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中国实用医刊
中国实用医刊

秦省

半月刊

1674-4756

zgsyyk@163.com

0371-65920096

450003

河南省郑州市经三路七号

中国实用医刊/Journal Chinese Journal of Practical Medicine
查看更多>>1974年1月创刊，中华人民共和国卫生部主管，中华医学会主办。本刊原名《中原医刊》，中国期刊全文数据库全文收录期刊、中国学术期刊综合评价数据库统计刊源期刊、中国核心期刊（遴选）数据库收录期刊、万方数据-数字化期刊群收录期刊。重点报道内、外、妇、儿等学科进展，以及新理论、新成果等。设有论著、临床实践、经验交流、临床研究、药物与临床、综述、误诊分析等栏目。
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    表皮生长因子受体酪氨酸酶抑制剂治疗晚期非小细胞肺癌的疗效及安全性

    李运马佩宋佳音马文娟...
    78-81页
    查看更多>>摘要：目的 分析表皮生长因子受体酪氨酸酶抑制剂(EGFR-TKI)治疗晚期非小细胞肺癌的临床疗效及安全性。 方法 随机对照研究。抽取2022年1月至2023年1月郑州大学第一附属医院收治的98例晚期非小细胞肺癌患者作为研究对象，按随机数字表法分为对照组和观察组，每组49例。对照组予以化疗，观察组予以化疗联合EGFR-TKI治疗。比较两组临床疗效、肿瘤标志物水平[细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)及鳞状细胞癌抗原(SCC)]与不良反应发生情况。 结果 治疗后，观察组患者的客观缓解率(69.39%，34/49)高于对照组(48.98%，24/49)，P<0.05。治疗后，两组CYFRA21-1、CEA、NSE及SCC水平均低于同组治疗前，且观察组各项指标低于对照组(P<0.05)；两组不良反应发生情况比较差异未见统计学意义(P>0.05)。 结论 晚期非小细胞肺癌临床治疗中应用EGFR-TKI有助于提高患者的临床疗效，下调肿瘤标志物表达，且安全性高。 Objective To analyze the clinical efficacy and safety of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in the treatment of advanced non-small cell lung cancer. Methods This study was a randomized controlled trail. A total of 98 patients with advanced non-small cell lung cancer admitted to the First Affiliated Hospital of Zhengzhou University from January 2022 to January 2023 were selected as the study subjects, and they were divided into control group and observation group by random number table method, with 49 cases in each group. The control group was treated by chemotherapy, while the observation group was treated with EGFR-TKI. The clinical efficacy, levels of tumor markers, including cytokeratin fragment (CYFRA21-1), carcinoembryonic antigen (CEA), neuronspecific enolase (NSE) and squamous cell carcinoma antigen (SCC), and incidence of adverse reactions of the two groups were compared. Results After treatment, the objective response rate of the observation group (69.39%, 34/49) was higher than that of the control group (48.98%, 24/49), P<0.05. After treatment, the levels of CYFRA21-1, CEA, NSE and SCC in both groups were lower than those before treatment, and the above indicators in the observation group were lower than those in the control group (P<0.05). There was no significance in the incidence of adverse reactions between the two groups (P>0.05). Conclusions The application of EGFR-TKI in the clinical treatment of advanced non-small cell lung cancer is conductive to improving the clinical efficacy and down-regulating the expression of tumor markers, with high safety.

    非小细胞肺癌表皮生长因子受体酪氨酸酶抑制剂临床疗效肿瘤标志物安全性

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    甘露特钠联合多奈哌齐治疗阿尔茨海默病的效果及对患者认知功能的影响

