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结合医学学报(英文版)
结合医学学报(英文版)

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报(英文版)/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊,是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》(Index Medicus/MEDLINE/PubMed)收录期刊。 《中西医结合学报》是开放获取期刊,已被列入《开放获取期刊指南》(Directory of Open Access Journals, DOAJ),所有被录用的稿件均经过同行评议,同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊,设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版,全球发行;网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录,并且可以在PubMed即时链接本刊网站,免费阅读所检索的论文全文。 中西医结合学报杂志社(JCIM Press)是出版者国际链接联合会(Publisher International Linking Association, PILA)和CrossRef的机构会员,与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号,并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度,最便捷的方式,最大范围地向世界展示您的研究成果。 我们的办刊方针:坚持学术期刊的导向作用,履行学术期刊的社会责任,倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念:只争朝夕,只求卓越;尽我所能,做到更好。 我们的办刊目的:向世界展示中国中西医结合研究的成果,向中国读者介绍世界结合医学的进展,为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向:编辑出版国际一流医学期刊,打造国际化精品期刊、品牌期刊。
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    Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

    Yong-guang FangShi-lin HuangNan-nan Chen
    614-620页
    查看更多>>摘要:Introduction:There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant APL.Case presentation:Two patients in the first relapse and one in the second relapse failed to achieve hema-tologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission therapy.These eight patients received RIF in three doses per day totaling 130 mg/kg(≤ 30 pills)as induction therapy and achieved HCR at a median time of 46.5 days.They received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by RIF.During this period,the patients did not experience renal dysfunction or QT interval pro-longation.At the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and died.The 5-year overall survival and event-free survival rates were 75.0%(95%confi-dence interval[CI]:31.5-93.1)and 37.5%(95%CI:5.6-71.7),respectively.Conclusion:RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.