷疾病现状、分子诊断技术在出生缺陷防控中的应用及该技术在临床推广所面临的挑战等方面展开述评,以期为出生缺陷分子诊断的临床实践提供参考。 Birth defects are a major problem threatening the health of children in China. Genetic factors play a major role in birth defect etiology. Molecular diagnosis is the key means for screening, diagnosing, and preventing birth defects caused by genetic factors. How to carry out large-scale and cost-effective molecular diagnosis in clinical practice is a major challenge in the prevention and treatment of birth defects in China. This article reviews the current status of birth defects in China, the application of molecular diagnostic technology in birth defect prevention and control, and the challenges in promoting its use, to provide references for clinical practice in birth defect molecular diagnosis.

    分子诊断技术出生缺陷基因组学高通量测序述评

    脓毒症动物模型研究现状及思考

    叶青尚世强徐巍
    171-176页
    查看更多>>摘要:感染性疾病是导致儿童死亡的首要原因,脓毒症则是一种全球性导致儿童死亡的重要感染性危重疾病,病死率高,严重威胁儿童的健康。早期诊断已成为治疗严重脓毒症的关键。脓毒症动物模型的建立有助于更好地诊断脓毒症,从而采取干预措施,改善脓毒症患者的预后。本文就现有脓毒症动物模型的种类及优缺点等进行综述,并提出脓毒症动物模型的优化建议,为实验模型的选择和优化提供参考依据,以促进其“逆向转化”到临床的能力。 Infectious diseases are the leading cause of death in children. Sepsis is a critical infectious disease that causes death in children globally, with a high morbidity and mortality rate. It poses a serious threat to children′s health. Early diagnosis has become the key to treating severe sepsis. The establishment of animal models of sepsis can help people better diagnose sepsis and take interventions to improve the prognosis of sepsis patients. This study reviews the types, advantages and disadvantages of existing animal models of sepsis and proposes the optimization of these models to provide a reference basis for the selection and optimization of experimental models and the promotion of the "reverse transformation" of sepsis into clinical practice.

    脓毒症动物模型临床转化

    儿童癌症幸存者身体活动现状的研究进展

    徐凤娇张栗缪冰慧王蓓佳...
    177-182页
    查看更多>>摘要:大量儿童癌症幸存者面临着严重且持久的并发症或后遗症,对其健康造成了很大损害。充足的身体活动可以有效减轻这些并发症或后遗症的负面影响,但身体活动水平低下在儿童癌症幸存者群体中普遍存在。由于当前国际上缺乏针对儿童癌症幸存者身体活动的指南,如何正确指导儿童癌症幸存者参与身体活动存在诸多困难,因此有必要对儿童癌症幸存者身体活动的相关研究进行归纳总结。本文就身体活动的概念及测量、推荐量及国内外儿童癌症幸存者的身体活动参与情况进行综述,以期为促进我国儿童癌症幸存者身体活动水平提供参考。 Many childhood cancer survivors are suffering serious and long-lasting complications or sequelae, taking a significant toll on their health. Adequate physical activity can be effective in mitigating the negative effects of these complications or sequelae. However, low levels of physical activity are prevalent among childhood cancer survivors. Due to the lack of guidelines on physical activity for childhood cancer survivors, there are many difficulties in correctly guiding childhood cancer survivors to participate in physical activity. Therefore, it is necessary to summarize the relevant studies on the physical activity of childhood cancer survivors. This article provides a review of the concept and measurement of physical activity, recommended amount, and the participation of childhood cancer survivors both domestically and internationally, in order to provide a reference for promoting the physical activity level of Chinese childhood cancer survivors.

    儿童癌症幸存者身体活动综述

    McCune-Albright 综合征的致病机制及诊治研究进展

    母丹刘洪倩徐巍
    183-190页
    查看更多>>摘要:McCune-Albright综合征是一种由于合子后GNAS基因突变导致的罕见嵌合体性疾病,属于鸟核苷酸结合蛋白病,影响范围广泛,以骨纤维发育不良、咖啡牛奶斑及性早熟为特征,并伴有其他可变的临床表现。目前针对McCune-Albright综合征,分子诊断存在困难,临床上缺乏有效的治疗方法来阻止或逆转病程及转归。本文分析归纳了McCune-Albright综合征的临床表现、诊断、致病分子机制、治疗现状以及相关的生育指导,以期为McCune-Albright综合征的进一步研究和治疗提供借鉴。 McCune-Albright syndrome is a rare chimeric disorder due to mutations in the postzygotic GNAS gene. It belongs to the group of guanine nucleotide-binding protein diseases, affecting a wide range of individuals. It is characterized by fibrous dysplasia, café-au-lait skin macules, and precocious puberty with other variable clinical manifestations. At present, there are difficulties in the molecular diagnosis of McCune-Albright syndrome, and there is a lack of effective clinical treatments to halt or reverse the course and regression of the disease. This article summarizes the clinical manifestations, diagnosis, pathogenic molecular mechanisms, treatment and relevant fertility guidelines of McCune-Albright syndrome, with a view to further research and therapy of McCune-Albright syndrome.