    张黎军王亚宇李东丽王凡...
    82-85页
    查看更多>>摘要：目的 分析甘露特钠联合多奈哌齐治疗阿尔茨海默病的效果及对患者认知功能的影响。 方法 随机对照研究。抽取2021年1月至2023年3月新乡医学院第一附属医院收治的阿尔茨海默病患者56例，按随机数字表法分为观察组和对照组，每组28例。对照组采用多奈哌齐治疗，观察组在对照组基础上给予甘露特钠治疗。比较两组治疗效果、认知功能评分[简易精神状态检查表(MMSE)、阿尔茨海默病评定量表-认知量表(ADAS-cog)]、精神行为症状评分[Cohen-Mansfield激越问卷(CMAI)、痴呆行为评定量表(BRSD)]、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]水平、肠道菌群代谢标志物[苯丙氨酸(Phe)、短链脂肪酸(SCFA)]、脑脊液生物标志物[β-内啡肽(β-EP)、亮氨酸-脑啡肽(LEK)]。 结果 观察组治疗总有效率(96.43%，27/28)与对照组(82.14%，23/28)比较差异未见统计学意义(P>0.05)。治疗后，观察组MMSE评分高于对照组，ADAS-cog评分低于对照组(P<0.05)。治疗后，观察组CMAI、BRSD评分低于对照组(P<0.05)。治疗后，观察组TNF-α、IL-6水平低于对照组，IL-10水平高于对照组(P<0.05)。治疗后，观察组Phe低于对照组，SCFA高于对照组(P<0.05)。治疗后，观察组β-EP水平高于对照组，LEK水平低于对照组(P<0.05)。 结论 甘露特钠治疗阿尔茨海默病患者，可调节脑脊液生物标志物和肠道菌群代谢标志物表达，减轻炎症反应，改善认知功能和精神行为症状，临床效果显著。 Objective To analyze the effects of sodium oligomannate combined with donepezil in the treatment of Alzheimer disease, and its influence on cognitive function. Methods This study was a randomized controlled trail. Fifty-six patients with Alzheimer disease treated in the First Affiliated Hospital of Xinxiang Medical University from January 2021 to March 2023 were selected, and they were divided into observation group and control group according to the random number table method, with 28 cases in each group. The control group was treated with donepezil, and the observation group was treated with sodium oligomannate based on the treatment of the control group. The efficacy, cognitive function scores evaluated by mini-mental state examination (MMSE) and Alzheimer disease assessment scale-cognitive (ADAS-cog), mental and behavioral symptoms scores assessed by the Cohen-Mansfield agitation inventory (CMAI) and behavior rating scale of dementia (BRSD), levels of inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10), intestinal flora metabolic markers, including phenylalanine (Phe) and short chain fatty acids (SCFA), and cerebrospinal fluid biomarkers, including β-endorphin (β-EP) and leucine enkephalin (LEK), were compared between the two groups. Results There was no significant difference in the total effective rate between the observation group (96.43%, 27/28) and the control group (82.14%, 23/28), P>0.05. After treatment, the MMSE score of the observation group was higher than that of the control group, and the ADAS-cog score was lower than that of the control group (P<0.05). After treatment, the scores of CMAI and BRSD of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of TNF-α and IL-6 in the observation group were lower than those in the control group, and the level of IL-10 was higher than that in the control group (P<0.05). After treatment, the observation group had lower Phe and higher SCFA, compared with the control group (P<0.05). After treatment, the observation group had higher level of β-EP and lower level of LEK, compared with the control group (P<0.05). Conclusions Sodium oligomannate in the treatment of Alzheimer disease can regulate the expression of cerebrospinal fluid biomarkers and intestinal flora metabolic markers, reduce inflammatory response, improve cognitive function and mental and behavioral symptoms, of which the clinical effect is significant.

    阿尔茨海默病甘露特钠认知功能脑脊液生物标志物

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    美罗培南注射剂联合乌司他丁治疗脓毒症休克的效果观察

