首页|Bidysoxyphenols A–C, dimeric sesquiterpene phenols from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm

Bidysoxyphenols A–C, dimeric sesquiterpene phenols from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm

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? 2022 Elsevier B.V.Three new sesquiterpene phenol dimers, bidysoxyphenols A–C (2–4), along with two known compounds, namely sesquiterpene phenol (1) and ionone derivatives (5), were isolated from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm. The structures of these new compounds, including their absolute configurations, were elucidated by nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, infrared spectroscopy, high-resolution electrospray ionization time-of-flight mass spectrometry, and electronic circular dichroism. Compounds 1 and 2 showed cytotoxicity against human promyelocytic leukemia cells, with IC50 values of 18.25 ± 1.52 and 39.04 ± 3.12 μM, respectively.

CytotoxicityDysoxylum parasiticumHL60 cellsMeliaceaeSesquiterpene phenol dimers

Sofian F.F.、Shiono Y.、Koseki T.、Subarnas A.、Hakozaki M.、Uesugi S.

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The United Graduate School of Agricultural Sciences Iwate University

Department of Food Life and Environmental Science Faculty of Agriculture Yamagata University

Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy Universitas Padjadjaran

Iwate Biotechnology Research Center

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2022

Fitoterapia

Fitoterapia

SCI
ISSN:0367-326X
年,卷(期):2022.158
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