    McCune-Albright综合征诊断治疗分子机制

    孕产期相关因素对儿童屈光不正影响的研究进展

    朱冬青陶舒曼陶芳标徐巍...
    191-195页
    查看更多>>摘要:屈光不正是儿童眼科常见疾病,是指眼睛的轴向长度与屈光力不匹配而造成视觉模糊,通常是由遗传和环境因素交互作用导致的。孕产期相关因素对儿童屈光不正的影响逐渐受到关注,本文对孕产期不同阶段进行分类,重点从孕期生活方式、妊娠期并发症及合并症、不良妊娠结局和其他因素4个方面对儿童屈光不正影响进行综述,旨在为儿童屈光不正防控提供围生期保健线索,实现防控关口前移,减轻因儿童屈光不正带来的公共卫生负担。 Refractive error is a common ophthalmic disease in children. It refers to the mismatch between the axial length and the refractive power that results in visual blur, which is usually driven by the interaction of genetic and environmental factors. The impacts of pregnancy and puerperium-related factors on refractive error in children have gradually gained attention. According to the different stages of pregnancy, this review summarizes the impacts of four aspects on refractive error in children, including lifestyle during pregnancy, complications and comorbidities during pregnancy, adverse pregnancy outcomes and other factors, which aims to provide perinatal healthcare clues for the prevention and control of refractive error in children, achieve prevention beforehand and reduce the public health burden of refractive error in children.

    屈光不正儿童孕期环境因素

    儿童变应性鼻炎影响因素研究进展

    韩学丽刘晓玲徐巍
    196-201页
    查看更多>>摘要:变应性鼻炎(AR)发病率逐年增高,儿童尤为明显。AR不仅影响患儿的生长发育、生活和学习,同时还会造成巨大的经济和社会负担,本文从儿童AR受基因多态性、表观遗传学、炎症反应机制、微生态影响机制等个人方面内因对疾病的影响;以及变应性因素、环境空气污染物因素、感染和免疫因素、气候及气候变化等外因对疾病的影响进行综述,旨在提高对儿童AR的认识,以期为其预防及治疗提供依据。 The incidence of allergic rhinitis (AR) is increasing year by year, especially in children. AR not only affects the growth, development, life and learning of children but also causes huge economic and social burdens. This study explores the impact of individual factors such as genetic polymorphisms, epigenetics, inflammatory response mechanisms, and microecological influence mechanisms on children′s AR. It also reviews the impact of external factors such as allergenic factors, ambient air pollutants, infection and immunity factors, and climate and climate change on the disease, with the aim of improving understanding of AR in children and providing a basis for its prevention and treatment.