    李娜赵青王志远李佳佳...
    86-89页
    查看更多>>摘要：目的 分析美罗培南注射剂联合乌司他丁治疗脓毒症休克的效果。 方法 随机对照研究。抽取2019年3月至2023年2月郑州人民医院收治的60例脓毒症休克患者为研究对象，基于简单随机化法分为联合组与对照组，每组30例。对照组采用美罗培南注射剂治疗，联合组采用美罗培南注射剂联合乌司他丁治疗。比较两组疗效、心肌功能[脑钠肽、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)]、肝功能[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)]、肾功能[血肌酐、尿素氮、中性粒细胞明胶酶相关脂质转运蛋白(NGAL)]、血清炎症因子[血清淀粉样蛋白A(SAA)、肝素结合蛋白(HBP)、C反应蛋白(CRP)]水平、多器官功能障碍综合征(MODS)发生率。 结果 联合组总有效率(96.67%，29/30)高于对照组(73.33%，22/30)，P<0.05。治疗后，联合组脑钠肽、CK-MB、cTnI水平低于对照组(P<0.05)。治疗后，联合组AST、ALT、TBiL水平低于对照组(P<0.05)。治疗后，联合组血肌酐、尿素氮、NGAL水平低于对照组(P<0.05)。治疗后，联合组SAA、HBP、CRP水平低于对照组(P<0.05)。联合组MODS发生率(6.67%，2/30)低于对照组(26.67%，8/30)，P<0.05。 结论 美罗培南注射剂联合乌司他丁治疗脓毒症休克可提高疗效，减轻心肌功能、肝肾功能损害，并能减轻炎症反应，降低MODS发生率。 Objective To analyze the effect of meropenem injection combined with ulinastatin in the treatment of septic shock. Methods This study was a randomized controlled trail. A total of 60 patients with septic shock treated in People’s Hospital of Zhengzhou from March 2019 to February 2023 were selected as research objects. And they were divided into combined group and control group according to simple randomization method, with 30 cases in each group. The control group was treated with meropenem injection, and the combined group was treated with meropenem injection combined with ulinastatin. The curative effect, myocardial function assessed by brain natriuretic peptide, creatine kinase isoenzymes (CK-MB) and cardiac troponin I (cTnI), liver function assessed by aspartate transaminase (AST), alanine aminotransferase (ALT) and total bilirubin (TBiL), renal function assessed by serum creatinine (Scr), blood urea nitrogen (BUN) and neutrophil gelatinase associated lipocalin (NGAL), levels of serum inflammatory factors, including serum amyloid A (SAA), heparin-binding protein (HBP) and C-reactive protein (CRP), and incidence of multiple organ dysfunction syndrome (MODS) were compared between the two groups. Results The total effective rate of the combined group (96.67%, 29/30) was higher than that of the control group (73.33%, 22/30), P<0.05. After treatment, the levels of BNP, CK-MB and cTnI in the combined group were lower than those in the control group (P<0.05). After treatment, levels of AST, ALT and TBiL in the combined group were lower than those in the control group (P<0.05). After treatment, levels of serum creatinine, blood urea nitrogen and NGAL in the combined group were lower than those in the control group (P<0.05). After treatment, the levels of SAA, HBP and CRP in the combined group were lower than those in the control group (P<0.05). The incidence of MODS in the combined group was 6.67% (2/30), lower than 26.67% (8/30) in the control group (P<0.05). Conclusions Meropenem injection combined with ulinastatin in the treatment of septic shock can improve the treatment efficacy, reduce impair on myocardial function, liver function and kidney function, reduce inflammatory response, and decrease the incidence of MODS.

    脓毒症休克美罗培南注射剂乌司他丁

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    奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的效果比较

    刘咪贺娜闫红林蒋宝玲...
    90-93页
    查看更多>>摘要：目的 比较奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的临床效果。 方法 随机对照研究。抽取2022年3月至2023年3月西安医学院第一附属医院收治的慢性胃炎患者92例，按随机数字表法分为对照组与观察组，每组46例。对照组采用奥美拉唑三联疗法，观察组采用雷贝拉唑三联疗法，两组均持续用药2周。比较两组临床疗效、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-2R(IL-2R)]、胃功能[胃泌素、胃动素、人表皮生长因子(EGF)、生长抑素]及不良反应。 结果 观察组临床总有效率(97.83%，45/46)高于对照组(82.61%，38/46)，P<0.05。治疗后，观察组TNF-α、IL-6、IL-2R水平低于对照组(P<0.05)。治疗后，观察组胃泌素、EGF水平低于对照组，胃动素、生长抑素水平高于对照组(P均<0.05)。观察组不良反应发生率(4.35%，2/46)与对照组(8.70%，4/46)比较差异未见统计学意义(P>0.05)。 结论 与奥美拉唑三联疗法相比，雷贝拉唑三联疗法对慢性胃炎的治疗效果更佳，利于减轻炎症反应，改善胃功能，且具有较好安全性。 Objective To compare the efficacy of omeprazole triple therapy and rabeprazole triple therapy in the treatment of chronic gastritis. Methods This study was a randomized controlled trail. A total of 92 patients with chronic gastritis admitted to the First Affiliated Hospital of Xi’an Medical University from March 2022 to March 2023 were selected. And they were divided into control group and observation group by random number table method, with 46 cases in each group. The control group received omeprazole triple therapy, while the observation group received rabeprazole triple therapy. Both groups were treated continuously for 2 weeks. The clinical efficacy, inflammatory factors, including tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) and interleukin-2R (IL-2R), gastric function assessed by gastrin, motilin, human epidermal growth factor (EGF) and somatostatin, and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group (97.83%, 45/46) was higher than that of the control group (82.61%, 38/46), P<0.05. After treatment, the levels of TNF-α, IL-6 and IL-2R in the observation group were lower than those in the control group (P<0.05). After treatment, the levels of gastrin and EGF in the observation group were lower than those in the control group, moreover, the levels of motilin and somatostatin in the observation group were higher than those in the control group (allP<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (4.35%, 2/46) and the control group (8.70%, 4/46),P>0.05. Conclusions Compared with omeprazole triple therapy, rabeprazole triple therapy has a better therapeutic effect in the treatment of chronic gastritis, which is conductive to reducing inflammatory response and improving gastric function, with good safety.

    胃炎奥美拉唑雷贝拉唑三联疗法临床疗效不良反应

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    克罗米酚联合二甲双胍治疗多囊卵巢综合征的效果及对患者性激素水平的影响

    翟一阳翟俊英钮红丽刘小敏...
    94-97页
    查看更多>>摘要：目的 分析克罗米酚联合二甲双胍治疗多囊卵巢综合征(PCOS)的效果及对患者性激素水平的影响。 方法 随机对照研究。抽取2020年6月至2022年6月南阳市第一人民医院收治的PCOS患者68例，按随机数字表法分为观察组与对照组，每组34例。对照组采用克罗米酚治疗，观察组在对照组基础上加用二甲双胍治疗。比较两组治疗效果、性激素水平[促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)]、促排卵效果、临床症状发生情况、胰岛素抵抗指数(HOMA-IR)及体质指数。 结果 观察组总有效率(97.06%，33/34)高于对照组(76.47%，26/34)，P<0.05。治疗后，观察组LH、FSH水平低于对照组，E2水平高于对照组(P<0.05)。观察组卵泡成熟时间短于对照组，子宫内膜厚度大于对照组(P<0.05)。治疗后，观察组痤疮、月经稀发、体毛增多发生率(5.88%，2/34；8.82%，3/34；.82%，3/34)均低于对照组(23.53%，8/34；29.41%，10/34；32.35%，11/34)，P<0.05。治疗后，观察组HOMA-IR水平低于对照组(P<0.05)。治疗后，观察组体质指数低于对照组(P<0.05)。 结论 克罗米酚联合二甲双胍治疗PCOS效果显著，可改善性激素水平、胰岛素抵抗情况和肥胖情况，显著提高促排卵效果。 Objective To analyze the curative effect of clomiphene combined with metformin on polycystic ovary syndrome, and its influence on sex hormones levels. Methods This study was a randomized contr olled trail. A total of 68 patients with polycystic ovary syndrome treated in Nanyang First People’s Hospital from June 2020 to June 2022 were selected, and they were divided into observation group and control group according to random number table method, with 34 cases in each group. The control group was given clomiphene, and the observation group was given metformin based on the treatment of the control group. The efficacy, levels of sex hormones, including luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E2), ovulation effect, clinical symptom occurrence, homeostatic model assessment for insulin resistance (HOMA-IR) and body mass index of the two groups were compared. Results The total effective rate of the observation group (97.06%, 33/34) was higher than that of the control group (76.47%, 26/34), P<0.05. After treatment, levels of LH and FSH in the observation group were lower than those in the control group, while level of E2 in the observation group was higher than that in the control group (P<0.05). The follicle maturation time of the observation group was shorter, and the endometrial thickness was thicker, compared with the control group (P<0.05). After treatment, the incidence of acne, oligomenorrhea and increased body hair in the observation group (5.88%, 2/34 8.82%, 3/34 8.82%, 3/34) were lower than those in the control group (23.53%, 8/34 29.41%, 10/34 32.35%, 11/34),P<0.05. After treatment, HOMA-IR level in the observation group was lower than that in the control group (P<0.05). After treatment, the body mass index of the observation group was lower than that of the control group (P<0.05). Conclusions Clomiphene combined with metformin in the treatment of polycystic ovary syndrome is effective, which can improve the sex hormones levels, insulin resistance and obesity. Moreover, it can significantly improve the effect of ovulation promotion.