    变应性鼻炎儿童影响因素

    河南省0~14岁青少年人群乙型肝炎病毒感染血清流行病学分析及儿童乙型肝炎疫苗免疫规划效果初步评估

    郭永豪陈艳萍豆巧华刘倩...
    202-207页
    查看更多>>摘要:目的 分析河南省0~14岁青少年人群乙型肝炎(乙肝)病毒感染血清流行病学特征及对儿童乙肝疫苗免疫规划效果进行初步评估。 方法 于2021年9月至2022年3月,以河南省18个省辖市的村/社区为研究现场,采用多阶段随机整群抽样的方法,抽取25个村或者社区的4 883名0~14岁青少年人群为研究对象。通过调查问卷收集人口学资料,并对0~4岁对象采集3 ml血样,5~14岁对象采集5 ml血样,检测HBsAg、HBcAb和HBsAb。通过河南省免疫信息系统收集乙肝疫苗接种数据,通过中国传染病报告系统收集河南省的乙肝病例,并分析儿童乙肝疫苗免疫规划效果。 结果 4 883名研究对象年龄为(7.32±2.81)岁,HBsAg和HBcAb的阳性率分别为0.1%(7/4 883)和1.0%(50/4 883),按照人口标化后的率分别为0.3%和1.7%。2002年河南省0~14岁青少年人群HBsAg阳性率为3.39%,与2002年相比,2022年河南省0~14岁青少年人群减少了约70万HBV慢性感染者。2002年出生的新生儿完成全部3针次疫苗接种率为6.26%,2003年乙肝疫苗接种率迅速上升,2013年首次达到90%,2014年后河南省乙肝接种率持续保持在95%以上。临床报告病例中1~4岁儿童病例的占比由2006年的0.43%(1 108/256 566)下降至2021年的0.01%(78/80 655);5~19岁青少年病例的占比由2006年18.21%(46 710/256 566)下降到2021年的1.1%(827/80 655)。 结论 2002—2022年河南省0~14岁青少年人群的HBsAg阳性率明显下降;儿童乙肝疫苗免疫规划的实施效果较好。 Objective To analyze the seroepidemiological characteristics of hepatitis B virus (HBV) infection among adolescents aged 0-14 years in Henan Province and to evaluate the effectiveness of the childhood hepatitis B vaccine (HepB) immunization program. Methods From September 2021 to March 2022, a total of 4 883 adolescents aged 0-14 years were selected from 25 villages or communities of 18 provincial-level cities in Henan Province by using the multi-stage random cluster sampling method. Demographic data were collected through questionnaires. The 3 ml of blood samples were collected from individuals aged 0-4 years and 5 ml of blood samples were collected from individuals aged 5-14 years to test HBsAg, HBcAb and HBsAb. Data on vaccination were collected through Henan Provincial Immunization Information System and hepatitis B cases in Henan Province were collected through China Infectious Disease Reporting System. The effectiveness of the childhood HepB immunization program was analyzed. Results The average age of 4 883 subjects was (7.32±2.81) years old. The positive rates of HBsAg and HBcAb were 0.1% (7/4 883) and 1.0% (50/4 883), and the population standardized rates were 0.3% and 1.7%. In 2002, the positive rate of HBsAg among adolescents aged 0-14 years in Henan Province was 3.39%. Compared with that in 2002, the number of chronic HBV infections among adolescents in Henan Province in 2022 decreased by about 0.7 million. In 2002, the vaccination rate of newborns who completed all three doses of vaccine was 6.26%. In 2003, the vaccination rate of the hepatitis B vaccine rose rapidly, reaching 90% in 2013 for the first time. After 2014, the vaccination rate in Henan Province continued to remain above 95%. The proportion of cases among children aged 1-4 years in clinical reports decreased from 0.43% (1 108/256 566) in 2006 to 0.01% (78/80 655) in 2021. The proportion of cases among adolescents aged 5-19 years decreased from 18.21% (46 710/256 566) in 2006 to 1.1% (827/80 655) in 2021. Conclusions From 2002 to 2022, the positive rate of HBsAg among adolescents aged 0-14 years has decreased significantly in Henan Province. The effectiveness of the HepB immunization program for children is good.

    肝炎,乙型疫苗接种

    中国长江中下游地区3省份学龄前儿童睡眠状况与偶测高血压的关联研究

    段小磊胡龙兵汪雅丽童娟...
    208-212页
    查看更多>>摘要:目的 了解中国长江中下游地区3个省份的学龄前儿童偶测高血压流行状况并分析睡眠状况与偶测高血压的关联。 方法 2017年10—11月采用立意抽样方法于湖北、安徽、江苏3省份抽取11个城市109所幼儿园的24 842名学龄前儿童作为对象。采用自制问卷收集对象基本情况,采用《儿童睡眠习惯问卷》收集对象睡眠状况资料,对对象进行体格检查,现场测量身高、体重和血压。比较不同特征学龄前儿童偶测高血压检出率的差异,采用多因素logistic回归模型分析睡眠状况与偶测高血压检出率的关联情况。 结果 24 842名儿童的年龄为(4.4±1.0)岁,其中男童12 729名(51.2%),偶测高血压检出率为31.8%(7 907例)。不同性别、年龄组、家庭居住地、家庭经济状况、父母亲文化程度学龄前儿童偶测高血压检出率差异均具有统计学意义(均P<0.05)。睡眠不足10 h儿童偶测高血压检出率高于睡眠充足者,差异具有统计学意义(P<0.05)。多因素logistic回归分析结果显示:调整性别、年龄、家庭居住地、家庭经济状况、父母文化程度、父母吸烟史和体质等因素后,与对应参考组相比,睡眠时间不足10 h、睡觉时开灯和睡眠质量差的OR(95%CI)分别为1.09(1.03~1.15)、1.17(1.07~1.28)和1.04(0.91~1.18)。 结论 长江中下游3省份学龄前儿童偶测高血压检出率高,睡眠不足和睡觉时开灯与学龄前儿童偶测高血压存在正向关联。 Objective To understand the prevalence of occasional hypertension in preschool children in three provinces in the middle and lower reaches of the Yangtze River in China, and analyze the relationship between their sleep status and occasional hypertension. Methods From October to November 2017, a total of 24 842 preschool children from 109 kindergartens in 11 cities in Hubei, Anhui and Jiangsu provinces were selected by intentional sampling method. A self-made questionnaire was used to collect basic information about the subjects, and the sleep status data was collected by the Children′s Sleep Habits Questionnaire. Physical examinations were performed on the subjects, and height, weight and blood pressure were measured on-site. The difference in occasional hypertension detection rate among preschool children with different characteristics was compared, and the correlation between sleep status and occasional hypertension detection rate was analyzed by the multivariate logistic regression model. Results The age of the subjects was (4.4±1.0) years, including 12 729 boys (51.2%). The prevalence of occasional hypertension was 31.8% (7 907/24 842). The prevalence of occasional hypertension among preschool children in three provinces of the middle and lower reaches of the Yangtze River was 31.8%. There were statistically significant differences in the detection rate of occasional hypertension among preschool children of different genders, age groups, family residence, family economic status and parents′ education level (all P values<0.05). The detection rate of occasional hypertension in children with less than 10 hours of sleep was higher than those with sufficient sleep, and the difference was statistically significant (P<0.05). The results of multivariate logistic regression analysis showed that after adjusting for factors such as gender, age, family residence, family economic status, parental education level, parental smoking history, and physical constitution, the ORs (95%CI) for less than 10 hours of sleep, turning on the lights while sleeping, and poor sleep quality were 1.09 (1.03-1.15), 1.17 (1.07-1.28) and 1.04 (0.91-1.18), respectively, compared with the corresponding reference group. Conclusion The detection rate of occasional hypertension is high in preschool children in the middle and lower reaches of the Yangtze River and there is a positive correlation between insufficient sleep and turning on the light when sleeping and occasional hypertension in preschool children.