    多囊卵巢综合征克罗米酚二甲双胍

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    唑来膦酸联合依降钙素在骨质疏松性骨折术后患者中的应用效果

    吕勤霞陈晨程艳红常青...
    98-101页
    查看更多>>摘要：目的 探讨唑来膦酸联合依降钙素在骨质疏松性骨折术后患者中的应用效果。 方法 随机对照研究。抽取2017年1月至2021年12月河南省中医院收治的骨质疏松性骨折术后患者74例，按照随机数字表法分为对照组和观察组，每组37例。对照组采用唑来膦酸治疗，观察组在对照组基础上采用依降钙素治疗。比较两组治疗效果，比较两组治疗前后骨密度、骨折愈合指标[碱性磷酸酶(ALP)、骨钙素(BGP)、胰岛素样生长因子(IGF)]、视觉模拟评分法(VAS)评分、Oswestry功能障碍指数(ODI)，比较两组不良反应发生率。 结果 观察组总有效率(97.30%，36/37)高于对照组(78.38%，29/37)，P<0.05。治疗后，观察组腰椎、股骨颈骨密度高于对照组(P<0.05)；治疗后，观察组ALP、BGP、IGF水平高于对照组(P<0.05)；治疗后，观察组VAS评分、ODI低于对照组(P<0.05)。观察组不良反应发生率(10.81%，4/37)与对照组(5.41%了，2/37)比较差异未见统计学意义(P>0.05)。 结论 唑来膦酸联合依降钙素应用于骨质疏松性骨折术后患者的效果显著，能改善腰椎和股骨颈骨密度，促进骨折愈合，缓解疼痛症状，改善患者功能障碍，且无明显不良反应。 Objective To investigate the application effect of zoledronic acid combined with elcatonin after surgery for osteoporotic fractures. Methods The randomized controlled study was conducted on 74 patients who had experienced surgery for osteoporosis fractures in Henan Traditional Chinese Medicine Hospital from January 2017 to December 2021. They were divided into control group and observation group by random number table method, with 37 cases in each group. The control group was treated with zoledronic acid, while the observation group was treated with elcatonin based on the treatment of the control group. The efficacy of the two groups were compared. The bone density, fracture healing indicators, including alkaline phosphatase (ALP), osteocalcin (BGP), insulin like growth factor (IGF), visual analogue scale (VAS) scores, and Oswestry dysfunction index (ODI) were compared between the two groups before and after treatment. And the incidence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group (97.30%, 36/37) was higher than that in the control group (78.38%, 29/37), P<0.05. After treatment, the bone density of the lumbar spine and femoral neck in the observation group were higher than those in the control group (P<0.05). After treatment, the levels of ALP, BGP and IGF in the observation group were higher than those in the control group (P<0.05). After treatment, the VAS score and ODI in the observation group were lower than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group (10.81%, 4/37) and the control group (5.41%, 2/37),P>0.05. Conclusions The combination of zoledronic acid with elcatonin has a significant effect on patients after surgery for osteoporosis fractures. It can improve the bone density of the lumbar spine and femoral neck, promote fracture healing, alleviate pain symptoms, and improve function disorder, without significant adverse reactions.