    儿童睡眠高血压横断面研究

    2020—2023年湖北省某儿童医院呼吸道合胞病毒的临床流行病学特征分析

    李洋李颖杜慧林亚欣...
    213-218页
    查看更多>>摘要:目的 探讨2020—2023年湖北地区儿童呼吸道合胞病毒的临床流行病学特征。 方法 本研究为单中心、横断面研究,对2020年7月1日至2023年6月30日在华中科技大学附属武汉儿童医院因呼吸道感染住院且进行了直接免疫荧光法检测提示呼吸道合胞病毒(RSV)阳性患儿的临床资料共3 271例进行分析。采用非参数秩和检验及χ2进行比较分析。 结果 共纳入因呼吸道感染住院患儿25 583例,其中RSV阳性的3 271例(12.8%)。2020—2021年、2021—2022年、2022—2023年RSV的检出率分别为16.3%(874/5 351)、14.7%(1 462/9 921)、9.1%(935/10 311),呈逐年下降趋势(χ2=222.054,P<0.05)。2020—2023年春季和秋季出现了RSV非典型季节流行。1岁以下婴儿的RSV检出率最高,2020—2021、2021—2022及2022—2023年度RSV阳性患儿的中位年龄分别为12月龄、12月龄、24月龄,患儿中位年龄有增大(H=140.575,P<0.05)。RSV呼吸道感染后均以肺炎为主要临床表现。 结论 2020—2023年湖北地区儿童RSV的流行病学特征有所变化,RSV的检出率呈逐年下降趋势;除冬季外,春季和秋季也可见RSV的流行,RSV感染患儿的中位年龄增大,肺炎是RSV感染后的主要临床表现。 Objective To explore the clinical epidemiological characteristics of respiratory syncytial virus in children in Hubei Province from 2020 to 2023. Method A single-center and cross-sectional study was used to analyze the clinical data of 3 271 children with respiratory syncytial virus infection in Wuhan Children′s Hospital affiliated to Huazhong University of Science and Technology from July 1, 2020 to June 30, 2023. Nonparametric rank sum test andχ2 test were used for comparative analysis. Results From July 1, 2020 to June 30, 2023, a total of 25 583 children were included in the analysis, of which 3 271(12.8%) children infected RSV. The detection rate was 16.3% in 2020-2021, 14.7% in 2021-2022 and 9.1% in 2022-2023. The detection rate decreased year by year (χ2=222.054, P<0.05). From 2020 to 2023, there was an anti-seasonal epidemic of RSV in spring and autumn. The detection rate of RSV in infants under 1 year old was the highest, but the median ages of RSV positive children increased (H=140.575, P<0.05). Pneumonia was the main clinical manifestation of RSV respiratory tract infection. Conclusion The epidemiological characteristics of RSV in children in Hubei Province were different from those before. From 2020 to 2023, the detection rate of RSV decreased year by year. Besides winter, the prevalence of RSV could also be seen in spring and autumn. The median age of children infected with RSV increased after the epidemic. Pneumonia was the main clinical manifestation after RSV infection.

    呼吸道合胞病毒临床流行病学呼吸道感染儿童