    骨质疏松骨折唑来膦酸依降钙素骨密度

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    不同浓度A型肉毒毒素治疗面肌痉挛的效果比较

    王少华张萌牛德旺马文娟...
    102-105页
    查看更多>>摘要：目的 比较不同浓度A型肉毒毒素治疗面肌痉挛的临床效果。 方法 随机对照研究。抽取2018年9月至2022年5月濮阳市安阳地区医院收治的面肌痉挛患者82例，按照随机数字表法分为高浓度组与低浓度组，每组41例。高浓度组注射50 U/mL的A型肉毒毒素；低浓度组注射25 U/mL的A型肉毒毒素。比较两组临床有效率、治疗后各个时间点的Cohen下降值、药物起效时间、药物持续时间和不良反应发生情况。 结果 高浓度组总有效率(95.12%，39/41)高于低浓度组(80.49%，33/41)，P<0.05。治疗后第1周至3个月内，两组Cohen下降值比较差异未见统计学意义(P>0.05)；治疗后第4、5个月，低浓度组Cohen下降值均小于高浓度组(P均<0.05)；治疗后第6～12个月，两组Cohen下降值趋于一致(P>0.05)。高浓度组药物起效时间短于低浓度组，持续时间长于低浓度组(P<0.05)。低浓度组不良反应发生率(4.88%，2/41)低于高浓度组(17.07%，8/41)，且低浓度组不良反应持续时间短于高浓度组(P<0.05)。 结论 不同浓度A型肉毒毒素治疗面肌痉挛各有优缺点，50 U/mL高浓度A型肉毒毒素虽能提高治疗效果，但不良反应的发生风险较高；25 U/mL低浓度A型肉毒毒素的效果虽不及高浓度，但安全性较高。 Objective To compare the clinical efficacy of different concentrations of botulinum toxin type A in the treatment of facial spasm. Methods This study was a randomized controlled trail. A total of 82 patients with facial spasm admitted to Anyang District Hospital in Puyang from September 2018 to May 2022 were selected, and they were divided into high concentration group and low concentration group by random number table method, with 41 cases in each group. The high concentration group was injected with botulinum toxin type A of 50 U/mL, the low concentration group was injected with botulinum toxin type A of 25 U/mL. The clinical effective rate, Cohen decrease at various time points after treatment, drug onset time, drug duration, and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the high concentration group (95.12%, 39/41) was higher than that of the low concentration group (80.49%, 33/41), P<0.05. Within the first week to three months after treatment, there was no significant difference in the decrease in Cohen values between the two groups (P>0.05). The decrease in Cohen values in the low concentration group was lower than that in the high concentration group at the fourth and fifth months after treatment (allP<0.05). The decrease in Cohen values in the two groups tended to be consistent from 6 to 12 months after treatment (P>0.05). The onset time of drugs in the high concentration group was shorter than that in the low concentration group, and the drug duration was longer than that in the low concentration group (P<0.05). The incidence of adverse reactions in the low concentration group (4.88%, 2/41) was significantly lower than that in the high concentration group (17.07%, 8/41), while the duration of adverse reactions in the low concentration group was shorter than that in the high concentration group (P<0.05). Conclusions Different concentrations of botulinum toxin A have their own advantages and disadvantages in the treatment of facial spasm. Choosing a high concentration of botulinum toxin A of 50 U/mL can improve the treatment effect, but the risk of adverse reactions is higher. Although the effect of low concentration of botulinum toxin type A (25 U/mL) is not as good as the high concentration, its safety is relatively high.

    A型肉毒毒素面肌痉挛浓度不良反应

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    激痛点刺络放血疗法治疗中风后抑郁的效果观察

    付丽娟钟芳芳孔维宽傅利霞...
    106-108页
    查看更多>>摘要：目的 探讨激痛点刺络放血疗法治疗中风后抑郁的临床效果。 方法 随机对照研究。抽取2022年1月至2022年12月聊城市第二人民医院收治的中风后抑郁患者70例，按照随机数字表法分为对照组与观察组，每组35例。对照组予以常规针刺疗法，观察组在对照组基础上联合激痛点刺络放血疗法。比较两组治疗效果，治疗前后中医症候积分、抑郁评分。 结果 观察组治疗总有效率(94.29%，33/35)高于对照组(77.14%，27/35)，P<0.05。治疗前，两组中医症候积比较差异未见统计学意义(P>0.05)，治疗后，观察组精神抑郁、善太息、胁肋胀痛、脾胃失调及脘闷嗳气评分低于对照组(P<0.05)；治疗前，两组抑郁评分比较差异未见统计学意义(P>0.05)，治疗后，观察组抑郁评分低于对照组(P<0.05)。 结论 激痛点刺络放血疗法用于中风后抑郁的治疗中能进一步改善患者中医症候积分，减轻抑郁症状，整体干预效果较好。 Objective To investigate the clinical effect of acupuncture and bloodletting at trigger points in the treatment of post-stroke depression. Methods This study was a randomized controlled study. A total of 70 patients with post-stroke depression admitted to the Second People’s Hospital of Liaocheng from January 2022 to December 2022 were selected. They were divided into control group and observation group by random number table method, with 35 cases in each group. The control group received routine acupuncture therapy, while the observation group received acupuncture and bloodletting at trigger points based on the treatment of the control group. The therapeutic effects of the two groups were compared. The traditional Chinese medicine symptom scores and depression scores of the two groups were compared before and after treatment. Results The total effective rate in the observation group (94.29%, 33/35) was higher than that in the control group (77.14%, 27/35), P<0.05. Before treatment, there was no statistically significant difference in the traditional Chinese medicine symptoms scores between the two groups (P>0.05). After treatment, the observation group had lower scores of depression, good breath, rib distension and pain, spleen-stomach imbalance, and belching in the epigastric cavity compared with the control group (P<0.05). Before treatment, there was no statistically significant difference in depression scores between the two groups (P>0.05). After treatment, the depression scores in the observation group were lower than those in the control group (P<0.05). Conclusions Acupuncture and bloodletting at trigger points in the treatment of post-stroke depression can further improve the traditional Chinese medicine syndrome score, and alleviate depressive symptoms, which has a good overall intervention effect.

    中风抑郁激痛点刺络放血针刺

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    复方丹参滴丸在急性心肌梗死经皮冠状动脉介入术后辅助治疗中的应用价值

    田亚宾李庆玉张甲臣常青...
    109-112页
    查看更多>>摘要：目的 分析复方丹参滴丸在急性心肌梗死经皮冠状动脉介入术(PCI)后辅助治疗中的应用价值。 方法 随机对照研究。抽取2021年2月至2023年2月安阳市中医院收治的150例行PCI治疗的急性心肌梗死患者，按随机数字表法分为中医组与西医组，每组75例。西医组术后给予常规治疗，中医组在西医组基础上给予复方丹参滴丸。比较两组临床效果、心功能[心脏指数(CI)、心脏每搏量(SV)、左室射血分数(LVEF)]、心肌损伤标志物[心肌肌钙蛋白T(cTnT)、心肌钙调蛋白依赖性蛋白激酶Ⅱ(CaMKⅡ)]水平、血液流变学指标[红细胞沉降率(ESR)、纤维蛋白原(FIB)、血浆黏度(PV)]及不良心血管事件发生率。 结果 中医组总有效率(97.33%，73/75)高于西医组(85.33%，64/75)，P<0.05。治疗后，中医组CI、SV、LVEF水平高于西医组(P<0.05)，cTnT、CaMKⅡ水平低于西医组(P<0.05)。治疗后，中医组ESR、FIB、PV低于西医组(P<0.05)。中医组不良心血管事件发生率(4.00%，3/75)低于西医组(14.67%，11/75)，P<0.05。 结论 复方丹参滴丸应用于急性心肌梗死患者PCI术后，可减轻患者的心肌损伤，改善血液流变学指标，提高心功能，并可降低不良心血管事件发生率。 Objective To analyze the application value of compound Danshen dropping pills in the adjuvant treatment of acute myocardial infarction after percutaneous coronary intervention (PCI). Methods This was a randomized controlled study. A total of 150 patients with acute myocardial infarction treated by PCI in Anyang Traditional Chinese Medicine Hospital from February 2021 to February 2023 were selected, and they were divided into traditional Chinese medicine group and western medicine group by random number table method, with 75 cases in each group. The western medicine group was treated by routine treatment after operation, and the traditional Chinese medicine group was treated with compound Danshen dropping pills based on the treatment of the western medicine group. The clinical effects, cardiac function assessed by cardiac index (CI), cardiac stroke volume (SV) and left ventricular ejection fraction (LVEF), levels of myocardial injury markers, including cardiac troponin T (cTnT) and cardiac calmodulin dependent protein kinase Ⅱ (CaMK Ⅱ), hemorheologic indexes, including erythrocyte sedimentation rate (ESR), fibrinogen (FIB) and plasma viscosity (PV), and incidence of adverse cardiovascular events were compared between the two groups. Results The total effective rate of the traditional Chinese medicine group was 97.33% (73/75), which was higher than the 85.33% (64/75) of the western medicine group (P<0.05). After treatment, the traditional Chinese medicine group had higher CI, SV and LVEF, and it had lower levels of cTnT and CaMKⅡ, compared with the western medicine group (P<0.05). After treatment, ESR, FIB and PV in the traditional Chinese medicine group were lower than those in the western medicine group (P<0.05). The incidence of adverse cardiovascular events in the traditional Chinese medicine group (4.00%, 3/75) was lower than that in the western medicine group (14.67%, 11/75),P<0.05. Conclusions Compound Danshen dropping pills used in patients with acute myocardial infarction after PCI can reduce myocardial injury, improve hemorheology and cardiac function, and reduce the incidence of adverse cardiovascular events.

    心肌梗死经皮冠状动脉介入术复方丹参滴丸

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    益气维血胶囊联合多糖铁复合物对妊娠期轻中度缺铁性贫血患者铁代谢的影响

    王晶李玲玲史佳玉刘小敏...
    113-116页
    查看更多>>摘要：目的 研究益气维血胶囊联合多糖铁复合物对妊娠期轻中度缺铁性贫血(IDA)患者铁代谢的影响。 方法 回顾性观察性研究。抽取2018年9月至2023年5月河南中医药大学第一附属医院收治的妊娠期轻中度IDA患者94例，按照治疗方法分为单一组和联合组，每组47例。单一组采用多糖铁复合物治疗，联合组在单一组基础上联用益气维血胶囊。比较两组疗效，比较两组治疗前后血常规指标[血红蛋白(Hb)、红细胞计数(RBC)、平均红细胞体积(MCV)]水平、铁代谢指标[铁蛋白(SF)、血清铁(SI)]水平，比较两组不良妊娠结局发生率及不良反应发生率。 结果 联合组总有效率(95.74%，45/47)高于单一组(78.72%，37/47)，P<0.05。治疗后，联合组Hb、RBC、MCV水平高于单一组(P<0.05)；治疗后，联合组SF、SI水平高于单一组(P<0.05)。联合组不良妊娠结局发生率(4.26%，2/47)与单一组(8.51%，4/47)比较差异未见统计学意义(P>0.05)；联合组不良反应发生率(4.26%，2/47)低于单一组(21.28%，10/47)，P<0.05。 结论 益气维血胶囊联合多糖铁复合物治疗妊娠期轻中度IDA效果显著，能改善患者血常规指标和铁代谢指标，降低不良反应发生率。 Objective To study the effect of Yiqi Weixue capsule combined with polysaccharide iron complex on iron metabolism in patients with mild to moderate iron-deficiency anemia (IDA) during pregnancy. Methods This study was a retrospective observational study. A total of 94 patients with mild to moderate IDA during pregnancy treated in the First Affiliated Hospital of Henan University of Chinese Medicine from September 2018 to May 2023 were selected, and they were divided into single group and combined group according to therapeutic method, with 47 cases in each group. The single group was treated with polysaccharide iron complex, and the combined group was treated with Yiqi Weixue capsule based on the treatment of the single group. The efficacy, levels of blood routine indexes, including hemoglobin (Hb), red blood cell count (RBC) and mean corpuscular volume (MCV), levels of iron metabolism indexes, including serum ferritin (SF) and serum iron (SI), were compared between the two groups before and after treatment. The incidence of adverse pregnancy outcome and incidence of adverse reactions of the two groups were compared. Results The total effective rate of the combined group (95.74%, 45/47) was higher than that of the single group (78.72%, 37/47), P<0.05. After treatment, the combined group had higher levels of Hb, RBC and MCV compared with the single group (P<0.05). After treatment, the combined group had higher levels of SF and SI compared with the single group (P<0.05). There was no significant difference in the incidence of adverse pregnancy outcomes between the combined group (4.26%, 2/47) and the single group (8.51%, 4/47),P>0.05. The incidence of adverse reactions in the combined group (4.26%, 2/47) was lower than that in the single group (21.28%, 10/47),P<0.05. Conclusions The combination of Yiqi Weixue capsule and polysaccharide iron complex has a significant effect in the treatment of mild to moderate IDA, which can improve blood routine and iron metabolism indicators, and reduce incidence of adverse reactions.

    缺铁性贫血妊娠期益气维血胶囊多糖铁复合物铁代谢

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